Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Horizon Launches SyntheTx Partnership Program

Published: Friday, October 05, 2012
Last Updated: Friday, October 05, 2012
Bookmark and Share
H3 Biomedicine is first partner for program aimed at generating ‘first-in-class’ patient-relevant targets based on synthetic lethality screens.

Horizon Discovery Ltd (Horizon) and H3 Biomedicine Inc. have announced the launch of SyntheTx, a technology partnership program aiming to become a major supplier of novel oncology targets and early-stage drug discovery programs to the pharmaceutical industry.

H3 Biomedicine, a biopharmaceutical company specializing in the discovery and development of targeted patient-specific cancer treatments, is the first partner for the program.

Additional biotechnology and/or pharmaceutical partners will be sought in the first 12 to 18 months of the program.

Professor Alan Ashworth, Professor of Molecular Biology at the Institute of Cancer research (ICR) and pioneer of synthetic lethality screening, will join Horizon’s Scientific Advisory Board to provide oversight of the program.

Horizon and H3 Biomedicine will screen up to 50 currently “undruggable” but key cancer-driving genotypes, with the aim of identifying a range of targets that will be optioned by Horizon and H3 for further development.

Any targets not optioned by H3 Biomedicine or Horizon will be made available on commercial terms to the pharmaceutical industry at the end of the program.

The program will also capitalize on Horizon’s precision genome editing technology (GENESIS™) to perform rigorous target validation and to promote its partners’ capabilities around early lead molecule generation.

Synthetic lethality occurs where the combination of mutations in two or more genes leads to cell death, but a mutation in just one of those genes does not.

In a synthetic lethal genetic screen, it is necessary to begin with a known mutation that does not cause cell death, then systematically test other mutations to determine which combination confers lethality.

Synthetic lethal screens have demonstrated potential in oncology, as these pairs of mutations could be used to selectively kill cancer cells, but leave normal cells relatively unharmed.

Targets selected by the SyntheTx program will have been shown to exhibit synthetic lethality with or co-dependency on a specific genotype.

“Proof-of-concept synthetic lethal screens have shown significant promise in uncovering novel targets, but these studies have so far been unwieldy, difficult to understand and cannot represent all genes of interest,” said Dr. Chris Torrance, Chief Scientific Officer, Horizon.

Dr. Torrance continued, “Isogenic disease models created using our GENESIS gene editing technology will for the first time allow large scale, timely and systematic synthetic lethality screens, incorporating any patient-relevant genetic context.”

SyntheTx brings together Horizon’s ability to generate human isogenic cell lines that accurately replicate specific genetic defects present within defined cancer patient populations, with the high-throughput RNAi and bioinformatics technology platforms of Horizon and H3 Biomedicine.

Utilizing Horizon’s ability to reproduce tumor microenvironment conditions to reveal the genetic dependencies of cancer cells in vitro, SyntheTx aims to uncover points of vulnerability in the genomes of the cancer cell lines screened, and then confirm these vulnerabilities in wider cell panels.

This program of ‘de-orphaning’ the cancer genome is designed to provide a vast number of new druggable synthetic lethal targets with clear patient stratification strategies for future progression by the partners.

Professor Alan Ashworth commented: “My research has been dedicated to investigating the causes, and methods of prevention, diagnosis and treatment of cancer. By discovering new synthetic lethal targets with SyntheTx, significant advances in the treatment of cancer will be possible.”

Dr. Markus Warmuth, Chief Executive Officer, H3 Biomedicine, said: “A key goal of H3 Biomedicine is to bring to the clinic lead molecules based upon highly validated and novel drug targets. Innovative and open collaboration concepts are an important part of our mission - to deliver effective cancer medicines to patients in need. SyntheTx will be an exciting way to capitalize on the new insights provided by cancer genome sequencing efforts.”

SyntheTx’ business model will seek commercialization at three defined stages: early partnering of putative targets in conjunction with rigorous biological validation services; partnering of validated targets; and partnering of small molecule lead discovery programs with either in vitro or in vivo proof-of-concept.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Horizon Launches New E-commerce Platform and Expands UK Headquarters
Key investment includes an integrated web-shop and Enterprise Resource Planning system to support further scale and revenue growth.
Thursday, October 29, 2015
Horizon, Swift Partner on Genomic Reference Standards
Standards to be used to support validation, consistency and accuracy of the panel.
Wednesday, October 28, 2015
Horizon In-licenses Oncology Programme from Servier
License programme with milestone payments of up to £50 million plus royalties on product sales.
Thursday, October 08, 2015
Horizon Enters Bioproduction Cell Line Licensing Agreement with LakePharma, Inc.
LakePharma to take a full commercial license for GS null CHO K1 cell line from Horizon for improved efficiency in biopharmaceutical manufacturing.
Wednesday, September 16, 2015
Horizon and Redx Sign Cancer Research Collaboration
Collaboration to progress Redx Pharma plc’s novel pan-RAF inhibitor program towards out-licensing.
Friday, September 04, 2015
Horizon Discovery Appoints Mr Grahame Cook as a Non-Executive Director
Grahame brings over 20 years’ experience to Horizon.
Thursday, May 14, 2015
Transgenomic to Incorporate Horizon's Genomic Reference Standards
Horizon to provide human genomic reference standards to assure quality and performance of Transgenomic’s Multiplexed ICE COLD-PCR kits.
Thursday, April 23, 2015
Horizon Discovery & Thermo Agreement
Horizon Discovery Group plc and Thermo Fisher Scientific sign supply and commercialization agreement, which will see Thermo market and distribute Horizon’s X-MAN cell line collection.
Monday, April 20, 2015
Horizon and Partners Awarded Up to £6.2M Funding
Horizon to receive up to £652,000 to expand bioproduction research.
Thursday, March 26, 2015
Horizon Discovery Group plc and ArcherDX Sign OEM Agreement
Horizon’s Reference Materials chosen by ArcherDX to validate its FusionPlex test for non-small cell lung cancer markers.
Tuesday, March 24, 2015
Horizon Discovery Group plc Named Business of the Year at Business Weekly Awards
Horizon joins select group of companies to receive award for a second time.
Wednesday, March 18, 2015
Horizon to Support Cancer Research UK’s Stratified Medicine Program
Horizon’s Diagnostics division to provide genetically defined, human genomic reference standards.
Friday, March 13, 2015
Horizon Discovery Group to Support Cancer Research UK’s Stratified Medicine Program
Horizon’s Diagnostics division to provide genetically defined, human genomic reference standards.
Wednesday, March 11, 2015
Horizon Discovery CEO Darrin Disley wins Entrepreneur of the Year
Darrin Disley, CEO of Horizon Discovery, wins Entrepreneur of the Year award at the Quoted Company Awards 2015.
Thursday, January 29, 2015
Horizon Discovery Group plc Trading Update
Revenues expected to be ahead of consensus by approximately 7% driven by an increased global demand for expanded product, service and IP offering.
Monday, January 19, 2015
Scientific News
Light Signals from Living Cells
Fluorescent protein markers delivered under high pressure.
Counting Cancer-busting Oxygen Molecules
Researchers from the Centre for Nanoscale BioPhotonics (CNBP), an Australian Research Centre of Excellence, have shown that nanoparticles used in combination with X-rays, are a viable method for killing cancer cells deep within the living body.
Genomic Signature Shared by Five Types of Cancer
National Institutes of Health researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
Switch Lets Salmonella Fight, Evade Immune System
Researchers at the University of Illinois at Chicago have discovered a molecular regulator that allows salmonella bacteria to switch from actively causing disease to lurking in a chronic but asymptomatic state called a biofilm.
Genetic Cause of Rare Allergy
Institute has identified a genetic mutation responsible for a rare form of inherited hives induced by vibratory urticaria.
Mitochondria Shown to Trigger Cell Ageing
An international team of scientists has for the first time shown that mitochondria, the batteries of the cells, are essential for ageing.
Cancer Cells Kill Off Healthy Neighbours
Cancer cells create space to grow by killing off surrounding healthy cells, according to UK researchers working with fruit flies.
Validating the Accuracy of CRISPR-Cas9
IBS Researchers create multiplex Digenome-seq to find errors in CRISPR-Cas9 processes.
Cancer Drug Target Visualized at Atomic Resolution
New study using cryo-electron microscopy shows how potential drugs could inhibit cancer.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!