Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Study Identifies Novel Chemicals Targeting Cancer Stem Cells

Published: Wednesday, November 28, 2012
Last Updated: Wednesday, November 28, 2012
Bookmark and Share
Verastem, Inc., announced that researchers have published a study utilizing the cancer stem cell screening assay exclusively licensed to Verastem to identify novel chemicals that preferentially kill cancer stem cells.

Published in the Journal of Biomolecular Screening, researchers at the Broad Institute of Harvard University and the Massachusetts Institute of Technology utilized the screen originally developed in the laboratories of Verastem scientific cofounders Robert Weinberg, Ph.D. and Eric Lander, Ph.D. Due to the difficulty in propagating cancer stem cells outside of the tumor environment, the researchers created unique cancer stem cell-like cells and used phenotypic high-throughput screening to evaluate 300,718 compounds for their ability to preferentially kill cancer stem cells. The screen identified 2,244 hits and further characterized selective compounds.

“This study demonstrates the power of the cancer stem cell screening technology that was developed by our founders and underpins our research at Verastem,” said Jonathan Pachter, Ph.D., Verastem Vice President and Head of Research. “To date, innovation in cancer therapy has been limited by a myopic focus only on targeting bulk tumor cells with little regard for resistant cancer stem cell populations. Verastem is harnessing the power of cancer stem cell-directed screens to identify novel drugs that have the ability to kill the cellular components of the tumor that resist current therapies and drive tumor recurrence.”

The top three chemical series described in the current study are exclusively licensed to Verastem and are part of a portfolio of drugs being advanced for the treatment of a broad range of cancer indications.
Verastem has built a pipeline of novel chemical series that have demonstrated the unique ability to kill cancer stem cells and plans to enter into multiple clinical studies, including a potential registration study in mesothelioma, over the next 12 months.

The article is titled “Phenotypic High-Throughput Screening Elucidates Target Pathway in Breast Cancer Stem-Like Cells.” View the complete text of the study at http://bit.ly/WfDzSB


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Verastem Discloses Research Results and Updated Clinical Plans
Company hosted its annual Research and Development Day where Robert Weinberg, Ph.D., Verastem co-founder and chair of the Scientific Advisory Board, gave a seminar on cancer stem cells.
Thursday, July 12, 2012
Scientific News
RNAi Screening Trends
Understand current trends and learn which application areas are expected to gain in popularity over the next few years.
New Weapon in the Fight Against Blood Cancer
This strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
Toxin from Salmonid Fish has Potential to Treat Cancer
Researchers from the University of Freiburg decode molecular mechanism of fish pathogen.
Study Finds Non-Genetic Cancer Mechanism
Cancer can be caused solely by protein imbalances within cells, a study of ovarian cancer has found.
Scientists Create CRISPR/Cas9 Knock-In Mutations in Human T Cells
In a project spearheaded by investigators at UC San Francisco, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9.
Tracking Breast Cancer Before it Grows
A team of scientists led by University of Saskatchewan researcher Saroj Kumar is using cutting-edge Canadian Light Source techniques to screen and treat breast cancer at its earliest changes.
DNA Damage Seen in Patients Undergoing CT Scanning
Along with the burgeoning use of advanced medical imaging tests over the past decade have come rising public health concerns about possible links between low-dose radiation and cancer.
The Mystery of the Instant Noodle Chromosomes
Researchers from the Lomonosov Moscow State University evaluated the benefits of placing the DNA on the principle of spaghetti.
Oxitec ‘Self-Limiting Gene’ Offers Hope for Controlling Invasive Moth
A new pesticide-free and environmentally-friendly way to control insect pests has moved ahead with the publication of results showing that Oxitec diamondback moths (DBM) with a ‘self-limiting gene’ can dramatically reduce populations of DBM.
Web App Helps Researchers Explore Cancer Genetics
Brown University computer scientists have developed a new interactive tool to help researchers and clinicians explore the genetic underpinnings of cancer.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!