Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Life Technologies Begins Shipping Ion Proton System

Published: Friday, September 14, 2012
Last Updated: Friday, September 14, 2012
Bookmark and Share
Ion Proton™ System brings genome-scale sequencing to every lab by removing high cost and complexity.

Life Technologies Corporation announced it is now shipping the Ion Proton™ System. The platform's speed, ease-of-use and affordability will democratize genome sequencing. For the first time, genome-scale sequencing is accessible to all scientists and medical researchers, enabling an unprecedented wave of innovation in life sciences and the advancement of clinical research.

"The Ion Proton System is an important milestone in our vision to drive innovation, economic growth and scientific progress by transforming the genome center into a simple desktop sequencer," said Gregory T. Lucier, Chairman and Chief Executive Officer of Life Technologies. "A key area where we will see these future advances is in clinical research, where physician-scientists dealing with previously intractable conditions like cancer will finally have the tools to confidently understand, identify and treat the disease. This is an inflection point in the history of research, and there is much more to come."

Previously, genome-scale sequencing has only been possible at large centers or core labs because it required specialized molecular biology skills, expensive sequencers, extensive IT infrastructure and large numbers of bioinformatics specialists. With the introduction of the Ion Proton™ System, Life Technologies now offers a solution to overcome all of these barriers, enabling scientists to sequence within budget, on schedule and on the bench top in their own labs.

Automated sample prep for all labs
Life Technologies is introducing two new automated template preparation instruments: the Ion OneTouch™ 2 System and Ion Chef™ System. The Ion OneTouch™ 2 System is ideal for labs with a Proton and medium throughput requirements. The Ion Chef™ System is ideal for labs with any level of molecular biology expertise, or for labs with high-throughput requirements. It automates the upfront sequencing workflow, going from library to "loaded chips" with just minutes of hands-on time, and is scheduled to ship in the first half of next year.

Semiconductor technology enables sequencing for all budgets, in all labs
The Ion Proton™ System is one-third the cost of light-based genome-scale sequencing systems, saving researchers hundreds of thousands of dollars. Additionally, at just $1,000 per run, scientists can afford to follow a one-off idea or invest in a major study. Using the Ion PI™ Chip, available today, the system can sequence exomes and transcriptomes in just two to four hours. Initially the system will deliver 60-80 million filtered reads and up to 10 Gb of output, with potential for higher performance. Read-lengths are 100 to 200 bp and the consensus accuracy is comparable to that of the Ion PGM™ sequencer.

Life Technologies plans to ship more than 100 Ion Proton™ Systems to customers in September and continues to take additional orders and experience strong customer demand for the platform.

The Ion PII™ Chip is designed to sequence the human genome in just a few hours for $1,000, and is expected to ship approximately 6 months following today's Ion Proton System launch. The Ion Proton instrument, chemistry and chip architecture are designed to accommodate the higher well density of the Ion PII™. Historically, each time the well diameter of Ion chips is reduced by half, the signal has quadrupled.

The Ion Proton™ System's technology builds on the rapid advances in increasing throughput, accuracy and read-length made by the Ion Personal Genome Machine® (PGM™) Sequencer. The Ion PGM™ became the fastest-selling sequencer in the world in just six months, and by the end of the first half of 2012 more than 1,000 units were in research labs around the world.

"The Ion Proton™ System is the outcome of 40 years of accumulated Moore's law, starting with technologies that enabled the moon landing and that ultimately gave us modern electronics, computing and communications," said Ion Torrent CEO and Founder Jonathan M. Rothberg. "Now, for the first time, we are leveraging the trillion dollars that has gone into semiconductor development to 'see' chemistry and directly decode genomes."

Dr. Rothberg announced today at the Ion World 2012 customer conference that Life Technologies has developed Avalanche™, a revolutionary 30-minute emulsion-free template preparation chemistry that will work on all Ion platforms. Dr. Rothberg also announced that Avalanche™ will enable an Ion PIII™ Chip for the Proton, with more than 1.2 billion sensors that will take researchers beyond the $1,000 genome. Both innovations are possible because of the rapid pace of development afforded by Ion Torrent's invention of semiconductor sequencing technology.

A desktop server IT solution for genome-scale sequencing
Life Technologies has replaced the IT server room with a simple desktop server by moving primary analysis to the sequencer and using the most advanced technology from Intel®, Nvidia® and Altera® to enable the highest direct link between the biological and digital worlds.

"We are pleased that when Ion Torrent wanted the most advanced components to support the highest sequencing data throughput in the world, they turned to Intel technology and our team of engineers to help make the Ion Proton™ a success," said David Brown, Marketing Director, Enterprise Platform and Services Division (EPSD) for Intel. "We have enjoyed our collaboration over the last year to create one of the most advanced sequencing systems in the world."

Automated bioinformatics solution for genome-scale sequencing
Ion Reporter™ Software, Life Technologies' cloud-based bioinformatics solution, performs alignments, identifies variants, and delivers automated annotation on data for paired tumor normal samples, and trio samples for inherited disease, from both the Ion Proton™ and Ion PGM™ platforms.

The system's pre-configured workflows make it easy to use, generate a report that classifies variants into simple categories, and make interpretation easier for researchers just getting started with sequencing. For example, the Ion Reporter™ Ingenuity Variant Analysis™ workflow streamlines exome-scale discovery by providing curated annotations to rapidly get to causal variants.

Driving innovation in clinical research
The rapid performance advancement of the Ion PGM™ Sequencer, including read-length, accuracy and throughput, positions Life Technologies to "lock down" robust kits and protocols to prepare for 510(k) clearance with the U.S. Food and Drug Administration (FDA) and other key regulatory agencies around the world. The Ion Proton™ System, which is built on the foundation underlying Ion PGM™ technology, gives researchers the rapid turnaround, ease-of-use, and affordability to go from multiplex sample sequencing to genome-scale sequencing on a single platform. After a period of deployment in the research market, Life Technologies also plans to develop the Ion Proton™ System for clearance with the FDA.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

KACST Partners with Life Tech in The Saudi Human Genome Program
Program aims to analyze 100,000 human genomes to identify the causes of disease in the population of the Kingdom of Saudi Arabia and the Arab world.
Monday, December 09, 2013
Life Technologies Awards Digital PCR Innovation Grants to Five Research Labs
The five Innovation Grant recipients in the Digital PCR Applications Grant Program was announced during the ASHG conference in Boston.
Thursday, October 24, 2013
Thermo Acquisition Approved by Life Technologies Stockholders
Company announced that its stockholders voted to adopt the previously announced merger agreement.
Thursday, August 22, 2013
Life Technologies Enters into an Exclusive License and Supply Agreement for Dynabead
Life Technologies has signed a long-term supply and exclusive licensing agreement with Novartis for immunotherapeutics involving T cells modified to express chimeric antigen receptors for the treatment of cancer.
Thursday, August 01, 2013
Life Technologies Announces Second Quarter 2013 Results
Revenue increased 1% excluding impact of currency.
Thursday, August 01, 2013
Life Technologies Signs Five-Year Agreement with the FDA
The agreement aims to accelerate and advance food safety testing of E. coli and Salmonella, two foodborne contaminants commonly associated with outbreaks and/or recalls.
Tuesday, July 30, 2013
Roswell Park Cancer Institute Purchases Six Ion Torrent Sequencers
Life Technologies Corporation announced that the new Center for Personalized Medicine at Roswell Park Cancer Institute has purchased four Ion Proton™ sequencers and two Ion Personal Genome Machine™ sequencers.
Thursday, February 21, 2013
Boston Children's Hospital and Life Technologies Launch Claritas Genomics, a Clinical Genomics Company
Spinoff venture will develop genomic sequencing solutions utilizing Ion Torrent technology for clinical applications.
Thursday, January 10, 2013
Life Technologies introduces Ion AmpliSeq™ Community Panels
Ion AmpliSeq™ Community Panels leverages the expertise of scientific thought leaders and the Ion Community to create gene panels for conditions ranging from cancer to inherited diseases.
Wednesday, November 07, 2012
Life Technologies Acquires Compendia Bioscience
Acquisition expands Life Technologies' ability to drive progress in personalized medicine
Sunday, October 14, 2012
Life Technologies Acquires Compendia Bioscience
Bioinformatics expertise will enable deeper engagement with established customer base of leading pharmaceutical companies.
Tuesday, October 09, 2012
Life Technologies Signs Collaborative Agreement with Structural Genomics Consortium
Pioneering joint venture releases 58 of 200 planned, highly-specific recombinant antibodies for epigenetic studies.
Thursday, July 19, 2012
Life Technologies Collaborate with University of North Texas Health Science Center
University of North Texas Health Science Center advances forensic research by investing in semiconductor DNA sequencing technology.
Thursday, June 21, 2012
SickKids Adopts Life Technologies' Ion Proton™ Sequencer to Launch New Centre for Genetic Medicine
Long-term partnership will focus on sequencing 10,000 genomes per year to revolutionize pediatric disease research in Canada.
Thursday, June 21, 2012
Life Technologies Teams with Universitry of North Texas
University Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology.
Thursday, June 21, 2012
Scientific News
Genes That Protect African Children From Developing Malaria Identified
Variations in DNA at a specific location on the genome that protect African children from developing severe malaria, in some cases nearly halving a child’s chance of developing the life-threatening disease, have been identified in the largest genetic association study of malaria to date.
Researchers Disguise Drugs As Platelets to Target Cancer
Researchers have for the first time developed a technique that coats anticancer drugs in membranes made from a patient’s own platelets.
Dormant Viral Genes May Awaken to Cause ALS
NIH human and mouse study may open an unexplored path for finding treatments.
Scientists Create World’s Largest Catalog of Human Genomic Variation
An international team of scientists from the 1000 Genomes Project Consortium has created the world’s largest catalog of genomic differences among humans, providing researchers with powerful clues to help them establish why some people are susceptible to various diseases.
Five Genetic Regions Implicated In Cystic Fibrosis Severity
An international consortium of researchers conducted the largest-ever CF genome-wide analysis to find new therapeutic targets.
Greater Understanding Of Polycystic Ovary Syndrome
A new genetic study of over 200,000 women reveals the underlying mechanisms of polycystic ovary syndrome, as well as potential interventions.
New Autism Genes Are Revealed in Largest-Ever Study
Work draws more detailed picture of genetic risk, sheds light on sex differences in diagnosis.
A Fundamental Protection Mechanism Against Formalin In Mammals is Revealed
Formaldehyde, or formalin, is well known to all of us as a common chemical used in many industrial processes and also as a preservative, remarkably we also produce formaldehyde in our bodies.
A New Single-Molecule Tool to Observe Enzymes at Work
A team of scientists at the University of Washington and the biotechnology company Illumina have created an innovative tool to directly detect the delicate, single-molecule interactions between DNA and enzymatic proteins.
Genetic Adaptations to Diet and Climate
Researchers found genetic variations in the Inuit of Greenland that reflect adaptations to their specific diet and climate.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos