These 384-well plates enable researchers to use the Echo® liquid handler to enhance the safety and accuracy of the manipulation of venoms.
The Acoustic Venom Discovery Array enables diverse biological samples to be screened in higher throughput with greater accuracy and simplicity with Dynamic Fluid Analysis™ on Echo systems. Dynamic Fluid Analysis, introduced in early 2012 by Labcyte, acts in real time on a well-by-well basis to ensure a wide range of fluid types within a microplate are transferred with precision and accuracy from Echo qualified source plates. By compensating for inherent variations in potent, biological fluids such as venoms, the Echo can handle the dispensing of the Acoustic Venom Discovery Array as it would a compound library or a natural products library in DMSO.
“A variety of venoms have shown great utility in disease areas such as cancer, haematology, antimicrobials, immunology, growth factors and natriuresis,” said Steven Trim, founder of Venomtech. “Scientific literature is rapidly growing around the use of venom components as novel leads and therapeutics for targets such as ion channels, enzymes, GPCRs and many others.”
The Labcyte Echo liquid handler revolutionizes liquid transfer by using acoustic energy to eject fluids. The Echo allows for assay miniaturization to previously unattainable volumes, transferring 2.5 nL droplets repeatedly, so precision and accuracy are consistent over a larger volume range. Large volume transfer is achieved by transferring several hundred droplets per second. Transfer is non-contact and tipless, with increased cost savings from elimination of tip costs and washing fluids.
Miniaturization with the Echo liquid handler retains high assay performance, allowing quantitative results at higher assay well densities. The Echo liquid handler can be used to transfer from any source well position to any destination well position. These can be simple fluids (media for growing cells, buffers, DMSO) or viscous solutions (lysis buffers, antibodies with glycerol, or transfection reagents and now venom).