Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Gene Responsible for Increased Severity of Influenza in Chinese Populations

Published: Wednesday, January 30, 2013
Last Updated: Wednesday, January 30, 2013
Bookmark and Share
Researchers have found a genetic variant which explains why Chinese populations may be more vulnerable to the H1N1 form of flu, commonly known as swine flu.

This finding could help identify those at high risk of severe infection and help prioritise those in highest need of treatment. Results are published today in Nature Communications.

The study, led by Dr Tao Dong, showed that having this variant in your genetic make-up could increase your chances of severe infection by six times. The variation rs12252-C is occasionally found in Caucasian populations (in around 1 in 3,000 people) and was already known to be associated with more severe influenza. The teams in the UK and China focussed on this variation as it is 100 times more common in Han Chinese, the predominant ethnic group in China. The results showed that it was present in 69 per cent of Chinese patients with severe pandemic (swine) influenza in 2009 compared with 25 per cent who only had a mild version of the infection.

Lead author, Dr Tao Dong at the MRC Human Immunology Unit, Oxford University, says:

“Understanding why some people may be worse affected than others is crucial in improving our ability to manage flu epidemics and to prevent people dying from the virus. Previous studies had shown genetic variant was associated with severe influenza infection in Europeans, but this variant is extremely rare in Europeans. We became interested in this because we noticed it is 100 times more common in China. It’s vital that we continue to fund research that examines flu infection, from the smallest details of our genetic code and in the populations around the world that continue to be vulnerable to infection.”

Co-author, Professor Andrew McMichael at the MRC Human Immunology Unit, Oxford University, adds:

“The apparent effect of this gene variant on the severity of influenza is of great interest. It remains to be seen how this gene affects the whole picture of influenza in China and South East Asia but it might help explain why new influenza viruses often first appear in this region of the world.”

The original work on the genetic variation rs12252-C and flu severity was carried out by Professor Paul Kellam at the Wellcome Trust Sanger Centre in Cambridge and Professor Peter Openshaw at Imperial College London. The work was supported by the Medical Research Council, Wellcome Trust Sanger Institute, the Beijing Natural Science Foundation, Beijing Municipal Science and Technology Commission, National S&T Major Project for Infectious Diseases Control, Beijing Youan Hepatitis/AIDS Foundation and the National Natural Science Foundation of China.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Redirecting the Rules of Attraction in Fruit Flies
MRC researchers have discovered a biological switch that determines which part of the fruit fly’s brain responds to pheromones, depending on whether the fruit fly is male or female.
Friday, December 20, 2013
A Gene Mutation for Excessive Alcohol Drinking Found
UK researchers have discovered a gene that regulates alcohol consumption and when faulty can cause excessive drinking.
Wednesday, November 27, 2013
£93 Million Package of Support Announced for UK’s Health Industries
Innovative business and academic projects will benefit from a new £93.2 million package of support.
Wednesday, July 31, 2013
New £23m Research Unit will use Advances in Genetics to Help Reduce Risk of Disease
Unit will exploit the latest advances in genetics to improve understanding of how changes to lifestyle or environment can reduce the risk of disease.
Monday, May 20, 2013
World’s Largest Respiratory Genetics Study Launches on World COPD Day
Researchers funded by the Medical Research Council (MRC) are to conduct the largest ever study of the genetics relating to lung disease.
Thursday, November 15, 2012
A Phenomenal Legacy for London 2012
The Phenome Centre will use the cutting edge facilities developed for London 2012 to help develop better and more targeted treatment for patients.
Wednesday, August 01, 2012
MRC Cash Boost to Maximize Discovery of Mouse Models of Human Diseases
Medical Research Council to invest £61m over the next five years into mouse genetics research at MRC Harwell, Oxfordshire.
Monday, March 21, 2011
Polio Research Gives new Insight into Tackling Vaccine-Derived Poliovirus
Newly published research findings highlight the importance of completing polio eradication.
Friday, June 25, 2010
Scientists uncover new hereditary links to Alzheimer’s disease
Two genes which increase a person’s likelihood of developing the most common form of Alzheimer’s disease have been discovered in the largest-ever study of its kind into the illness.
Monday, October 05, 2009
Location of genetic varation is key to potential role in disease
Genetic variation is widely recognised as the key to survival and continued evolution of a species.
Friday, August 22, 2008
Scientific News
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Searching Big Data Faster
Theoretical analysis could expand applications of accelerated searching in biology, other fields.
Growing Hepatitis C in the Lab
Recent discovery allows study of naturally occurring forms of hepatitis C virus (HCV) in the lab.
Inciting an Immune Attack on Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Reprogramming Cancer Cells
Researchers on Mayo Clinic’s Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy.
Genetic Overlapping in Multiple Autoimmune Diseases May Suggest Common Therapies
CHOP genomics expert leads analysis of genetic architecture, with eye on repurposing existing drugs.
Surprising Mechanism Behind Antibiotic-Resistant Bacteria Uncovered
Now, scientists at TSRI have discovered that the important human pathogen Staphylococcus aureus, develops resistance to this drug by “switching on” a previously uncharacterized set of genes.
How DNA ‘Proofreader’ Proteins Pick and Edit Their Reading Material
Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have discovered how two important proofreader proteins know where to look for errors during DNA replication and how they work together to signal the body’s repair mechanism.
Fat in the Family?
Study could lead to therapeutics that boost metabolism.
Tissue Bank Pays Dividends for Brain Cancer Research
Checking what’s in the bank – the Brisbane Breast Bank, that is – has paid dividends for UQ cancer researchers.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!