Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Do-it-Yourself Viruses: How Viruses Self Assemble

Published: Tuesday, December 18, 2012
Last Updated: Monday, December 17, 2012
Bookmark and Share
New model shows that the construction of intermediate structures prior to final capsid production can be more efficient than constructing the capsid protein by protein.

A new model of the how the protein coat (capsid) of viruses assembles, published in BioMed Central's open access journal BMC Biophysics, shows that the construction of intermediate structures prior to final capsid production (hierarchical assembly) can be more efficient than constructing the capsid protein by protein (direct assembly).

The capsid enveloping a virus is essential for protection and propagation of the viral genome. Many viruses have evolved a self-assembly method which is so successful that the viral capsid can self assemble even when removed from its host cell.

The construction of large protein structures has been observed experimentally but the mechanism behind this is not well understood.

Even the 'simple' icosahedral protein coat of the T1 virus requires integration of 60 protein components. Computational models of the physical interactions of component proteins are used to investigate the dynamics and physical constraints that regulate whether the components assemble correctly.

Using computer simulations a team from the Institute for Theoretical Physics and the Center for Quantitative Biology (BioQuant), University of Heidelberg, has compared direct and hierarchical assembly methods for T1 and T3 viruses.

The team led by Ulrich S Schwarz, realized that direct assembly often led to the formation of unfavorable intermediates, especially when the dissociation rate was low, which hindered further assembly, causing the process to stall.

In contrast, for many conditions hierarchical assembly was more reliable, especially if the bonds involved had a low dissociation rate.

Discussing the practical applications of these results, Dr Schwarz commented, "Hierarchical assembly has not been systematically investigated before. Theoretical models and computer simulations, like ours, can be used to understand the mechanism behind assembly of complex viruses and give an indication of how other large protein complexes assemble."

He continued, "With our computer simulations, we are now in a position to investigate systems which are too large to be studied by molecular resolution. This rational approach might have many applications not only in biomedicine, but also in materials science, where many researchers strive to learn from nature how to assembly complex structures."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Imaging Software Could Speed Up Breast Cancer Diagnosis
Researchers use high speed optical microscopy of intact breast tissue specimens to analyze breast tissue.
Friday, August 21, 2015
Showing Your Age: Your DNA Doesn't Lie
Using thousands of tissue samples from open access datasets, a scientist has created a calculator which predicts the age of tissue using chemical changes to DNA.
Monday, October 21, 2013
Leukaemia Drug Could Help Treat Breast Cancer
A drug currently used to treat leukaemia might also help prevent breast cancer from spreading to other parts of the body.
Friday, August 23, 2013
No Place to Hide: Evolutionary Forensics
The rapid molecular evolution of hepatitis C virus (HCV) has been used to help incriminate the source of an outbreak in two Spanish hospitals in the late nineties.
Monday, July 29, 2013
Gene Signature Can Predict Who Will Survive Chemotherapy
An eight gene ‘signature’ can predict length of relapse-free survival after chemotherapy, finds new research in Biomed Central’s open access journal BMC Medicine.
Tuesday, April 16, 2013
Oxygen-Free Energy Designed to Fuel Brain Development Spurs on Growth of Cancer
The metabolic process which fuels the growth of many cancers has its origins in normal brain growth finds a new study published in BioMed Central's open access journal Cancer & Metabolism.
Wednesday, January 23, 2013
What Did Our Ancestors Look Like?
A new method of establishing hair and eye colour from modern forensic samples can also be used to identify details from ancient human remains.
Monday, January 14, 2013
Microevolutionary Analysis of C. difficile Genomes to Investigate Transmission
Recent study took a genomics approach to assess the incidence of patient-to-patient transmission of C. difficile.
Thursday, January 03, 2013
Newborn Baby Screening for Fragile X Syndrome
Study for FXS demonstrates testing for mutations in the gene FMR1.
Thursday, January 03, 2013
Transposable Elements Reveal a Stem Cell Specific Class of Long Noncoding RNAs
Over a decade after sequencing the human genome, it has now become clear that the genome is not mostly 'junk' as previously thought.
Tuesday, November 27, 2012
Open Data Partnership Leads to Release of Data from Nobel Prize-Winning Laboratory for Public Use
Over the last decade an ENU mutagenesis program was operated by the Beutler laboratory at The Scripps Research Institute in La Jolla, CA.
Wednesday, October 24, 2012
How Gene Profiling in Emphysema is Helping to Find a Cure
New research has identified genes whose activity is altered with increasing lung damage and finds that the compound GHK affects the activity of these genes.
Wednesday, September 12, 2012
Understanding the human genome: ENCODE at BioMed Central
The completion of the human genome project in 2003 was an immeasurably important milestone, but (like any book written in code) left many biologists wondering what the sequence might actually mean.
Thursday, September 06, 2012
Genetic Predictor of Breast Cancer Response to Chemotherapy
Gene expression 'signatures' to measure the susceptibility of tumor cells to chemotherapy.
Friday, May 11, 2012
Cellular 'Glue' Resists Breast Cancer
New research demonstrates that the protein Perp provides a potential new target for future treatment of breast cancer.
Thursday, April 19, 2012
Scientific News
A Diversity of Genomes
New DNA from understudied groups reveals modern genetic variation, ancient population shifts.
Gene Could Reduce Female Mosquitoes
Virginia Tech researchers have found a gene that can reduce female mosquitoes over many generations.
Improving Crop Efficiency with CRISPR
New study of CRISPR-Cas9 technology from Virginia Tech shows potential to improve crop efficiency.
Examining mtDNA May Help Identify Unknown Ancestry That Influences Breast Cancer Risk
Researchers studying mtDNA in a group of triple negative breast cancer patients found that 13 percent of participants were unaware of ancestry that could influence their risk of cancer.
Bacteria Use Ranking Strategy to Fight Off Viruses
Researchers have explained why microbes store virus confrontation information sequentially, with most recent attacks first.
Gene Therapy Technique May Help Prevent Cancer Metastasis
Gene-regulating RNA molecules could help treat early-stage breast cancer tumors before they spread.
Enhancing Antibiotics to Defeat Resistant Bacteria
Scientists enhance ability of antibiotics to defeat resistant types of bacteria using molecules called PPMOs
The Genetics of Blood Pressure
Researchers have identifed areas of the genome associated with blood-pressure including 17 previously unknown loci.
Mosquito Genetics Determine Tastes
Study reveals mosuito's preference for human versus animal biting is determined by genetics.
Quadruple Helix DNA Aids Cancer Therapies
Researchers have identified the role that a four-stranded version of DNA may play in the role of cancer progression.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!