Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Sigma-Aldrich Expands Position in Whole Genome Amplification

Published: Monday, February 20, 2006
Last Updated: Monday, February 20, 2006
Bookmark and Share
Sigma-Aldrich enters licensing agreement to offer GenomePlex® Whole Genome Amplification kits to service providers.

Sigma-Aldrich has announced a licensing agreement with Rubicon Genomics that allows Sigma to offer GenomePlex® Whole Genome Amplification (WGA) kits to service providers.

Under this agreement, Sigma-Aldrich may sell GenomePlex kits to companies offering Whole Genome Amplification Services, thus expanding the service market to archived samples, FFPE and single cells.

Rubicon Genomics will retain all rights to WGA for molecular diagnostics, and will continue its existing service business.

"This licensing agreement enables Sigma-Aldrich to partner with service providers that offer genetic processing capabilities and expertise," said Keith Jolliff, Director of Strategic Marketing at Sigma-Aldrich.

"Market Research shows that thirty percent of customers are currently using service companies for WGA. However, service providers have been limited in their ability to amplify DNA from damaged or degraded sources, such as FFPE or archived samples, and from single cells."

"This agreement allows Sigma-Aldrich to more broadly share our enhancements of the GenomePlex technology to enable service providers to more effectively meet the needs of researchers."

In 2004 Sigma-Aldrich announced an exclusive licensing agreement with Rubicon Genomics to further develop and commercialize the GenomePlex WGA technology.

At that time, Rubicon Genomics retained all rights to WGA for molecular diagnostics and services. Sigma-Aldrich's success with the GenomePlex technology has led to the development of several kits that offer accurate amplification.

The latest addition to the product family is the GenomePlex Single Cell WGA Kit, which is designed to support whole genome amplification from a single cell and results in a million-fold amplification of genomic DNA.

GenomePlex is a proprietary amplification method based on random fragmentation of the genome into a series of overlapping, short templates.

The resulting shorter DNA strands are efficiently primed and amplified to generate a library of DNA fragments with defined 3' and 5' termini, or the OmniPlex® library.

This library is replicated using a linear, isothermal amplification in the initial stages, followed by a limited round of geometric (PCR) amplifications.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Sigma Life Science Collaborates with Cofactor Genomics to Develop Publically Available Rat Genome Database
Sigma Life Science announces that its SAGE Labs initiative has partnered with Cofactor Genomics in an effort to sequence genomes for six of the most widely used strains of rat. Cofactor Genomics plans to generate and analyze sequence data using next generation sequencing systems, while SAGE Labs plans to provide the samples and to host a new, free public database at in late 2011.
Thursday, February 03, 2011
Sigma® Life Science Awarded Silver in Top Ten Innovations 2010
Company’s CompoZr® cell lines ranked second as The Scientist magazine unveils this year’s best life science innovations.
Monday, December 06, 2010
Sigma® Life Science Enters Genetically Modified Cell Market
Sigma Life Science launches range of engineered cell lines exploiting CompoZr® zinc finger nuclease technology.
Monday, September 06, 2010
Sigma® Life Science and Switchgear Genomics to Co-Develop Simplified Novel MicroRNA Target Validation System
SwitchGear Genomics and Sigma’s lentiviral technology combined to simplify miRNA target validation, enabling researchers to investigate gene regulation.
Tuesday, August 10, 2010
Sigma-Proligo Expands into Genopole® d'Evry Biopark
Sigma-Proligo provides researchers with high-quality oligonucleotides due to a high throughput synthesis platform.
Friday, October 20, 2006
Sigma-Aldrich Announces Service Provider for WGA Technology
Sigma announces MOgene as its first service provider of the GenomePlex® Whole Genome Amplification technology.
Wednesday, May 31, 2006
Sigma-Aldrich Sponsors Full-Text Article on High Content Viral Library Screens
The authors reported the creation of a lentiviral shRNA library to knock down genes for genome-wide screening.
Thursday, April 27, 2006
Sigma-Aldrich Names Jai Nagarkatti as Chief Executive Officer
The appointment will be effective on January 1, 2006.
Wednesday, November 09, 2005
Sigma Granted Patent for REDTaq™ DNA Polymerase Product Line
REDTaq™ products are a blend of various DNA polymerases combined with an inert red dye that allows quick visual confirmation of enzyme addition and reaction homogeneity.
Friday, September 16, 2005
Sigma-Aldrich Launches Online STAIN EXPERT™ Application
A Flash Platform is designed to guide customers through a wide range of staining procedures while reducing the complexity of multi-step processes.
Thursday, September 08, 2005
Scientific News
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Tardigrade's Are DNA Master Thieves
Tardigrades, nearly microscopic animals that can survive the harshest of environments, including outer space, hold the record for the animal that has the most foreign DNA.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Farming’s in Their DNA
Ancient genomes reveal natural selection in action.
GMO Food Animals Should be Judged by Product, Not Process
In a world with a burgeoning demand for meat, milk and eggs, regulatory policies around the use of biotechnologies in agriculture need to be based on the safety and attributes of those foods rather than on the methods used to produce them, says a UC Davis animal scientist.
Enzyme Critical to Maintaining Telomere Length Discovered
New method expected to speed understanding of short telomere diseases and cancer.
Gene Drive Reversibility Introduces New Layer of Biosafety
Ability to introduce or reverse the spread of genetic traits through populations could one day improve pest management and disease control.
RNA-Based Drugs Give More Control Over Gene Editing
CRISPR/Cas9 gene editing technique can be transiently activated and inactivated using RNA-based drugs, giving researchers more precise control in correcting and inactivating genes.
University of Glasgow Researchers Make An Impact in 60 Seconds
Early-career researchers were invited to submit an engaging, dynamic and compelling 60 second video illuminating an aspect of their research.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos