Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Sixteen New Genetic Regions for Allergies Discovered

Published: Monday, July 01, 2013
Last Updated: Monday, July 01, 2013
Bookmark and Share
Regions discovered during two of the largest genetic studies ever conducted on common allergies, including pollen, dust-mite and cat allergies.

Together they are responsible for at least 25 per cent of allergy in the population. Eight of the genetic variations have previously been associated with asthma. The discoveries, published today in Nature Genetics, are a major step towards understanding the biological basis of common allergies.

Allergies are very common. According to Allergy UK, around 21 million adults in the UK suffer from at least one allergy. The numbers are increasing every year and, in the UK, it is estimated that 50 per cent of all children are diagnosed with an allergic condition.

The first study, undertaken by the Early Genetics and Lifecourse Epidemiology research cohort (EAGLE), which includes Children of the 90s (ALSPAC) at the University of Bristol, involved almost 32,000 individuals from 16 studies worldwide.

The EAGLE study was conducted in two stages. The first compared 5,809 allergy sufferers with 9,875 non-allergy sufferers (controls). Allergy was assessed objectively by measuring allergen levels in blood or by a skin-prick test. The second phase replicated the study in 6,145 independent allergy sufferers and 10,137 controls.

Ten of the genetic locations were associated with self-reported allergy symptoms in an independent companion study of 53,000 individuals conducted by 23andMe, the American personal genetics company, and Children of the 90s.

Professor John Henderson from Children of the 90s, who was involved in the EAGLE study, said: "Allergy is an important component of many diseases, including asthma, eczema and hay fever, which together account for a huge burden on patients and the health services. This is a very exciting time for allergy research. Genetic discoveries have identified specific pathways of allergy development that are not shared with allergic diseases like asthma. Understanding these pathways could lead to eventual development of drugs that cure or prevent allergy rather than just suppressing its symptoms."

Dr David Hinds, 23andMe principal scientist who was involved in the 23andMe study said: "We’ve seen some substantial increases in prevalence of allergies and asthma. Although environmental factors certainly play a role, our study reinforces the genetic link between common allergens and a person’s susceptibility to experiencing an allergic reaction.

"Additionally, current estimates of the heritability of allergies are high, which suggests that understanding the genetic factors underlying allergic conditions may be key to understanding who might be most likely to suffer from allergies and how the condition might best be treated."

Dr Nic Timpson from Children of the 90s, who was involved in both studies, added: "One of the key features of this work is the demonstration that with a suitably sized study, the analysis of medically relevant questionnaire data alongside genetic variation has the potential to yield important information concerning the underlying biology of a complex outcome.

"Indeed, through a collaborative interaction with colleagues from EAGLE where specific tests of allergic sensitization were available, we were able to independently replicate many of the findings made here."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Manipulation of Protein Could Help Stop Spread of Cancer Cells
New findings, published in the Nature journal Oncogene, reveal how a protein, PRH, is normally able to prevent cells from unnecessary migration.
Monday, November 18, 2013
Random Walks on DNA
Scientists have revealed how a bacterial enzyme has evolved an energy-efficient method to move long distances along DNA.
Monday, April 22, 2013
Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Discovered Through ‘Big Data’ Analysis
Researchers at the SBP have identified over 100 new genetic regions that affect the immune response to cancer.
New Therapeutic Targets For Small Cell Lung Cancer Identified
Researchers at UTSW Medical Center have identified a protein termed ASCL1 that is essential to the development of small cell lung cancer and that, when deleted in the lungs of mice, prevents the cancer from forming.
Deciphering Inactive X Chromosomes
Untangling the Barr body of inactive X chromosomes valuable for understanding chromosome structure and gene expression.
Micro Disease-Detecting Senor Created
Researchers at McMaster University have created a microscopic disease-detecting sensor that can turn on to detect trace amounts of substances.
Liquid Biopsies Treating Ovarian Cancer
Researchers have discovered a promising monitor and treat recurrence of ovarian cancer. Detecting cancer long before tumours reappear.
Uncovering a New Principle in Chemotherapy Resistance in Breast Cancer
The NIH study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1 or BRCA2 genes.
Understanding Treatment Resistant Melanoma
Researchers have determined how advanced melanoma becomes resistant; a development toward developing treatments.
Investigating ‘Black Box’ of Human Genetics
Investigations into inactive X chromosomes have shown unusual DNA repeat elements are essential for maintaining 3D structure.
Liquid Biopsies: DNA Size Matters
Study finds circulating tumour DNA can be distinguished from healthy DNA through fragment size identification.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!