Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

VolitionRx Announces First Published Data in Anticancer Research Journal

Published: Wednesday, April 30, 2014
Last Updated: Wednesday, April 30, 2014
Bookmark and Share
The preliminary data, which demonstrated high detection rates for colorectal cancer, was the first to be publicly shared by the company last year

VolitionRx Limited announces that preliminary data from University Hospital Bonn, Germany, has been published online in the leading peer-reviewed journal, Anticancer Research. The data, first presented at CNAPS (Circulating Nucleic Acids in Plasma and Serum) congress last year, shows VolitionRx’s single proprietary NuQ®-5mc assay detects 75% of colorectal cancers with 70% specificity. Since then, VolitionRx has achieved even better detection rates by combining its assays. The full article, “Novel Serum Nucleosomics Biomarkers for the Detection of Colorectal Cancer” is available on VolitionRx’s website. 

The independent trial at University Hospital Bonn was coordinated by Dr. Stefan Holdenrieder at the Institute of Clinical Chemistry and Clinical Pharmacology. Using VolitionRx’s NuQ® assay, his team tested 90 patient samples and found significantly lower levels of nucleosomes containing methylated DNA in the blood of patients with colorectal cancer compared to healthy samples, and later validated the results in a second set of 113 people.

Last year, VolitionRx proved that it could further improve detection rates by searching for more than one nucleosome biomarker and effectively creating a ‘panel’ test.  Using samples from CHU Dinant Godinne/UCL Namur Hospital in Belgium, the team detected 85% of colorectal cancer with 85% specificity when combining two NuQ assays. 

“It is encouraging to see data supporting the use of our blood tests for the detection of colorectal cancer being published for the very first time; it is a pivotal moment for us. Dr. Holdenrieder’s study was the first to acknowledge the potential of our NuQ tests,” said Jake Micallef, Chief Scientific Officer of VolitionRx. “It’s promising that similar results have been found independently from our own trials as we look to bring the test to market.”

Dr. Holdenrieder comments, “We are very excited to have our study published in such a prestigious journal. Since this study, we have seen more and more data confirming our findings and I am eager to ensure that this bank of research continues to grow so that patients can gain access to this rapid diagnostic tool as soon as possible. As such, I recently agreed to lead a performance evaluation study for VolitionRx’s CE mark application process.”

Other clinical trials assessing the effectiveness of VolitionRx’s assays include:

• A 4,800 patient retrospective study and an 11,000 patient prospective study into colorectal cancer at Hvidovre Hospital, University of Copenhagen, Denmark
• A 4,000 patient prospective study that involves patients with the 20 most prevalent cancers at University Hospital in Bonn, Germany
• A 250 patient study into colorectal cancer at CHU-UCL Mont Godinne Hospital, Belgium


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Assessing the Effectiveness of Genome-Editing Technologies
Researchers have developed a cost-effective and rapid method for assessing edits generated by CRISPR-Cas9 and other genome-editing technologies.
New Cancer Drug Target Found in Dual-Function Protein
Findings from a study from TSRI have shown that targeting a protein called GlyRS might help to halt cancer growth.
Alzheimer's Genetics Point To New Research Direction
A University of Adelaide analysis of genetic mutations which cause early-onset Alzheimer’s disease suggests a new focus for research into the causes of the disease.
Contagious Cancers Are Spreading in Shellfish
Direct transmission of cancer among some marine animals may be more common than once thought, suggests a new study published in Nature by researchers at Columbia University Medical Center (CUMC).
Contagious Cancers Are Spreading in Shellfish
Direct transmission of cancer among some marine animals may be more common than once thought, suggests a new study published in Nature by researchers at Columbia University Medical Center (CUMC).
Fix for 3-Billion-Year-Old Genetic Error
Researchers at The University of Texas at Austin have developed a fix that allows RNA to accurately proofread for the first time.
Higher Frequency of Huntington's Disease Mutations Discovered
University of Aberdeen study shows that the gene change that causes Huntington's disease is much more common than previously thought.
Revealing the Genetic Causes of Bowel Cancer
A landmark study has given the most detailed picture yet of the genetics of bowel cancer — the UK's fourth most common cancer.
The Epigenetic Influences of Chronic Pain
Researchers at Drexel University College of Medicine are aiming to identify new molecular mechanisms involved in pain.
Fighting Resistant Blood Cancer Cells
Biologists present new findings on chronic myeloid leukemia and possible therapeutic approaches.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!