Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

VolitionRx Announces First Published Data in Anticancer Research Journal

Published: Wednesday, April 30, 2014
Last Updated: Wednesday, April 30, 2014
Bookmark and Share
The preliminary data, which demonstrated high detection rates for colorectal cancer, was the first to be publicly shared by the company last year

VolitionRx Limited announces that preliminary data from University Hospital Bonn, Germany, has been published online in the leading peer-reviewed journal, Anticancer Research. The data, first presented at CNAPS (Circulating Nucleic Acids in Plasma and Serum) congress last year, shows VolitionRx’s single proprietary NuQ®-5mc assay detects 75% of colorectal cancers with 70% specificity. Since then, VolitionRx has achieved even better detection rates by combining its assays. The full article, “Novel Serum Nucleosomics Biomarkers for the Detection of Colorectal Cancer” is available on VolitionRx’s website. 

The independent trial at University Hospital Bonn was coordinated by Dr. Stefan Holdenrieder at the Institute of Clinical Chemistry and Clinical Pharmacology. Using VolitionRx’s NuQ® assay, his team tested 90 patient samples and found significantly lower levels of nucleosomes containing methylated DNA in the blood of patients with colorectal cancer compared to healthy samples, and later validated the results in a second set of 113 people.

Last year, VolitionRx proved that it could further improve detection rates by searching for more than one nucleosome biomarker and effectively creating a ‘panel’ test.  Using samples from CHU Dinant Godinne/UCL Namur Hospital in Belgium, the team detected 85% of colorectal cancer with 85% specificity when combining two NuQ assays. 

“It is encouraging to see data supporting the use of our blood tests for the detection of colorectal cancer being published for the very first time; it is a pivotal moment for us. Dr. Holdenrieder’s study was the first to acknowledge the potential of our NuQ tests,” said Jake Micallef, Chief Scientific Officer of VolitionRx. “It’s promising that similar results have been found independently from our own trials as we look to bring the test to market.”

Dr. Holdenrieder comments, “We are very excited to have our study published in such a prestigious journal. Since this study, we have seen more and more data confirming our findings and I am eager to ensure that this bank of research continues to grow so that patients can gain access to this rapid diagnostic tool as soon as possible. As such, I recently agreed to lead a performance evaluation study for VolitionRx’s CE mark application process.”

Other clinical trials assessing the effectiveness of VolitionRx’s assays include:

• A 4,800 patient retrospective study and an 11,000 patient prospective study into colorectal cancer at Hvidovre Hospital, University of Copenhagen, Denmark
• A 4,000 patient prospective study that involves patients with the 20 most prevalent cancers at University Hospital in Bonn, Germany
• A 250 patient study into colorectal cancer at CHU-UCL Mont Godinne Hospital, Belgium

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Biologists Induce Flatworms to Grow Heads and Brains of Other Species
Findings shed light on role of a new kind of epigenetic signaling in evolution, could yield clues for understanding birth defects and regeneration.
Turning up the Tap on Microbes Leads to Better Protein Patenting
Mining millions of proteins could become faster and easier with a new technique that may also transform the enzyme-catalyst industry, according to University of California, Davis, researchers.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Tardigrade's Are DNA Master Thieves
Tardigrades, nearly microscopic animals that can survive the harshest of environments, including outer space, hold the record for the animal that has the most foreign DNA.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Farming’s in Their DNA
Ancient genomes reveal natural selection in action.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos