Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

PsiOxus to Release Study Results of Oncolytic Vaccine Enadenotucirev

Published: Saturday, May 17, 2014
Last Updated: Saturday, May 17, 2014
Bookmark and Share
Phase I studies to be presented at 2014 ASCO annual meeting.

PsiOxus Therapeutics, Ltd. (PsiOxus) has announced that two of its on-going phase I studies of the oncolytic vaccine enadenotucirev (previously known as ColoAd1) will be presented at the 2014 American Society of Clinical Oncology (ASCO) Annual Meeting to be held 30 May to 3 June, 2014 in Chicago, Illinois.

The EVOLVE (EValuating OncoLytic Vaccine Efficacy) trial is a phase I/II trial of intravenous administration of enadenotucirev to patients with epithelial cancers and the MoA (Mechanism of Action) trial is a phase I “window of opportunity” trial evaluating intravenous and intra-tumoural administration of enadenotucirev to patients with colon cancer.

Enadenotucirev is an oncolytic Ad11/Ad3 chimeric group B adenovirus that has previously been shown to selectively destroy metastatic solid tumours at low concentrations in pre-clinical models.

To date, a combined total of 46 cancer patients have been dosed with up to four cycles (12 doses) of enadenotucirev. An independent Data Safety Monitoring Committee has approved the proposed dose to be taken into phase 2 clinical trials for both single cycle and repeat cycle administration. This safety data will be presented at the ASCO meeting.

Intra-tumoural delivery of oncolytic viruses to superficial tumour sites has been shown to be clinically successful in phase III clinical trials, but systemic delivery of viruses to metastatic tumour sites via intravenous delivery has been more elusive.

In the two PsiOxus studies, the ability to selectively deliver the live replicating virus to tumour cells has been examined by a number of techniques including positron emission tomography scans, immunohistochemistry, quantitative polymerase chain reaction assays, and viral plaque assays.

• Dr Emiliano Calvo will present A First in Human Phase I study of enadenotucirev, an oncolytic Ad11/Ad3 chimeric group B adenovirus, administered intravenously in patients with metastatic epithelial tumours (poster board 170) at ASCO on Sunday, June 1 in S Hall A2 from 8:00 a.m. to 11:45 a.m.

• Dr Rocio Garcia Carbonero will present Phase 1 Mechanism of Action Study of Intra-tumoral or Intravenous Administration of enadenotucirev, an Oncolytic Ad11/Ad3 Chimeric group B Adenovirus in Colon Cancer Patients Undergoing Resection of Primary Tumour (poster board 178B) at ASCO on Sunday, June 1 in S Hall A2 from 8:00 a.m. to 11:45 a.m.

Dr John Beadle, CEO of PsiOxus, commented: “We are looking forward to the presentation of these clinical study results as we assess the safety profile of enadenotucirev as well as intravenous delivery of this oncolytic vaccine to cancer cells in patients. We remain on track to initiate phase II study later this year.”

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Myotec Merges with Hybrid Biosystems to Form PsiOxus Therapeutics
Imperial Innovations Group plc, a leading technology commercialisation and investment group, announces the merger of its portfolio company Myotec Therapeutics Ltd. (Myotec) with Hybrid Biosystems Ltd. (Hybrid) to form PsiOxus Therapeutics.
Wednesday, December 15, 2010
Scientific News
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Biologists Induce Flatworms to Grow Heads and Brains of Other Species
Findings shed light on role of a new kind of epigenetic signaling in evolution, could yield clues for understanding birth defects and regeneration.
Turning up the Tap on Microbes Leads to Better Protein Patenting
Mining millions of proteins could become faster and easier with a new technique that may also transform the enzyme-catalyst industry, according to University of California, Davis, researchers.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Tardigrade's Are DNA Master Thieves
Tardigrades, nearly microscopic animals that can survive the harshest of environments, including outer space, hold the record for the animal that has the most foreign DNA.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Farming’s in Their DNA
Ancient genomes reveal natural selection in action.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos