Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Interplay between Genetics and Metabolism in Complex Disease Revealed

Published: Friday, May 16, 2014
Last Updated: Friday, May 16, 2014
Bookmark and Share
Metabolomic profiling coupled with genomics data yields new insight into diseases, potential biomarkers and drug treatments

Metabolon announced the publication of a paper entitled “An Atlas of Genetic Influences on Human Blood Metabolites” in Nature Genetics. Co-authored by Metabolon scientists, this paper is the result of a third genome-wide association study (GWAS) that combines genomic data and metabolic profiling to gain comprehensive understanding of the human biological system and presents the most comprehensive metabolomics survey of human metabolism conducted to date.

Building on earlier work published in Nature in 2011, Metabolon, in collaboration with a team of researchers led by Pfizer, King’s College London, Helmholtz Zentrum München, Weill Cornell Medical College in Qatar and Wellcome Trust Sanger Institute, among others, measured over 500 blood metabolites of nearly 8,000 study participants. This effort revealed hundreds of exceptionally strong associations between metabolites and genetic variants. These associations provide a system-wide atlas of the effective activity of human genes and allelic differences, potentially improving disease understanding and providing new opportunities for drug development.

“One of the great conundrums in genomic research, aside from determining gene function, is to determine the biological meaning, if any, of allelic differences,” commented Michael Milburn, Ph.D., Chief Scientific Officer at Metabolon and one of two Metabolon authors to the publication. “Metabolic-allelic associations have the potential to provide a better understanding of gene function and can be enormously helpful in teasing apart genetic differences to improve biological understanding.”

“This study illustrates the power of discovery metabolomics to ‘complete the picture’ in human genomic studies aimed at understanding the complexity of human health,” said John Ryals, Ph.D, President and CEO of Metabolon. “The last decade of genomics research has revealed an even deeper level of complexity than once thought. Advanced metabolomics technology has the potential to bridge complex genetic and proteomic data to provide enhanced insight into the individual phenotype. We are grateful for the efforts of our long-term collaborators, Prof. Tim Spector, Prof. Karsten Suhre and Prof. Gabi Kastenmueller, for their leadership and dedication to this project. It is a tour de force of modern genomic and metabolomic research.”

Metabolon has several ongoing initiatives that utilize its proprietary metabolomics technology to advance genomics-based health research. These include strategic partnerships with Craig Venter’s new genomics initiative, Human Longevity, Inc., and the Global Genomics Group (G3). These collaborations demonstrate increasing awareness among scientific experts about the important role metabolomics can play in other forms of ‘omic’ research.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Study Reveals Interplay between Genetics and Metabolism in Complex Disease
Metabolomic profiling coupled with genomics data yields new insight into diseases, potential biomarkers and drug treatments.
Saturday, May 17, 2014
Metabolon Enters into Collaboration with GSK
Agreement will see Metabolon provide metabolomic profiling services to GlaxoSmithKline.
Wednesday, May 14, 2014
Microbes and Metabolites Fuel an Ambitious Aging Project
Craig Venter’s new company wants to improve human longevity by creating the world’s largest, most comprehensive database of genetic and physiological information.
Wednesday, March 12, 2014
Global Genomics Group and Metabolon to Collaborate
Metabolon will conduct biochemical profiling in single largest prospective pan-omic study.
Thursday, November 14, 2013
Impaired Metabolism in Cystic Fibrosis Lung Epithelial Cells Revealed by Metabolic Analysis
Metabolon announces publication of “Metabolomic Profiling Reveals Biochemical Pathways and Biomarkers Associated with Pathogenesis in Cystic Fibrosis Cells”.
Monday, October 25, 2010
Metabolon Selected for Membership in NCI Research Group
Metabolon to collaborate with other members to discover and develop biomarkers for the early diagnosis of cancers.
Thursday, December 01, 2005
Metabolon Appoints Chief Scientific Officer
Dr. Michael Milburn has been appointed as Chief Scientific Officer.
Wednesday, November 09, 2005
Scientific News
Revolutionary Technologies Developed to Improve Outcomes for Lung Cancer Patients
Breath test to detect lung cancer brings oxygen directly to the wound.
Dementia Linked to Deficient DNA Repair
Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer’s disease.
New Gene Map Reveals Cancer’s Achilles’ Heel
Team of researchers switches off almost 18,000 genes
New Discovery Sheds Light on Disease Risk
Gaps between genes interact to influence the risk of acquiring disease.
Mathematical Model Helps Show How Zebrafish Get Their Stripes
The iconic yellow and blue stripes of zebrafish form dynamically as young fish develop and grow. A mathematical model developed by Brown University researchers helps to show how pigment cells interact to form the pattern.
Epigenome Influenced by Habitat and Lifestyle
Study on Pygmy hunter-gatherer populations and Bantu farmers in Central Africa shows that habitat and lifestyle can impact the epigenome.
Shining Light on Microbial Growth and Death Inside our Guts
Precise measurement of microbial populations in gastrointestinal tracts could be key to identifying novel therapies.
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Biologists Induce Flatworms to Grow Heads and Brains of Other Species
Findings shed light on role of a new kind of epigenetic signaling in evolution, could yield clues for understanding birth defects and regeneration.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos