Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Study Maps Human Metabolism in Health and Disease

Published: Tuesday, March 05, 2013
Last Updated: Tuesday, March 05, 2013
Bookmark and Share
Scientists have produced an instruction manual for the human genome that provides a framework to better understand the relationship between an individual's genetic make-up and their lifestyle.

The international team of researchers say their study - published in Nature Biotechnology - provides the best model yet to explain why individuals react differently to environmental factors such as diet or medication.

"This research is the second, important stage of our understanding of the human genome," said study author Professor Pedro Mendes, from The University of Manchester's School of Computer Science. "If the sequencing of the human genome provided us with a list of the biological parts then our study explains how these parts operate within different individuals.

"The results provide a framework that will lead to a better understanding of how an individual's lifestyle, such as diet, or a particular drug they may require is likely to affect them according to their specific genetic characteristics. The model takes us an important step closer to what is termed 'personalised medicine', where treatments are tailored according to the patient's genetic information."

The research, which involved scientists from Manchester, Cambridge, Edinburgh, Reykjavik, San Diego, Berlin, the BBSRC-funded Babraham Institute and many others, mapped 65 different human cell types and half of the 2,600 enzymes that are known drug targets in order to produce the network model.

Co-author Douglas Kell, Chief Executive of Biotechnology and Biological Sciences Research Council (BBSRC) and Professor of Bioanalytical Science at the Manchester Institute of Biotechnology, said: "To understand the behaviour of a system one must have a model of it. By converting our biological knowledge into a mathematical model format, this work provides a freely accessible tool that will offer an in-depth understanding of human metabolism and its key role in many major human diseases.

"This study offers the most complete model of the human metabolic network available to date to help analyse and test predictions about the physiological and biochemical properties of human cells."

Dr Nicolas Le Novère, from the Babraham Institute said: "This is a model that links the smallest molecular scale to the full cellular level. It contains more than 8,000 molecular species and 7,000 chemical reactions - no single researcher could have built this alone. Having large collaborations like these, using open standards and data-sharing resources, is crucial for systems biology."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Genome-Editing Position Statement
A group of leading UK research organisations has today issued an initial joint statement in support of the continued use of CRISPR-Cas9 and other genome-editing techniques in preclinical research.
Monday, September 07, 2015
Expanding the DNA Alphabet: 'Extra' DNA Base Found to be Stable in Mammals
A rare DNA base, previously thought to be a temporary modification, has been shown to be stable in mammalian DNA, suggesting that it plays a key role in cellular function.
Thursday, June 25, 2015
Researchers Use ‘Big Data’ Approach to Map the Relationships Between Human and Animal Diseases
EID2 database used to prevent and tackle disease outbreaks around the globe.
Thursday, July 17, 2014
TGAC at the Forefront of Next Generation Sequencing Capability
The Genome Analysis Centre adds two Illumina HiSeq 2500 machines to its platform suite.
Thursday, June 26, 2014
£12M for Synthetic Biology Facilities and Training
The UK Research Councils, led by the BBSRC, will award £10M to establish five centres for DNA synthesis across the UK to further develop the UK's research base in synthetic biology.
Monday, April 07, 2014
Scientists identify ‘long distance scanner’ for DNA damage
BBSRC-funded scientists at the University of Bristol have discovered that a mechanism for preventing mutation within important genes involves long distance scanning of DNA by a molecular motor protein.
Wednesday, February 26, 2014
UK Establishes Three New Synthetic Biology Research Centres
Bristol, Nottingham and a Cambridge/Norwich partnership will be UK centres for synthetic biology.
Friday, January 31, 2014
New Chromosome Map Points the Way Through Campylobacter’s Genetic Controls
The Institute of Food Research has produced a new map of the Campylobacter genome, showing the points where all of this pathogenic bacteria's genes are turned on.
Wednesday, November 13, 2013
BBSRC Invests £10 M in Synthetic Biology
The investment has been allocated to the fund by the BBSRC in response to the 2012 Synthetic Biology Roadmap, which sets out plans to harness opportunities in this area.
Thursday, November 07, 2013
A Community Based Approach for Tackling the Post-Genomic Data Deluge
Correspondence highlights the benefits of a community approach to gathering data that can help improve our understanding of the functions of genes.
Monday, October 14, 2013
‘X-Shape’ Not True Picture of Chromosome Structure, New Imaging Technique Reveals
First 3D pictures of chromosome structure revealed.
Friday, September 27, 2013
Moving Genes have Scientists Seeing Spots
An international team of scientists has perfected a way of watching genes move within a living plant cell.
Wednesday, September 11, 2013
Advance in Understanding Genome Reproduction
Researchers have provided new insight into how chromosome integrity is threatened each time a cell grows and divides, helping to underpin our knowledge of healthy aging.
Thursday, August 01, 2013
£60,000 Competition to Recognise Innovative Scientists Launched by BBSRC
Innovator of the Year 2014 competition launched by BBSRC to recognise and reward scientist's whose excellent science and innovations are delivering real world impact.
Friday, July 12, 2013
Babraham Scientists Establish Cancer-Focussed Collaboration with AstraZeneca
Partnership aims to advance cancer research and develop and evaluate new therapeutic strategies to tackle prostate and pancreatic cancers.
Wednesday, July 10, 2013
Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Discovered Through ‘Big Data’ Analysis
Researchers at the SBP have identified over 100 new genetic regions that affect the immune response to cancer.
New Therapeutic Targets For Small Cell Lung Cancer Identified
Researchers at UTSW Medical Center have identified a protein termed ASCL1 that is essential to the development of small cell lung cancer and that, when deleted in the lungs of mice, prevents the cancer from forming.
Deciphering Inactive X Chromosomes
Untangling the Barr body of inactive X chromosomes valuable for understanding chromosome structure and gene expression.
Micro Disease-Detecting Senor Created
Researchers at McMaster University have created a microscopic disease-detecting sensor that can turn on to detect trace amounts of substances.
Liquid Biopsies Treating Ovarian Cancer
Researchers have discovered a promising monitor and treat recurrence of ovarian cancer. Detecting cancer long before tumours reappear.
Uncovering a New Principle in Chemotherapy Resistance in Breast Cancer
The NIH study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1 or BRCA2 genes.
Understanding Treatment Resistant Melanoma
Researchers have determined how advanced melanoma becomes resistant; a development toward developing treatments.
Investigating ‘Black Box’ of Human Genetics
Investigations into inactive X chromosomes have shown unusual DNA repeat elements are essential for maintaining 3D structure.
Liquid Biopsies: DNA Size Matters
Study finds circulating tumour DNA can be distinguished from healthy DNA through fragment size identification.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!