Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Research Finds New Genetic Links to Juvenile Arthritis

Published: Friday, July 05, 2013
Last Updated: Friday, July 05, 2013
Bookmark and Share
New research has identified 14 genes linked to juvenile idiopathic arthritis (JIA), the most common type of arthritis affecting children.

The new study brings the number of confirmed genes in JIA to 17 and represents an important advance toward better understanding and treatment of JIA.

Published in Nature Genetics, the international study used technology called the Immunochip array to analyze DNA samples from 2,816 children with JIA collected at more than 40 pediatric rheumatology clinics in the United States and Europe and 13,000 healthy controls to look for differences in genes, said Susan Thompson, Ph.D., a leader of the study and researcher in the Division of Rheumatology at Cincinnati Children's Hospital Medical Center. Carl D. Langefeld, Ph.D., a biostatistician at Wake Forest University School of Medicine in Winston-Salem, NC, led the team of statisticians completing this large analysis. In addition to the 14 new genes, the analyses confirmed three previously discovered genes and suggested that another 11 genetic regions might be involved in the disease.

JIA, an autoimmune disease, has several different, but related, forms. The genes studied were from children with two common JIA subtypes — polyarticular and oligoarticular. Many of the implicated genes are involved in the development, activation or differentiation of T cells — a type of white blood cell that identifies, attacks and rids the body of infectious agents.

Prior to this study only three genes — the human leukocyte antigen (HLA) region, PTPN22 and PTPN2 — had been shown to be involved in JIA, a disease that is believed to have both genetic and environmental components. The confirmation of those three genes, plus the finding of numerous others could have two important implications, said Thompson.

“If we can find a novel disease mechanism, that can inform drug design,” she said. Also, by comparing genes, scientists might further define disease subtypes, which could help doctors determine which children are most likely — or unlikely — to respond to a particular treatment before they try it. This knowledge, she said, could help with the development of treatment protocols.

The study, which took two years to complete and is the largest collaborative study of JIA to date, has opened the door to other collaborations that likely will provide more clues about JIA, according to Thompson. The next step, she said, is an analysis of DNA from 1,500 more patients to help understand or confirm the role of the 11 additional genetic regions identified as having a possible connection in the current study.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,600+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
Higher Frequency of Huntington's Disease Mutations Discovered
University of Aberdeen study shows that the gene change that causes Huntington's disease is much more common than previously thought.
Revealing the Genetic Causes of Bowel Cancer
A landmark study has given the most detailed picture yet of the genetics of bowel cancer — the UK's fourth most common cancer.
The Epigenetic Influences of Chronic Pain
Researchers at Drexel University College of Medicine are aiming to identify new molecular mechanisms involved in pain.
Fighting Resistant Blood Cancer Cells
Biologists present new findings on chronic myeloid leukemia and possible therapeutic approaches.
Tumor Cells Develop Predictable Characteristics
Scientists have discovered that cancer cells at the edge of a tumor that are close to the surrounding environment are predictably different from the cells within the interior of the tumor.
Mothers Obesity Could be Passed on in mtDNA
Obesity can predispose offspring in multiple generations to metabolic problems.
New Imaging Method Reveals Nanoscale Details about DNA
Enhancement to super-resolution microscopy shows orientation of individual molecules, providing a new window into DNA’s structure and dynamics.
Genetic Research Can Significantly Improve Drug Development
With drug development costs topping $1.2bn (£850 million) to get a single treatment to the point it can be sold and used in the clinic, could genetic analysis save hundreds of millions of dollars?
Naked Mole Rat Exhibits “Extraordinary” Cancer Resistance
Scientists are getting closer to understanding the anti-cancer mechanism of the naked mole rat by making induced pluripotent stem cells.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,600+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!