Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Gene Associated with Almost Doubled Alzheimer’s Risk in African-Americans

Published: Wednesday, April 10, 2013
Last Updated: Wednesday, April 10, 2013
Bookmark and Share
ABCA7, a minor gene variant in whites, is major player in African-Americans.

African-Americans with a variant of the ABCA7 gene have almost double the risk of developing late-onset Alzheimer’s disease compared with African-Americans who lack the variant. The largest genome-wide search for Alzheimer’s genes in the African-American community, the study was undertaken by the Alzheimer’s Disease Genetics Consortium and led by neurologists from Columbia University Medical Center. It will be published in the April 10 issue of the Journal of the American Medical Association. The study was primarily funded by the National Institutes of Health (NIH).

“Our findings strongly suggest that ABCA7 is a definitive genetic risk factor for Alzheimer’s disease among African-Americans,” said study senior author, Richard Mayeux, MD, MS, professor and chair of Neurology at CUMC. “Until now, data on the genetics of Alzheimer’s in this patient population have been extremely limited.”

The ABCA7 gene is involved in the production of cholesterol and lipids, which suggests that lipid metabolism may be a more important pathway in Alzheimer’s disease in African-Americans than in whites. Because cholesterol and lipid imbalances (which eventually lead to vascular disease and heart attacks and strokes) are more common in African-Americans, treatments that reduce cholesterol and vascular disease may potentially be an effective way to reduce or delay Alzheimer’s in this population.

“While we need to conduct research to determine whether reducing cholesterol will lower the chance of Alzheimer’s in African-Americans, maintaining healthy cholesterol levels always has the benefit of lowering one’s risk of heart attack and stroke,” said Dr. Mayeux.

The study involved nearly 6,000 African-American participants, most of whom are volunteers from 18 NIH-funded Alzheimer’s Disease Centers. The Centers and other researchers contributed samples to the Alzheimer’s Disease Genetics Consortium, an NIH-supported research program led by Gerard D. Schellenberg, PhD, at the University of Pennsylvania. Approximately 2,000 of the volunteers were diagnosed with probable Alzheimer’s disease and 4,000 were cognitively normal. The purpose of the study was to look for genetic variants among African-Americans, who are known to have a higher incidence of late-onset Alzheimer’s than whites living in the same community. Ninety percent of all cases of Alzheimer’s, which affect an estimated 5 million Americans aged 65 and older, are described as having the late-onset form of the disease.

“ABCA7 is the first major gene implicated in late-onset Alzheimer’s among African Americans, and it has an effect on disease risk comparable to that of APOE-e4—which has been known for two decades to be a major genetic risk factor in whites,” said Christiane Reitz, MD, PhD, assistant professor of neurology, who conducted the study’s genetic analyses as first author on the paper. “Both genes raise the risk of Alzheimer’s in this population twofold.” The extent of the role of APOE-e4 in African-Americans had been uncertain because of inconsistent results from previous, smaller studies.

“Based on these results, we now know that both APOE-e4 and ABCA7 are major genetic risk factors for African-Americans, whereas for whites, only one of the two—APOE-e4—confers a similar degree of risk,” said Dr. Mayeux, who is also co-director of the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain and the Gertrude H. Sergievsky Center at CUMC. He is the Gertrude H. Sergievsky Professor of Neurology, Psychiatry and Epidemiology.

Several other genes that had recently been linked to Alzheimer’s in white populations were also confirmed in the current study to play a role in African-Americans. “Because they cross ethnic groups, the likelihood increases that these genes are very important in the development of Alzheimer’s,” said Dr. Reitz, who is a member of both the Sergievsky Center and the Taub Institute. “And that gives us clues in our search for the cellular pathways associated with the disease.”

“These findings suggest that the genetic underpinnings of Alzheimer’s disease may vary among different populations—and so should not be treated homogeneously,” said Dr. Reitz.

“One of the key research goals set forth in the National Alzheimer’s Project Act of 2011 is to improve outcomes for ethnic and racial minority populations that are at higher risk for this devastating disease,” said Neil Buckholtz, PhD, of the National Institute on Aging, which leads the NIH effort to find ways to treat, delay or prevent Alzheimer’s. “These findings advance our understanding of genetic underpinnings that may play a role in disease onset and progression in African-Americans and suggest a novel target for therapeutic development.”

ABCA7 also affects the transport of several important proteins, including amyloid precursor protein, which is involved in the production of amyloid—the major source of the plaques that develop in the brains of Alzheimer’s patients. Thus, there are multiple ways that ABCA7 might contribute to an increased risk of late-onset Alzheimer’s disease among African-Americans.

The most immediate impact of the new findings will be for scientists studying the causes of Alzheimer’s and ways to prevent the disease. “Our next step is to do more lab work and more genetic sequencing, to understand the biological reasons for the increased risk seen with ABCA7 and other genes implicated in late-onset Alzheimer’s disease,” said Dr. Mayeux.

While the study’s discoveries may eventually lead to the development of genetic risk estimates specific to African-Americans, Dr. Mayeux cautions that the utility of genetic testing for Alzheimer’s is still years away. “We are not yet at the point where we can take what we know about Alzheimer’s genes and come up with an accurate risk assessment,” he said.

The study’s findings also must be replicated in independent groups of African-Americans.

“The participant data pooled together for this analysis basically represented all of the African-American samples from well-characterized individuals in the United States,” said Dr. Buckholtz. “Because large sample sizes are needed to conduct reliable genetic analyses, it is vitally important that African-Americans and people of other racial/ethnic groups participate in genetic studies supported by NIA.” He noted that broad collaboration and data-sharing efforts among researchers make such studies possible.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Neurodevelopmental Syndrome Identified
Study pinpoints underlying genetic mutations, raising hopes for targeted therapies.
Friday, April 22, 2016
New Link Between Obesity and Diabetes Found
Targeting a single enzyme that raises both sugar and insulin levels in the obese could prevent and treat diabetes.
Monday, November 25, 2013
Is There a Role for Vitamins in Cancer Prevention?
According to recent national surveys, approximately 40 percent of U.S. adults take multivitamins/multiminerals.
Monday, August 12, 2013
Study Reveals Genes That Drive Brain Cancer
About 15 percent of glioblastoma patients could receive personalized treatment with drugs currently used in other cancers.
Tuesday, August 06, 2013
Key Molecular Pathways Leading to Alzheimer’s Identified
Research approach highlights potential therapeutic targets.
Thursday, July 25, 2013
New Genetic Cause of Pulmonary Hypertension Identified
Study finds druggable target for rare fatal lung disease.
Thursday, July 25, 2013
Mutation Linked to Congenital Urinary Tract Defects
Findings point to new diagnostic category.
Thursday, July 18, 2013
Mouse Study Suggests Lead May Trigger Schizophrenia
Behavioral and MRI study in mice points to a synergistic relationship between lead exposure and schizophrenia gene.
Monday, June 10, 2013
Many Birth Defects in Heart Caused by Spontaneous Mutations
A study has found that at least 10 percent of cases stem from genetic mutations that occur spontaneously early in development.
Thursday, May 30, 2013
Common Childhood Asthma Not Rooted in Allergens, Inflammation
Discovery of origins of a unique form of asthma may lead to a precision medicine approach to treatment.
Friday, May 24, 2013
Looking for the Telltale Gene
A new genetic test allows parents to peer into their unborn children's medical future.
Friday, May 24, 2013
Hundreds of Alterations and Potential Drug Targets to Starve Tumors Identified
A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer.
Monday, April 22, 2013
Schizophrenia Gene Networks Found, and a Link to Autism
Although schizophrenia is highly genetic in origin, the genes involved in the disorder have been difficult to identify.
Thursday, November 15, 2012
New de novo Genetic Mutations in Schizophrenia Identified
Columbia University Medical Center (CUMC) researchers have identified dozens of new spontaneous genetic mutations that play a significant role in the development of schizophrenia, adding to the growing list of genetic variants that can contribute to the disease.
Thursday, October 04, 2012
New de novo Genetic Mutations in Schizophrenia Identified
Columbia University Medical Center (CUMC) researchers have identified dozens of new spontaneous genetic mutations that play a significant role in the development of schizophrenia, adding to the growing list of genetic variants that can contribute to the disease.
Thursday, October 04, 2012
Scientific News
Cell Transplant Treats Parkinson’s in Mice
A University of Wisconsin—Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell.
Understanding Female HIV Transmission
Glowing virus maps points of entry through entire female reproductive tract for first time.
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
A lncRNA Regulates Repair of DNA Breaks in Breast Cancer Cells
Findings give "new insight" into biology of tough-to-treat breast cancer.
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
Shape Of Tumor May Affect Whether Cells Can Metastasize
Illinois researchers found that the shape of a tumor may play a role in how cancer cells become primed to spread.
Computational Model Finds New Protein-Protein Interactions
Researchers at University of Pittsburgh have discovered 500 new protein-protein interactions (PPIs) associated with genes linked to schizophrenia.
MicroRNA Pathway Could Lead to New Avenues for Leukemia Treatment
Cancer researchers at the University of Cincinnati have found a particular signaling route in microRNA (miR-22) that could lead to targets for acute myeloid leukemia, the most common type of fast-growing cancer of the blood and bone marrow.
Analysis of Dog Genome will Provide Insight into Human Disease
An important model in studying human disease, the non-coding RNA of the canine genome is an essential starting point for evolutionary and biomedical studies – according to a new study led by The Genome Analysis Centre (TGAC).
New Insights into Gene Regulation
Researchers have solved the three-dimensional structure of a gene repression complex that is known to play a role in cancer.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!