Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Crown Bioscience Enter Into a Business Collaboration with Xstrahl Ltd

Published: Tuesday, October 15, 2013
Last Updated: Tuesday, October 15, 2013
Bookmark and Share
Development of radiation models of cancer will enable the discovery of more effective oncology therapies.

Crown Bioscience, Inc. has announced that it has entered into a collaboration with Xstrahl Ltd, a leading designer and manufacturer of X-Ray solutions for radiation biology research.

As part of the agreement, CrownBio will be implementing the SARRP research platform supplied by Xstrahl, based on Image Guided Micro-Irradiation (IGMI™) techniques at its PRECOS facility in Nottingham, UK.

As a result of the partnership, CrownBio will be at the forefront of providing contract research oncology models that provide an irradiation service based on targeted beam radiation therapy, to more closely mimic the clinical situation for patients in the preclinical setting to help improve potential cancer treatment regimens.

CrownBio is the largest supplier of oncology services, with a global footprint spanning three major continents in North America, Europe and Asia Pacific.

Via its collaboration with Xstrahl, the company is now able to offer its customers computerized tomography (CT) imaging with precise radiation delivery.

High resolution imaging enables researchers to pinpoint an exact clinical target and deliver a precise radiation dose to in vivo and in vitro models. The platform provides the ability to perform combination studies in patient derived xenograft (PDX) and cell line derived xenograft (CDX) models as well as in vitro, in addition to irradiated subjects for haematological or more fastidious models.

Jean-Pierre Wery, President of CrownBio comments, “The partnership represents CrownBio’s commitment to providing its pharmaceutical and biopharmaceutical customers with specialized techniques and services. Radiation therapy is part of the treatment regimen for the majority of cancer patients worldwide. Therefore providing preclinical models which more closely reflect a patient’s condition should be a potential option for validating the efficacy of novel therapies and potential compounds that make tumor cells more sensitive to radiation therapy (radiosensitizers) for the treatment of cancer. The use of the IGMI technique in conjunction with our commercial models will provide a unique portfolio of models which more closely mimic the treatment regimen in the clinic, but in the preclinical setting.”

CrownBio has unique clinically relevant models, which reflect the patient situation for each aspect of cancer progression, encompassing pre-cancerous lesions, primary tumors and metastasis.

Jean-Pierre Wery continues, “We are delighted to partner with Xstrahl in order to further develop unique cutting-edge models that represent patients who have undergone radiation therapy. Conventional chemotherapy has been, for many years, the prevalent type of anti-cancer treatment. However its broad-based mechanisms (e.g. DNA alkylating agents) usually lead to severe systemic side effects and it is becoming increasingly important to consider alternatives to chemotherapy, such as radiation.”

The SARRP platform is designed to close the gap between current clinical techniques and radiation biology/radiotherapy.

The platform enables researchers to confidently assess the efficacy and efficiency of current treatment regimes and provide new data to the medical community that can help to shape the future of radiation protocols and concurrent therapies.

Adrian Treverton - COO at Xstrahl Life Sciences said today, “This unique partnership with CrownBio will enable Xstrahl to enhance our understanding of unique models of radiation and apply this knowledge to the wider oncology drug discovery community. We want to transform the way researchers and clinicians conduct radiation research as well as providing the most advanced platforms for validating the efficacy of novel radiation therapies for cancer and research into normal tissue toxicity. Our expertise in targeted radiotherapy provides a perfect complement to CrownBio’s existing imaging services in order to enhance radiation oncology.”

Preclinical models in radiation oncology are essential tools for cancer research and therapeutics. CrownBio is looking to develop models that can be used to test radiation therapy, including in vitro as well as in vivo orthotopic xenograft models which can ultimately be used to develop more effective cancer therapies.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Crown Bioscience Announces U.S. Expansion
New service center will allow the expansion of new immunotherapy experimental platforms to advance translational medical research and the treatment of cancers.
Saturday, October 25, 2014
Crown Reveals Strategy for Combined Drug-IR Therapy to Overcome Resistance
Novel strategies for combining drug therapy with irradiation to deliver new hope for overcoming resistance in the clinic.
Saturday, June 21, 2014
Crown Bioscience Receives $26.55M Series D Funding
Investment will fund rapid expansion in translational platform technologies for oncology and metabolic diseases.
Monday, May 12, 2014
Crown Bioscience Announces Research Collaboration with the NRCMM
New collaboration aims to develop disease-specific experimental models for translational medical research.
Saturday, May 10, 2014
SIMM and Crown Bioscience Reach Landmark Agreement
Agreement to develop world-leading mouse clinical center and largest annotated PDX and translational oncology platform.
Friday, November 29, 2013
Scientific News
Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Genetic Tug of War
Researchers have reported on a version of genetic parental control in mice that is more targeted, and subtle than canonical imprinting.
Error Correction Mechanism in Cell Division
Cell biologists have reported an advance in understanding the workings of an error correction mechanism that helps cells detect and correct mistakes in cell division early enough to prevent chromosome mis-segregation and aneuploidy, that is, having too many or too few chromosomes.
How to Become a Follicular T Helper Cell
Uncovering the signals that govern the fate of T helper cells is a big step toward improved vaccine design.
Researchers Resurrect Ancient Viruses
Researchers at Massachusetts Eye and Ear and Schepens Eye Research Institute have reconstructed an ancient virus that is highly effective at delivering gene therapies to the liver, muscle, and retina.
Cell Aging Slowed by Putting Brakes on Noisy Transcription
Experiments in yeast hint at ways to extend life of some human cells.
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
Expanding the Brain
A team of researchers has identified more than 40 new “imprinted” genes, in which either the maternal or paternal copy of a gene is expressed while the other is silenced.
Identifying a Key Growth Factor in Cell Proliferation
Researchers discover that aspartate is a limiter of cell proliferation.
Study Uncovers Target for Preventing Huntington’s Disease
Scientists from Cardiff University believe that a treatment to prevent or delay the symptoms of Huntington’s disease could now be much closer, following a major breakthrough.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!