Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

The Role of Mass Spectrometry in the "Omics" Era

Published: Tuesday, February 18, 2014
Last Updated: Tuesday, February 18, 2014
Bookmark and Share
The tremendous developments of the MS technology and concurrent gene sequencing efforts have made the “-omic” revolution possible.

Abstract
Mass spectrometry (MS) is one of the key analytical technology on which the emerging ''-omics'' approaches are based. It may provide detection and quantization of thousands of proteins and biologically active metabolites from a tissue, body fluid or cell culture working in a ''global'' or ''targeted'' manner, down to ultra-trace levels. It can be expected that the high performance of MS technology, coupled to routine data handling, will soon bring fruit in the request for a better understanding of human diseases, leading to new molecular biomarkers, hence affecting drug targets and therapies. In this review, we focus on the main advances in the MS technologies, influencing genomics, transcriptomics, proteomics, lipidomics and metabolomics fields, up to the most recent MS applications to meta-omic studies.

The full article is published online in Current Organic Chemistry and is free to access.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

The Genetics Behind Abdominal Pigmentation in Drosophila melanogaster
This study by researchers at the North Carolina State University provides evidence that genetic variation at a number of steps in regulatory, developmental, and transport pathways may contribute to natural variation in abdominal pigmentation.
Wednesday, May 06, 2015
Mosquitoes Resistant to DDT Also Resistant to Mosquito Net Insecticide
Understanding how resistance works will help to develop tests, stopping resistance genes from spreading amongst mosquito populations.
Thursday, February 27, 2014
Epigenetic Regulation of ADME-Related Genes: Focus on Drug Metabolism and Transport
As research in epigenetic regulation of ADME genes progresses, there are many opportunities and challenges in understanding the epigenetic mechanisms in drug metabolism and disposition.
Monday, September 23, 2013
Applications of Metabolomics in Cancer Research
This review focuses on specific areas within cancer and carcinogenesis research on which metabolomics has been brought to bear.
Monday, July 22, 2013
Identification of Plasma Lipid Biomarkers for Prostate Cancer by Lipidomics and Bioinformatics
This study explores a new approach to seeking biomarkers for prostate cancer and other diseases.
Monday, April 08, 2013
'Omics' Approaches to Understanding Interstitial Cystitis/Painful Bladder Syndrome/Bladder Pain Syndrome
This review describes the current state of 'omics' studies and available data sets relevant to IC/PBS/BPS.
Monday, March 11, 2013
Systems Biology Approaches and Applications in Obesity, Diabetes, and Cardiovascular Diseases
This article summarizes systems biology methodologies that can produce novel mechanistic insights, identify disease biomarkers, and uncover potential therapeutic targets from a combination of omics datasets.
Thursday, February 21, 2013
Anti-cancer Drug Discovery and Development: Bcl-2 Family Small Molecule Inhibitors
In this article, researchers from The Pennsylvania University College of Medicine discuss the current status of Bcl-2 family small molecule inhibitors in preclinical and clinical development.
Thursday, January 31, 2013
Remodeling of Central Metabolism in Invasive Breast Cancer Compared to Normal Breast Tissue
Researchers from Charité University Hospital have constructed the first comprehensive metabolic map of breast cancer by GC-TOF analysis of a large cohort of breast cancer and normal tissues.
Friday, September 07, 2012
SIGLa: An Adaptable LIMS for Multiple Laboratories
SIGLa has been developed with the aim of contributing to complex data management in the laboratory by managing large amounts of data and guaranteeing its consistency.
Monday, August 20, 2012
Genomic Assessment of Human Cumulus Cell Marker Genes
Study includes the investigation of the impact of technical and biological variability such as qPCR series and patients on the level of gene expression.
Thursday, August 02, 2012
MALDI Imaging Mass Spectrometry for In Situ Proteomic Analysis of Preneoplastic Lesions in Pancreatic Cancer
Researchers from Technische Universität München have shown MALDI-IMS on sections from endogenous mouse models of PDAC is a valuable approach for proteomic investigations of diseased tissue.
Monday, July 16, 2012
Prediction of Gastric Cancer Metastasis through Urinary Metabolomic Investigation using GC/MS
This aim of this article is to gain new insights into tumor metabolism and to identify possible biomarkers with potential diagnostic values to predict tumor metastasis.
Monday, July 16, 2012
New Study using Large-scale Gene Expression Microarray Analysis
Pharmacological unmasking microarray approach-based discovery of novel DNA methylation markers for hepatocellular carcinoma.
Friday, June 15, 2012
Genotyping Performance Between Saliva and Blood-derived Genomic DNAs on the DMET Array
Study also evaluates possible ways to improve the saliva-derived DNA genotyping call rate.
Friday, June 15, 2012
Scientific News
Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Watching a Tumour Grow in Real-Time
Researchers from the University of Freiburg have gained new insight into the phases of breast cancer growth.
Childhood Cancer Cells Drain Immune System’s Batteries
Cancer cells in neuroblastoma contain a molecule that breaks down a key energy source for the body’s immune cells, leaving them too physically drained to fight the disease.
Urine Proteins Point to Early-Stage Pancreatic Cancer
A combination of three proteins found at high levels in urine can accurately detect early-stage pancreatic cancer, researchers at the BCI have shown.
Researcher Discovers Trigger of Deadly Melanoma
New research sheds light on the precise trigger that causes melanoma cancer cells to transform from non-invasive cells to invasive killer agents, pinpointing the precise place in the process where "traveling" cancer turns lethal.
Genetic Tug of War
Researchers have reported on a version of genetic parental control in mice that is more targeted, and subtle than canonical imprinting.
Error Correction Mechanism in Cell Division
Cell biologists have reported an advance in understanding the workings of an error correction mechanism that helps cells detect and correct mistakes in cell division early enough to prevent chromosome mis-segregation and aneuploidy, that is, having too many or too few chromosomes.
How to Become a Follicular T Helper Cell
Uncovering the signals that govern the fate of T helper cells is a big step toward improved vaccine design.
Researchers Resurrect Ancient Viruses
Researchers at Massachusetts Eye and Ear and Schepens Eye Research Institute have reconstructed an ancient virus that is highly effective at delivering gene therapies to the liver, muscle, and retina.
Cell Aging Slowed by Putting Brakes on Noisy Transcription
Experiments in yeast hint at ways to extend life of some human cells.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!