Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Oxford BioTherapeutics Takes Exclusive Rights to Use Xenomouse® Antibodies and ADC Technology

Published: Friday, May 16, 2014
Last Updated: Friday, May 16, 2014
Bookmark and Share
Company to develop novel antibody-drug conjugate for HER2-negative breast cancer.

Oxford BioTherapeutics has announced that it has obtained the exclusive global rights to certain Xenomouse® antibodies generated by Amgen and to ImmunoGen’s maytansinoid technology for an undisclosed target. The rights were granted under the existing strategic collaboration between Oxford BioTherapeutics and Amgen.

Oxford BioTherapeutics intends to use the antibodies and ADC technology to develop a novel ADC targeting a protein in HER2-negative breast cancer, initially focusing on triple negative breast cancer, and other cancers, where the target is expressed. The target was identified using the Company’s OGAP® discovery technology.

ADCs are a revolutionary new approach to cancer treatment. By harnessing the ability of monoclonal antibodies to bind to specific cell proteins, they deliver potent toxins directly to cancer cells. ADCs target proteins that are highly expressed on cancer cell membranes rather than normal cells thereby achieving greater therapeutic efficacy while sparing normal tissue.

Oxford BioTherapeutics’ pipeline of ADCs is based on novel targets, discovered with its OGAP® technology, combined with proprietary antibody and cancer toxin technologies brought together through a series of collaborations with leading companies in the field. The pipeline incorporates a fully human antibody generated using Amgen’s Xenomouse® technology, combined with one of ImmunoGen’s maytansinoid cancer-killing agents, which have been used in a recently approved ADC targeting HER2-positive breast cancer. This novel antibody-based cancer therapy has completed in vivo proof-of-concept in several solid and liquid tumor models and exploratory toxicology testing, and is currently undergoing preparation for an IND application.

Dr Christian Rohlff, Oxford BioTherapeutics’ CEO, said, “Obtaining these global rights represents a further strategic milestone for Oxford BioTherapeutics, as we complete our transition into a fully-fledged antibody-based cancer therapy business. By combining these antibodies and antibody ‘arming’ technology with our unique cancer target, we have the opportunity to develop an important new treatment for women with triple negative breast cancer who currently have limited therapeutic options.”

Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,200+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Oxford BioTherapeutics Appoints Dr Eugen Leo
Dr. Leo will be responsible for driving the Company’s pipeline of ADCs into clinical development.
Thursday, July 10, 2014
OBT and Menarini Progress Enhanced Antibody for Acute Myeloid Leukemia
First clinical development candidate in $1 billion oncology investment alliance.
Thursday, January 02, 2014
OBT and Boehringer Ingelheim Enter Collaboration
Collaboration to discover novel antibody targets in cancer.
Monday, April 29, 2013
Menarini and OBT Sign Major Strategic Collaboration
Strategic alliance for the clinical development and manufacture of a portfolio of novel antibody-based cancer drugs.
Tuesday, October 30, 2012
Oxford BioTherapeutics Licenses Lonza’s GS Gene Expression System™
Agreement covers the research, development and commercial use of the GS System™ by Oxford BioTherapeutics.
Monday, September 05, 2011
Scientific News
Integrated Omics Analysis
Studying multi-omics promises to give a more holistic picture of the organism and its place in its ecosystem, however despite the complexities involved those within the field are optimistic.
Unravelling the Role of Key Genes and DNA Methylation in Blood Cell Malignancies
Researchers from the University of Nebraska Medical Center have demonstrated the role of Dnmt3a in safeguarding normal haematopoiesis.
Drug Target for Triple-Negative Breast Cancer Found
A team of researchers led by UC San Francisco scientists has identified a new drug target for triple-negative breast cancer.
Wrapping up the Genome
Researchers successfully package complete yeast genome using purified components, yielding new insights into genome mechanisms.
Gene Therapy Going Global with Portable Device
Portable 'gene therapy in a box' could make future cancer and HIV cures affordable in developing countries.
Smartphone Laboratory Detects Cancer
Researchers develop low-cost, portable laboratory on a smartphonecapable of analysing multiple samples simultaneously.
Fighting Cancer with Immune Response
New treatment elicits two-pronged immune response that destroys tumors in mice.
Nanomedicine for Breast Cancer Treatment
Using nanoparticles measuring only billionths of a meter in size, doctors are able to deliver drug molecules directly to the affected tissue.
Zika Virus Infection Alters Human and Viral RNA
Researchers have discovered that Zika infections results in human and viral genetic modification.
Cell Metabolism Linked to Spread of Cancer
Scientists discover macrophage metabolism can be attuned to prevent the spread of cancer.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,200+ scientific videos