Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Breakthrough Profiling Technology to Improve Cancer Treatment on a Personalized Basis

Published: Saturday, April 12, 2014
Last Updated: Saturday, April 12, 2014
Bookmark and Share
New research paper published in the peer reviewed journal PLOS ONE.

The possibility of patients with pancreatic cancer being able to have their cancer tissue ‘profiled’ to understand how they will react to different treatments before they are given to them has moved a lot closer, a new research paper shows, published in the peer reviewed journal PLOS ONE.

This will enable more accurate profiling and the best drug selection for each individual. Trials are being planned to undertake the final stage of the process.

A recent study by UK Biosciences company, Proteome Sciences plc, in collaboration with leading academic partners King’s College Hospital, Imperial College London and the University of Cardiff, has shown this new method of analysis, using a system known as ‘SysQuant’ developed by Proteome Sciences, can unravel the chain of complex molecular activity that leads to and propagates cancer and be used to accurately predict how specific drug treatments will affect different patients with pancreatic cancer.

This new technique, which does not increase the overall cost of treatment, will provide doctors with information that will allow them to select which therapy will best work on an individual patient using existing medicines, something which to date has not been possible to achieve in most types of cancer. The researchers hope this will soon be applied across all cancers.

In the study, tumour, or cancerous tissue from 12 pancreatic cancer patients was analyzed involving over 2,100 proteins and 6,284 unique phosphorylation sites (which are common in modulating the activity of cancer suppressing proteins) being surveyed in each sample.

Commenting on this study, Professor Nigel Heaton, Professor of ‎Professor of Liver Transplant, Hepatobiliary and Pancreatic Surgery at King’s College Hospital said: “Cancer is caused by a chain reaction of many different chemicals in the body. Treatment looks to disrupt that chain reaction but how we do this can vary hugely from one person to the next.

“Understanding the chemical make-up of an individual patient will help us understand which patients will respond to treatment. At the moment, only 20% of patients will respond to standard treatment for pancreatic cancer so this new technology will help us predict beforehand which patients are most likely to respond and which will not.

“If we know what treatments will be the most effective before we administer them this gives us a huge advantage to help patients as well as save the NHS money by eliminating spending on treatments that won’t work.

Heaton continued, “It is a hugely promising step forward, not just for patients with pancreatic cancer, but for all people with cancer.”

Dr. Debashis Sarker, Senior Lecturer and Consultant in Medical Oncology at Kings College Hospital, London added: “The PLOS ONE paper shows the critical cancer proteins and pathways that are deregulated for each patient in pancreatic cancer using SysQuant. These differ from patient to patient indicating the need for a personalized approach to each patient’s treatments. Clinical trials should now be designed to compare standard therapy approaches compared to matching aberrant protein pathways with specific targeted therapies.”

Professor Justin Stebbing, Professor of Cancer Medicine and Medical Oncology, Consultant Oncologist, Imperial College London and Imperial College Healthcare NHS Trust said: "This work demonstrates the network of interactions, the fingerprint and signature of phosphorylation events in cancer. It provides an opportunity to study some of the major tumorigenic events in a test tube using the very latest in mass spectrometry-based technologies. This is the way forwards in cell signalling".

Referring to the study, Dr. Ian Pike, Chief Operating Officer at Proteome Sciences, commented: “This study is the first peer-reviewed article using the SysQuant® technology, which in this case identified the common and unique molecular events involved in pancreatic cancer. The results clearly demonstrate the potential to significantly improve the way bespoke treatments can be matched to each individual patient, prior to the administration of any drugs, using already approved medicines.

Dr. Pike continued, “This technology can also be used for the analysis of tissues across a range of different diseases including all other cancers. Furthermore it can be utilized to assess drugs which are in pre-clinical development much more efficiently and cost effectively than is currently possible.”

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Proteome Sciences to Develop Cancer Pathway Profiling Assays
New MS3 TMT® mass spectrometry technique to determine relative quantitation of proteins in multiple samples simultaneously.
Monday, June 17, 2013
Scientific News
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Biologists Induce Flatworms to Grow Heads and Brains of Other Species
Findings shed light on role of a new kind of epigenetic signaling in evolution, could yield clues for understanding birth defects and regeneration.
Turning up the Tap on Microbes Leads to Better Protein Patenting
Mining millions of proteins could become faster and easier with a new technique that may also transform the enzyme-catalyst industry, according to University of California, Davis, researchers.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Tardigrade's Are DNA Master Thieves
Tardigrades, nearly microscopic animals that can survive the harshest of environments, including outer space, hold the record for the animal that has the most foreign DNA.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Farming’s in Their DNA
Ancient genomes reveal natural selection in action.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos