Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Osteoporosis Drug May Treat Breast and Liver Cancers

Published: Thursday, February 20, 2014
Last Updated: Thursday, February 20, 2014
Bookmark and Share
Study from OSU has shown a drug used to prevent and treat osteoporosis in post-menopausal women may also be able to treat some breast and liver cancers.

Although clinical trials on patients are still needed, in lab tests researchers found that the drug raloxifene, which is marketed under the brand name Evista by Eli Lilly and Co., killed human breast cancer cells that are "triple-negative” as well as liver cancer cells.

Triple-negative breast cancers represent about 15-20 percent of all breast cancers in the United States and are more common in younger and African-American women, according to a factsheet from the Susan G. Komen organization. Chemotherapy, radiation and surgery are the preferred treatments because triple-negative breast cancers don't respond to typical medications like tamoxifen or trastuzumab. That's because their cells lack receptors for estrogen, progesterone and a protein known as human epidermal growth factor receptor 2.

Receptors, which are proteins in or on cells, are like a lock. Hormones act like keys to these receptors to unlock different cellular functions. For example, estrogen causes uncontrolled proliferation of breast cancer cells by binding to a receptor. It's known that raloxifene blocks estrogen from binding to its receptor and thus keeps breast cancer cells from multiplying.

But what OSU researchers discovered is that raloxifene also binds with a protein called the aryl hydrocarbon receptor (AhR) and kills cancer cells that do not have receptors for estrogen, said Ed O’Donnell, a postdoctoral scholar at OSU who conducted the research.

O’Donnell also analyzed survival data on women who had breast cancers that didn't require hormones to fuel the proliferation of the tumor cells. He found an increased survival rate in the women whose breast cancers had higher levels of the AhR protein.

"Our findings are exciting for two reasons," said OSU cancer researcher Siva Kolluri, who led the research, which was published in the journal Cell Death and Disease. "No. 1, our research revealed that we can target a specific protein, the AhR, to potentially develop new drugs for liver cancer and a subset of stubborn breast cancers. That's a major goal of our lab. No. 2, we discovered that raloxifene, a known drug, could potentially be repurposed to treat two distinct types of cancers."

The U.S. Food and Drug Administration approved raloxifene for use in bone loss prevention in post-menopausal women in 1997. In 1999, it was approved for treating postmenopausal women with osteoporosis. In 2007, the agency approved the use of raloxifene for reducing the risk of invasive breast cancer in post-menopausal women with osteoporosis and in post-menopausal women at high risk for invasive breast cancer, which spreads outside the lobules or milk ducts into surrounding breast tissue.

Raloxifene again hit the news in January when the federal government announced that most health insurance plans will be required to offer the prescription medicine at no cost to women who have an increased risk of developing breast cancer.

The OSU research article is called "The Aryl Hydrocarbon Receptor Mediates Raloxifene-induced Apoptosis in Estrogen Receptor Negative Hepatoma and Breast Cancer Cells." It is online at http://hdl.handle.net/1957/45321. OSU researcher William Bisson was a co-author on the paper.

The research was funded by the American Cancer Society, National Institute of Environmental Health Sciences and the U.S. Department of Defense Breast Cancer Research Program.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Red Wine Antioxidant May Provide New Cancer Therapy Options
Resveratrol and quercetin, two polyphenols that have been widely studied for their health properties, may soon become the basis of an important new advance in cancer treatment,
Monday, July 20, 2015
OSU Researchers Develop new Approach for Studying Tissue Regeneration
Researchers at Oregon State University have shed new light on the process of tissue regeneration in zebrafish.
Tuesday, November 06, 2007
Scientific News
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Searching Big Data Faster
Theoretical analysis could expand applications of accelerated searching in biology, other fields.
Growing Hepatitis C in the Lab
Recent discovery allows study of naturally occurring forms of hepatitis C virus (HCV) in the lab.
Inciting an Immune Attack on Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Reprogramming Cancer Cells
Researchers on Mayo Clinic’s Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy.
Genetic Overlapping in Multiple Autoimmune Diseases May Suggest Common Therapies
CHOP genomics expert leads analysis of genetic architecture, with eye on repurposing existing drugs.
Surprising Mechanism Behind Antibiotic-Resistant Bacteria Uncovered
Now, scientists at TSRI have discovered that the important human pathogen Staphylococcus aureus, develops resistance to this drug by “switching on” a previously uncharacterized set of genes.
How DNA ‘Proofreader’ Proteins Pick and Edit Their Reading Material
Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have discovered how two important proofreader proteins know where to look for errors during DNA replication and how they work together to signal the body’s repair mechanism.
Fat in the Family?
Study could lead to therapeutics that boost metabolism.
Tissue Bank Pays Dividends for Brain Cancer Research
Checking what’s in the bank – the Brisbane Breast Bank, that is – has paid dividends for UQ cancer researchers.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!