Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Gene Linked to Migraine and Sleep Disorder

Published: Wednesday, May 15, 2013
Last Updated: Tuesday, May 14, 2013
Bookmark and Share
Research team took a closer look at the potential role of CKId in migraine.

Researchers linked an abnormal gene to both a common type of migraine and a rare sleep disorder. The finding offers insight into the mechanisms of migraines and provides a new avenue for exploring treatment options.

By some estimates, more than 1 in 10 people experience intense headaches, often accompanied by pulsing or throbbing pain, known as migraines.

About a third of migraine sufferers also experience visual or sensory disturbances known as migraine aura shortly before the headache begins.

Although the causes of migraine are poorly understood, the condition is known to run in families, and so genes likely play a role.

In earlier NIH-funded research, Dr. Louis J. Ptácek and his colleagues identified the gene responsible for a rare sleep disorder in a Vermont family. This family also tended to suffer from migraine with aura, which is how they originally came to medical attention.

The sleep disorder, called familial advanced sleep phase syndrome, drives people to be “early birds”-going to sleep and waking up unusually early each day.

Nearly a decade ago, Ptácek’s team showed that affected family members had mutations in an enzyme called casein kinase Iδ (CKIδ).

The enzyme plays a key role in sleep-wake cycles, or circadian rhythms, of species ranging from fruit flies to mice to people.

In the new study, a multicenter research team headed by Ptácek, who is at the University of California, San Francisco, took a closer look at the potential role of CKIδ in migraine.

Their research was funded in part by NIH’s National Heart, Lung and Blood Institute (NHLBI), National Institute of Neurological Disorders and Stroke (NINDS) and National Institute of General Medical Sciences (NIGMS). Results were published in Science Translational Medicine on May 1, 2013.

The researchers first analyzed the CKIδ gene in 14 members of the original family. Five who had identical mutations in the CKIδ gene also met the diagnostic criteria for migraine.

The scientists then sequenced the gene in blood samples from 70 additional families with the rare sleep disorder. One family had a slightly different mutation in the CKIδ gene.

In this family, too, all 5 members with CKIδ mutations had migraine, aura without migraine or probable migraine. In further analysis, the researchers showed that the CKIδ mutations in both families reduce the enzyme’s activity.

To investigate the gene’s effects on the body, the researchers created transgenic mice with the same CKIδ mutation found in the original family.

Several tests suggested that the mutant mice had many characteristics akin to human migraines. When treated with a migraine-triggering compound, the mice showed increased sensitivity to pain.

Imaging and electrophysiological studies showed waves of brain activity and brain artery dilation believed to be similar to what occurs during migraine auras in humans.

Studies by other groups have linked unusual forms of migraine to proteins involved in transporting ions across membranes. CKIδ codes for a different kind of protein that affects many biological pathways, which might now be studied as potential contributors to migraines.

“This is the first gene in which mutations have been shown to cause a very typical form of migraine,” says Ptácek. “It’s our initial glimpse into a black box that we don’t yet understand.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

The Genetics of Blood Pressure
Researchers have identifed areas of the genome associated with blood-pressure including 17 previously unknown loci.
Wednesday, September 21, 2016
Catalogue of Human Genetic Diversity Expands
The largest data set of human exomes to date has been assembled to better study seqence variants and their consequences.
Wednesday, September 07, 2016
$12.4M Awarded to Neural Regeneration Projects
The National Institutes of Health will fund six projects to identify biological factors that influence neural regeneration.
Friday, September 02, 2016
New Inflammatory Disease Discovered
NIH researchers have discovered a rare and potentially deadly disease - otulipenia - the mostly affects children.
Tuesday, August 23, 2016
Public Support for National Study
Survey shows the majority of respondents support or show willingness for national precision medicine study.
Thursday, August 18, 2016
Schizophrenia, Autism Share Genetic Causes
Monkey brain developmental atlas pinpoints when, where genes activate.
Tuesday, August 16, 2016
How Breast Cancers Resist Chemotherapy
Researchers discovered an unexpected way that breast cancers cells with mutant BRCA1 or BRCA2 genes acquire drug resistance and evade chemotherapies.
Wednesday, August 10, 2016
Mutations Linked to Immunotherapy Resistance
Researchers uncover mutations in tumors of three patients with advanced melanoma that allowed the tumors to become resistant to the immune checkpoint inhibitor pembrolizumab (Keytruda®).
Tuesday, August 09, 2016
Genetic Cause of Rare Pediatric Neuropathy Identified
NIH mouse study identifies the mechanism responsible for a rare form of pediatric neuropathy.
Thursday, August 04, 2016
Depression Genetics Insight from Crowd-Sourced Data
Genome sites liked to depression have been discovered from data shared by people who had purchased their genetic profiles online.
Tuesday, August 02, 2016
Uncovering a New Principle in Chemotherapy Resistance in Breast Cancer
The NIH study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1 or BRCA2 genes.
Thursday, July 21, 2016
NIH Funds Million-Person Medicine Study
NIH announces $55million in awards to build foundations for ambitious Cohort Program that aims to engage 1 million participants in lifestyle, environments and genetics research.
Friday, July 08, 2016
Largest-Ever Study of Breast Cancer Genetics in Black Women
The study will identify genetic factors that may underlie breast cancer disparities.
Thursday, July 07, 2016
Significant Expansion Of Data Available In The Genomic Data Commons
Cancer genomic profile information from 18,000 adult cancer patients will be added to the database.
Wednesday, June 29, 2016
Predicting Effective Drug Combinations For TB
Researchers analyzed gene regulatory networks to explain the effectiveness of an experimental drug combination against drug-resistant tuberculosis bacteria.
Wednesday, June 15, 2016
Scientific News
A Diversity of Genomes
New DNA from understudied groups reveals modern genetic variation, ancient population shifts.
Gene Could Reduce Female Mosquitoes
Virginia Tech researchers have found a gene that can reduce female mosquitoes over many generations.
Improving Crop Efficiency with CRISPR
New study of CRISPR-Cas9 technology from Virginia Tech shows potential to improve crop efficiency.
Examining mtDNA May Help Identify Unknown Ancestry That Influences Breast Cancer Risk
Researchers studying mtDNA in a group of triple negative breast cancer patients found that 13 percent of participants were unaware of ancestry that could influence their risk of cancer.
Bacteria Use Ranking Strategy to Fight Off Viruses
Researchers have explained why microbes store virus confrontation information sequentially, with most recent attacks first.
Gene Therapy Technique May Help Prevent Cancer Metastasis
Gene-regulating RNA molecules could help treat early-stage breast cancer tumors before they spread.
Enhancing Antibiotics to Defeat Resistant Bacteria
Scientists enhance ability of antibiotics to defeat resistant types of bacteria using molecules called PPMOs
The Genetics of Blood Pressure
Researchers have identifed areas of the genome associated with blood-pressure including 17 previously unknown loci.
Mosquito Genetics Determine Tastes
Study reveals mosuito's preference for human versus animal biting is determined by genetics.
Quadruple Helix DNA Aids Cancer Therapies
Researchers have identified the role that a four-stranded version of DNA may play in the role of cancer progression.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!