Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Bristol Researchers Gain Funding for New Hip Osteoarthritis Gene Study

Published: Tuesday, June 11, 2013
Last Updated: Tuesday, June 11, 2013
Bookmark and Share
A team of researchers has been awarded £250,000 by medical research charity Arthritis Research UK.

The research team will use their three-year grant to look at which genes are associated with a person’s hip shape and which hip shapes are more likely to lead to osteoarthritis. The team hope their findings will lead to the development of new treatments targeting the genes responsible for causing the condition.

Osteoarthritis is the most common form of arthritis in adults, affecting around eight million people in the UK. Although the condition can affect any joint in a person’s body including the spine and knees, it is very common in the hips, and can affect one or both hips. Currently there is no effective treatment other than pain relief and, ultimately, joint replacement surgery.

People may be at greater risk of developing hip osteoarthritis if they have had hip problems at birth or abnormal hip development in childhood, such as Perthes’ disease. Physical work such as farming may also increase the risk.

Other risk factors linked to developing osteoarthritis are a person’s weight, age and sex, but there is also a strong genetic link. This team’s work has previously shown that there are specific hip shape elements which play an important role in the development of the condition in the hip.

Jonathan Tobias, Professor of Rheumatology in the School of Clinical Sciences, who is heading up the study with a Bristol-based team, said: “We already know that there are several different abnormalities of hip shape associated with osteoarthritis development. For example, it’s thought that hip deformity in babies can lead to osteoarthritis in later life. But we hope that by increasing our knowledge of this genetic component further, we’ll be able to better understand the disease and ultimately improve prevention and treatments for people living with it.”

Medical director of Arthritis Research UK, Professor Alan Silman, added “Osteoarthritis is a major health issue and can cause considerable pain and disability for many people. We’re therefore delighted to award funding to the team at the University of Bristol as their research offers us hope in better understanding the genes involved and it’s an important step forwards towards developing new and effective treatments for people.”


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Gene Variation Identified for Teen Binge-Eating
Researchers have identified a gene variant which can lead to teenage binge eating, they hope that their work will inform the development of future preventative measures.
Wednesday, July 22, 2015
Fighting Prostate Cancer with a Tomato-Rich Diet
New research suggests that men who eat over 10 portions of tomatoes a week have an 18% lower risk of developing prostate cancer.
Thursday, August 28, 2014
Breakthrough Shows How DNA is ‘Edited’ to Correct Genetic Diseases
An international team of scientists has made a major step forward in our understanding of how enzymes 'edit' genes, paving the way for correcting genetic diseases in patients.
Wednesday, May 28, 2014
Genome of 700,000-Year-Old Horse Sequenced
The oldest genome so far from a prehistoric creature has been sequenced by an international team.
Thursday, June 27, 2013
Protecting Genes, One Molecule at a Time
An international team of scientists have shown at an unprecedented level of detail how cells prioritise the repair of genes containing potentially dangerous damage.
Tuesday, September 11, 2012
Scientists Identify Mechanisms in Aspirin that Help Protect Against Cancer
Long-term usage of non-steroidal anti-inflammatory drugs can significantly reduce the risk of various cancers.
Monday, June 04, 2012
Doubling the Information from the Double Helix
Novel regulatory molecules called mirror-microRNAs control multiple aspects of brain function.
Monday, April 30, 2012
Genetics Confirm Bristol Theory on Neanderthals
The publication of the Neanderthal genome sequence this week in Science confirms the theory that there was gene flow from Neanderthals to Modern Humans.
Tuesday, May 11, 2010
Scientific News
RNAi Screening Trends
Understand current trends and learn which application areas are expected to gain in popularity over the next few years.
The Genetic Roots of Adolescent Scoliosis
Scientists at the RIKEN Center for Integrative Medical Sciences in collaboration with Keio University in Japan have discovered a gene that is linked to susceptibility of Scoliosis.
A Gene-Sequence Swap Using CRISPR to Cure Haemophilia
For the first time chromosomal defects responsible for hemophilia have been corrected in patient-specific iPSCs using CRISPR-Cas9 nucleases
New Tool Uses 'Drug Spillover' to Match Cancer Patients with Treatments
Researchers have developed a new tool that improves the ability to match drugs to disease: the Kinase Addiction Ranker (KAR) predicts what genetics are truly driving the cancer in any population of cells and chooses the best "kinase inhibitor" to silence these dangerous genetic causes of disease.
Understanding the Molecular Origin of Epigenetic Markers
Researchers at IRB Barcelona discover the molecular mechanism that determines how epigenetic markers influence gene expression.
New Tech Enables Epigenomic Analysis with a Mere 100 Cells
A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation, inflammation and cancer has been developed by researchers at Virginia Tech.
Access Denied: Leukemia Thwarted by Cutting Off Link to Environmental Support
A new study reveals a protein’s critical – and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer.
New Weapon in the Fight Against Blood Cancer
This strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
Toxin from Salmonid Fish has Potential to Treat Cancer
Researchers from the University of Freiburg decode molecular mechanism of fish pathogen.
Study Finds Non-Genetic Cancer Mechanism
Cancer can be caused solely by protein imbalances within cells, a study of ovarian cancer has found.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!