Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

$3M NIH Grant Enables Baylor International HIV/AIDS Program

Published: Wednesday, February 19, 2014
Last Updated: Wednesday, February 19, 2014
Bookmark and Share
Researchers to study genetic differences of disease in sub-Saharan African children.

A $3 million, three-year grant from the National Institutes of Health will enable researchers from the Baylor International Pediatric AIDS Initiative at Texas Children’s Hospital to study the genetic factors that affect the progression of tuberculosis and HIV in one of the largest populations infected with the diseases yet to be studied– children in sub-Saharan Africa.

The grant will establish The Collaborative African Genomics Network (CAfGEN) and include collaborators from two BIPAI sites - the Botswana-Baylor Children’s Centre of Excellence and the Baylor-Uganda Children’s Clinical Center of Excellence, along with Makerere University in Uganda, the University of Botswana, and Baylor College of Medicine.  

Working to improve treatments
“Advanced genetic and genomic technologies have the promise to transform our understanding and approach to health and human diseases,” said Dr. Graeme Mardon, professor of molecular and human genetics and pathology & immunology at Baylor and principal investigator of the Baylor portion of the grant.

The team will use state-of-the-art genomic technologies to study a rare group of HIV-infected children who can control the infection for years without needing anti-retroviral therapy to prevent AIDS. They will also be following a group of HIV positive children infected with tuberculosis to identify new genes associated with disease progression.

Their ultimate goal is to offer improved diagnostics and new therapeutic avenues in tuberculosis and HIV/AIDS.

“Most of the previous genetic studies in HIV were undertaken in non-African, adult populations,” said Dr. Gabriel Anabwani, executive director of the Botswana-Baylor Children’s Center of Excellence and the lead principal investigator of the grant. “There is a great need to study the genetic factors of progression in children; their disease differs considerably from their adult counterparts and they potentially have more to gain from therapeutic advances.”

Genomic expertise
The clinical centers will provide expertise for patient recruitment while the universities will provide local molecular genetic resources. Baylor, home to one of the top-rated genetics programs in the United States, will bring to the partnership access to genomics expertise and resources that will ultimately be transitioned to African researchers and institutions through an extensive training program designed to develop highly-knowledgeable geneticists in African nations.

Other principal investigators include Drs. Oathokwa Nkomazana and Sununguko Mpoloka from the University of Botswana; Dr. Moses Joloba from Makerere University; and Dr. Adeodata Kekitiinwa from the Baylor-Uganda Children’s Clinical Center of Excellence. Other key Baylor investigators include Dr. Neil Hanchard, assistant professor of molecular and human genetics, and Dr. Chester Brown, associate professor of molecular and human genetics and of pediatrics.

The grant will also help establish core genomics facilities in Botswana and Uganda, with trainees from those institutions having the chance to work in several highly-regarded core laboratories at BCM including the Human Genome Sequencing Center, the Laboratory for Translational Genomics in the Children’s Nutrition Research Center, and the Center for Statistical Genetics.

“The excitement of this grant is not only the potential for improved care in childhood HIV, but the improvements in knowledge and infrastructure that will serve the people of Africa for many years to come,” said Kekitiinwa. 

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Baylor, DNAnexus Collaborate
Partnership sets out to develop HgV, a new iteration of HGSC's Mercury, a BCM-developed data processing and variant calling pipeline for analyzing and annotating next-generation sequencing data in research and clinical contexts.
Tuesday, June 23, 2015
Baylor, TGen Collaborate on Personalized Cancer Treatment Options
The companies will collaborate on precision medicine for cancer patients by offering liquid biopsies, performing gene sequencing, conducting clinical trials, and creating personalized vaccines.
Tuesday, May 26, 2015
Collaboration Unravels Novel Mechanism for Neurological Disorder
The novel gene (CLP1) associated with a neurological disorder affecting both the peripheral and central nervous systems.
Saturday, April 26, 2014
Baylor College of Medicine, Berry Genomics Co. Seek to Improve on Prenatal Genetic Tests
Teams aim to improve prenatal genetic testing by combining BCM’s expertise in using microarrays for DNA analysis and Berry’s non-invasive technology evaluating fetal DNA in maternal plasma.
Monday, January 07, 2013
Protein 'Tubules' Free Avian Flu Virus from Immune Recognition
Two domains or portions of the protein NS1 combine to form tiny tubules where double-stranded RNA is hidden from the immune system, researchers say.
Friday, November 07, 2008
Lack of Fragile X, Related Gene Disrupts Sleep
Deficiency of the FMR1 gene and a similar gene called FXR2 could account for sleep problems associated with inherited mental impairment.
Friday, June 27, 2008
Nature Mixes, Matches Genes to Keep Nerve Cells Straight
BCM researchers report that nature has to mix and match thousands of genes to generate the myriad types of neurons needed to assemble the brain and nervous system.
Thursday, June 12, 2008
Findings Indicate How Gene Transcription is Controlled in Embryonic Stem Cells
In a report that appears in the journal Nature Cell Biology, BCM researchers explain that association determines fate in embryonic stem cells.
Monday, May 05, 2008
Notch Controls Bone Formation and Strength
Notch, a protein that governs cell differentiation process in embryos, plays a critical role in bone formation and strength later in life.
Monday, February 25, 2008
Epilepsy Genes may Cancel Each Other
Inheriting two genetic mutations that can individually cause epilepsy might actually be "seizure-protective," according to Baylor College of Medicine researchers.
Tuesday, November 06, 2007
BCM Human Microbiome Projects to Sequence 150 Bacteria, Sample Human Metagenome
A $2.3 million NHGRI grant will enable researchers to determine the genetic code of bacteria that colonize healthy humans and study the structure of microbial communities from five regions of the human body.
Tuesday, November 06, 2007
Scientific News
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Biologists Induce Flatworms to Grow Heads and Brains of Other Species
Findings shed light on role of a new kind of epigenetic signaling in evolution, could yield clues for understanding birth defects and regeneration.
Turning up the Tap on Microbes Leads to Better Protein Patenting
Mining millions of proteins could become faster and easier with a new technique that may also transform the enzyme-catalyst industry, according to University of California, Davis, researchers.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Tardigrade's Are DNA Master Thieves
Tardigrades, nearly microscopic animals that can survive the harshest of environments, including outer space, hold the record for the animal that has the most foreign DNA.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Farming’s in Their DNA
Ancient genomes reveal natural selection in action.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos