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OGT Releases New CytoSure™ ISCA +SNP Array

Published: Monday, September 24, 2012
Last Updated: Monday, September 24, 2012
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New microarray for accurate detection of copy number changes and loss of heterozygosity using a single array.

Oxford Gene Technology (OGT) has released the latest addition to its range of CytoSure™ ISCA microarrays for reliable and standardized genomic aberration detection.

The new patent pending CytoSure ISCA +SNP (4x180k) array combines array comparative genomic hybridization (aCGH) probes, endorsed by the International Standards for Cytogenomic Arrays (ISCA) Consortium, with fully validated single nucleotide polymorphism (SNP) content.

This allows the accurate and cost-effective detection of copy number changes and loss of heterozygosity (LOH) using a single array.

As the newest member of the CytoSure ISCA array portfolio, the CytoSure™ ISCA +SNP array includes enhanced SNP coverage for high-resolution LOH detection.

This means that the analysis of genetically complex samples from related individuals is now even more accurate and in-depth, while integration with OGT’s powerful and intuitive CytoSure Interpret Software ensures that analysis is easy, fast and insightful.

James Clough, Vice President Clinical and Genomic Solutions at OGT, commented: “For several years, OGT has worked closely with ISCA to design a range of arrays focused on providing standardized, evidence-based content. The latest CytoSure ISCA +SNP design is part of our ongoing commitment to further enhancing the accuracy, reproducibility and efficiency of genomic analysis using microarrays, by creating powerful, multi-feature arrays that generate as much relevant data as possible.”

Although aCGH is the gold standard for detecting copy number variation (CNV), until recently it was not possible to combine this technique with LOH and uniparental disomy (UPD) detection using SNP probes.

This meant that either two separate arrays were needed, or that inferior SNP-based CNV detection platforms were used. To solve this problem, the CytoSure ISCA +SNP array allows CNV and SNP detection to be carried out on a single array, using optimized probes that are fit for each purpose.

By allowing both methods to work efficiently under standard CytoSure aCGH hybridization conditions, these arrays fit seamlessly into existing workflows.

To provide as much relevant information as possible, the arrays include content specifically designed to focus on disease and syndrome-associated regions, in addition to offering whole genome ‘backbone’ coverage.

To simplify the analysis of samples such as those suspected of exhibiting UPD, OGT provides all users of CytoSure arrays with its industry-leading CytoSure Interpret Software.

With various innovative features, the software maximizes the ease, consistency and speed of data interpretation, while minimizing the need for user intervention.

The results provided include extensive annotation tracks covering syndromes, genes, exons, CNVs and recombination hotspots, while links to publicly available databases put results into context.

Using the comprehensive range of CytoSure products, the transition from sample to biological insight is always fast, accurate and reliable.

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