Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

SentoClone Significantly Strengthens its Global Patent Portfolio

Published: Friday, June 07, 2013
Last Updated: Friday, June 07, 2013
Bookmark and Share
New patents granted in Japan, the USA and Europe.

SentoClone International AB has announced that it has been granted additional patents in Japan, the US and Europe further reinforcing the global protection of its proprietary SentoClone® technology, an active patient specific cellular immunotherapy against cancer based on the ex vivo cultivation and activation of CD4+ T-cells.

The technology has advanced to Phase II clinical trials following Phase I and pilot studies in patients with colorectal and bladder cancer.

SentoClone International´s chairman Pingsheng Hu said, "We are determined to develop our SentoClone® technology as rapidly as possible so that it can become an effective patient specific cancer therapy without significant side effects for the broad range of cancer patients worldwide. The recent patents we have been granted in Japan, the US and Europe means we have very solid IP in all major markets in the field of sentinel node derived T-cells in cancer therapy. We believe this much stronger patent protection will allow us to attract development partners so that we can make this novel approach to cancer therapy available to the many patients globally who could benefit."

The SentoClone® technology builds on a unique approach whereby CD4+ T- helper cells, highly specific for the patient’s individual tumor, are extracted from the tumor’s draining lymph node (the sentinel node) and cultivated ex vivo in a GMP production facility before being returned to the patient via one single infusion.

During cultivation, the T-cells are stimulated with growth factors and re-activated with antigen from the patient’s individual tumor.

Once returned to the patient the T-cells induce effector cells of the immune system to attack the tumor tissue highly specifically, leaving other tissue unaffected.

Evidence indicates that the technology also generates a powerful long-term immunologic memory where T-cells are patrolling the body in a process called immunosurveillance.

To-date more than 200 patients with a range of cancers have been treated using this unique approach with no significant side effects being reported.

The safety profile, combined with its synergistic mode of action, suggest that SentoClone® technology could be an ideal addition to current or upcoming cancer treatment regimens.

The recent patents granted to SentoClone covering its Sentinel node-derived CD4 T-cell cancer therapy are as follows:
• In Japan, patent 5244610, titled “Improved method for expansion of tumour-reactive T-lymphocytes for immunotherapy in cancer” covers the process of ex vivo cultivation and activation of CD4+ T-cells. It is the Company´s second patent granted in Japan during 2013.
• In Europe, patent EP 1966370B1, titled “Method for obtaining T-lymphocytes” covers the use in cancer immunotherapy of T-cells derived from metastasis-draining lymph nodes (“metinel nodes”). It is the Company´s third European patent and is presently being validated in the major European countries.
• In the USA, patent US 8211425B2, titled “Method for treating disseminated cancer” is the Company´s sixth patent granted in the US and covers the use of metinel node T-cells in cancer immunotherapy.

SentoClone International holds 24 international patents, including these new grants, within eight families.

The portfolio comprises six patents in the USA, three patents in Europe and two patents in Japan.

In addition, SentoClone International’s Chinese parent company Jiangsu Sinorda Biomedicine Co. holds patents for the Chinese market.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
Alzheimer's Genetics Point To New Research Direction
A University of Adelaide analysis of genetic mutations which cause early-onset Alzheimer’s disease suggests a new focus for research into the causes of the disease.
Contagious Cancers Are Spreading in Shellfish
Direct transmission of cancer among some marine animals may be more common than once thought, suggests a new study published in Nature by researchers at Columbia University Medical Center (CUMC).
Contagious Cancers Are Spreading in Shellfish
Direct transmission of cancer among some marine animals may be more common than once thought, suggests a new study published in Nature by researchers at Columbia University Medical Center (CUMC).
Fix for 3-Billion-Year-Old Genetic Error
Researchers at The University of Texas at Austin have developed a fix that allows RNA to accurately proofread for the first time.
Higher Frequency of Huntington's Disease Mutations Discovered
University of Aberdeen study shows that the gene change that causes Huntington's disease is much more common than previously thought.
Revealing the Genetic Causes of Bowel Cancer
A landmark study has given the most detailed picture yet of the genetics of bowel cancer — the UK's fourth most common cancer.
The Epigenetic Influences of Chronic Pain
Researchers at Drexel University College of Medicine are aiming to identify new molecular mechanisms involved in pain.
Fighting Resistant Blood Cancer Cells
Biologists present new findings on chronic myeloid leukemia and possible therapeutic approaches.
Tumor Cells Develop Predictable Characteristics
Scientists have discovered that cancer cells at the edge of a tumor that are close to the surrounding environment are predictably different from the cells within the interior of the tumor.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!