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Discovered Epigenetic Alterations in the Brain of Alzheimer's Patients

Published: Monday, September 16, 2013
Last Updated: Monday, September 16, 2013
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Alzheimer disease is becoming a major health problem in Western societies, exacerbated by the progressive aging of the population.

The neurological deterioration of these patients implies their isolation of the world, forget their family and friends , loss of memory, dementia and major health problems . Currently there is no effective treatment for this disease.

Although in a few cases there is a hereditary component, usually the cause is unknown. In this regard, alterations in the genome activity could be involved in the onset of disease. Today, the prestigious international journal Brain publishes a paper led by Manel Esteller, Director of the Cancer Epigenetics and Biology Biomedical Research Institute (IDIBELL) , ICREA researcher and Professor of Genetics at the University of Barcelona , which shows by first time the existence of epigenetic aberrations in the brain of Alzheimer's patients.

"We started studying the epigenetic differences of twelve different brain regions of mice. Among them we analyzed in greater depth the area of the head, the frontal cortex. We saw that when Alzheimer's was induced in these animals, the epigenetic chemical signal called DNA methylation changed" explained Manel Esteller, director of the study.

Esteller stresses that the same changes were repeated in the brains of Alzheimer patients. " In patients, epigenetic alterations affecting genes related to energy generation in neurons , formation of synapses ( the communication between neurons) and compasses that guide axons ( long tail neurons ) . "

According to Manel Esteller “this discovery is not only important to clarify the causes and biological basis of the disease,but to prove possible future treatments of it. In this sense, they are already using drugs with epigenetic effects in other diseases neurological disorders such as epilepsy.


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