Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Polar Bear Genome Gives New Insight Into Adaptations to High-fat Diet

Published: Thursday, May 15, 2014
Last Updated: Thursday, May 15, 2014
Bookmark and Share
A comparison of the genomes of polar bears and brown bears reveals that the polar bear is a much younger species than previously believed, having diverged from brown bears less than 500,000 years ago.

The genes pinpointed by the study are related to fatty acid metabolism and cardiovascular function, and may explain the bear’s ability to cope with a high-fat diet while avoiding fatty plaques in their arteries and the cardiovascular diseases that afflict humans with diets rich in fat. These genes may provide insight into how to protect humans from the ill effects of a high-fat diet.

The study was a collaboration between Danish researchers, led by Eske Willerslev and including Rune Dietz, Christian Sonne and Erik W. Born, who provided polar bear blood and tissue samples; and researchers at BGI in China, including Shiping Liu, Guojie Zhang and Jun Wang, who sequenced the genomes and analyzed the data together with a team of UC Berkeley researchers, including Eline Lorenzen, Matteo Fumagalli and Rasmus Nielsen. Nielsen is a UC Berkeley professor of integrative biology and of statistics.

Postdoc Eline Lorenzen dressed for Arctic weather while taking tissue samples of polar bears in Greenland.

“For polar bears, profound obesity is a benign state,” said Lorenzen, one of the lead authors and a UC Berkeley postdoctoral fellow. “We wanted to understand how they are able to cope with that.”
“The promise of comparative genomics is that we learn how other organisms deal with conditions that we also are exposed to,” said Nielsen, a member of UC Berkeley’s Center for Theoretical Evolutionary Genomics. “For example, polar bears have adapted genetically to a high fat diet that many people now impose on themselves. If we learn a bit about the genes that allows them to deal with that, perhaps that will give us tools to modulate human physiology down the line.”

The findings accompany the publication of the first assembled genome of the polar bear as the cover story in the May 8 issue of the journal Cell.

Close cousins

The genome analysis comes at a time when the polar bear population worldwide, estimated at between 20,000 and 25,000, is declining and its habitat, Arctic sea ice, is rapidly disappearing. As the northern latitudes warm, the polar bear’s distant cousin, the brown or grizzly bear (Ursus arctos), is moving farther north and occasionally interbreeding with the polar bear (Ursus maritimus) to produce hybrids dubbed pizzlies.

Their ability to interbreed is a result of this very close relationship, Nielsen said, which is one-tenth the evolutionary distance between chimpanzees and humans. Previous estimates of the divergence time between polar bears and brown bears ranged from 600,000 to 5 million years ago.

“It’s really surprising that the divergence time is so short. All the unique adaptations polar bears have to the arctic environment must have evolved in a very short amount of time,” he said. These adaptations include not only a change from brown to white fur and development of a sleeker body, but big physiological and metabolic changes as well. “There has been a lot of debate about it, but I think we really nailed down what the divergence time is between them, and it is surprisingly recent.”

Genetic changes affect fat metabolism

The genome comparison reveals that over several hundred thousand years, natural selection drove major changes in genes related to fat transport in the blood and fatty acid metabolism. One of the most strongly selected genes is APOB, which in mammals encodes the main protein in LDL (low density lipoprotein), known widely as “bad” cholesterol. Changes or mutations in this gene reflect the critical nature of fat in the polar bear diet and the animal’s need to deal with high blood levels of glucose and triglycerides, in particular cholesterol, which would be dangerous in humans. Fat comprises up to half the weight of a polar bear.

Greenlandic polar bear.

“The life of a polar bear revolves around fat,” Lorenzen said. “Nursing cubs rely on milk that can be up to 30 percent fat and adults eat primarily blubber of marine mammal prey. Polar bears have large fat deposits under their skin and, because they essentially live in a polar desert and don’t have access to fresh water for most of the year, rely on metabolic water, which is a byproduct of the breakdown of fat.”

She noted that the evolution of a new metabolism to deal with high dietary fat must have happened very quickly, in just a few hundred thousand years, because we know that polar bears already subsisted on a marine diet 100,000 years ago.

What drove the evolution of polar bears is unclear, though the split from brown bears (dated at 343,000–479,000 years ago) coincides with a particularly warm 50,000-year interglacial period known as Marine Isotope Stage 11. Environmental shifts following climate changes could have encouraged brown bears to extend their range much farther north. When the warm interlude ended and a glacial cold period set in, a pocket of brown bears may have become isolated and forced to adapt rapidly to new conditions.

Samples from all over Arctic

The analysis included blood and tissue samples from 79 Greenlandic polar bears and 10 brown bears from Sweden, Finland, Glacier National Park in Alaska and the Admiralty, Baranof, and Chichagof (ABC) Islands off the Alaskan coast.

Lorenzen (in red) assists Danish researchers in preserving polar bear tissue samples for later

DNA sequencing.

According to Lorenzen, the “key that allowed us to unlock the door of polar bear evolution” was a method devised by UC Berkeley mathematics graduate student Kelley Harris that has been used to estimate human demographic history. The approach, referred to as the identity by state (IBS) tract method, has proved powerful in estimating when ancient human populations diverged, their past population sizes and when and how much they interbred.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Innovative Genomics Initiative Launched
Launch of new genomics initiative draws enthusiastic industry, academic partners.
Friday, February 06, 2015
UC Berkeley, UCSF Launch Innovative Genomics Initiative
Li Ka Shing Foundation provides $10M gift to support the initiative, establishing the Li Ka Shing Center for Genomic Engineering and an affiliated faculty chair at UC Berkeley.
Tuesday, March 18, 2014
Cheap and Easy Technique to Snip DNA Could Revolutionize Gene Therapy
A simple, precise and inexpensive method for cutting DNA to insert genes into human cells could transform genetic medicine.
Tuesday, January 08, 2013
Contaminated Site Yields Wealth of Information on Microbes 10 Feet Under
Sequencing of nearly 150,000 genes from soil samples at a former uranium mill site along the Colorado River in Rifle, Colo.
Thursday, October 04, 2012
In Mice, Having Multiple Partners Breeds More Robust Immune System
UC Berkeley researchers use TACC's Ranger supercomputer to identify genetic differences related to the social lives of mammals.
Wednesday, September 12, 2012
Scientific News
RNAi Screening Trends
Understand current trends and learn which application areas are expected to gain in popularity over the next few years.
Tracking Breast Cancer Before it Grows
A team of scientists led by University of Saskatchewan researcher Saroj Kumar is using cutting-edge Canadian Light Source techniques to screen and treat breast cancer at its earliest changes.
DNA Damage Seen in Patients Undergoing CT Scanning
Along with the burgeoning use of advanced medical imaging tests over the past decade have come rising public health concerns about possible links between low-dose radiation and cancer.
The Mystery of the Instant Noodle Chromosomes
Researchers from the Lomonosov Moscow State University evaluated the benefits of placing the DNA on the principle of spaghetti.
Oxitec ‘Self-Limiting Gene’ Offers Hope for Controlling Invasive Moth
A new pesticide-free and environmentally-friendly way to control insect pests has moved ahead with the publication of results showing that Oxitec diamondback moths (DBM) with a ‘self-limiting gene’ can dramatically reduce populations of DBM.
Web App Helps Researchers Explore Cancer Genetics
Brown University computer scientists have developed a new interactive tool to help researchers and clinicians explore the genetic underpinnings of cancer.
Kiwi Bird Genome Sequenced
The kiwi, national symbol of New Zealand, gives insights into the evolution of nocturnal animals.
Scientists Identify Schizophrenia’s “Rosetta Stone” Gene
Scientists have identified a critical function of what they believe to be schizophrenia’s “Rosetta Stone” gene that could hold the key to decoding the function of all genes involved in the disease.
Yeast Cells Use Signaling Pathway to Modify Their Genomes
Researchers at the Babraham Institute and Cambridge Systems Biology Centre, University of Cambridge have shown that yeast can modify their genomes to take advantage of an excess of calories in the environment and attain optimal growth.
Nanoparticles Can Clean Up Environmental Pollutants
Researchers have found that nanomaterials and UV light can “trap” chemicals for easy removal from soil and water.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!