Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

"Land of the Ever-Young" Gene Reprogrammes Cells

Published: Monday, June 19, 2006
Last Updated: Thursday, June 22, 2006
Bookmark and Share
A team of scientists at the Institute for Stem Cell Research investigated the switching of adult cell types into embryonic stem cells after cell fusion.

University of Edinburgh scientists have discovered that the "ever-young" gene Nanog can cause adult cells to switch back to an embryonic state.

The finding, to be published in the journal Nature, is the first to show that a specific gene affects the reprogramming of a mature cell type into a native state.

The Edinburgh team believe this is a promising step towards understanding how to promote regeneration of damaged tissues and organs using a person's own cells.

The team of scientists, lead by Austin Smith at the Institute for Stem Cell Research, investigated the switching of adult cell types into embryonic stem cells after cell fusion.

Fusion is the combination of two cells to form a single hybrid cell. Like nuclear transfer, the cloning process used to create Dolly the sheep, cell fusion can reprogramme the genetic information in a specialised cell to a native embryonic state. But this occurs very rarely.

Says Austin Smith, "We set out to identify genes that could make reprogramming more efficient -our first candidate was Nanog because of its special role in formation of the early embryo and embryonic stem cells."

The Edinburgh scientists fused mouse embryonic stem cells with brain stem cells, a type of adult stem cell.

They found that the addition of Nanog resulted in a massive increase in the numbers of hybrid cells, all of which behaved like embryonic stem cells.

Most importantly the hybrid cells showed the capacity to make many different cell types, such as heart and gut.

"This means that the genetic programme of the brain cells has been erased and replaced by the unspecialised programme of an early embryo cell," says Jose Silva, first author of this study.

Jose adds, "The effect of Nanog is remarkable. All of the hybrid cells become fully converted to embryonic stem cells. If we can figure out how Nanog does this, it may become possible to switch cell types without fusion or cloning."

However, the Edinburgh team must also identify at least one other key gene. "Nanog has great power," says Austin Smith, "but it does not work in isolation, only in partnership with other genes present in embryonic stem cells."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,900+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Only Half of a Chromosome is DNA
Study discovers that DNA makes up far less of the material inside chromosomes than was previously thought.
Tuesday, November 22, 2016
Coffee Consumption Linked to Genes
Researchers have identified a gene that influences coffee consumption. The gene is thought to relate to caffeine breakdown.
Friday, August 26, 2016
Effects of Chemotherapy on Developing Ovaries in Female Fetuses
Researchers at University of Edinburgh have shown that etoposide can damage the development of the ovaries while a fetus is in the womb.
Friday, August 12, 2016
Salt Gene Could Help Cut Heart Disease
Scientists from the University of Edinburgh find that removal of a gene linked with high blood pressure causes a strong appetite for salt.
Wednesday, March 30, 2016
Risk of Brain Injury is Genetic
Link between injury to the developing brain and common variation in genes identified.
Tuesday, May 20, 2014
University of Edinburgh Purchases Arrayjet Microarray Spotter
The spotter increases throughput capacity and performance essential to meet the increasing demand for high quality microarrays.
Tuesday, June 20, 2006
Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Accelerating the Detection of Foodborne Bacterial Outbreaks
The speed of diagnosis of foodborne bacterial outbreaks could be improved by a new technique developed by researchers at the Georgia Institute of Technology.
Top 10 Life Science Innovations of 2016
2016 has seen the release of some truly innovative products. To help you digest these developments, The Scientist have listed their top picks for the year.
Scientists Identify Unique Genomic Features in Testicular Cancer
The findings may shed light on factors in other cancers that influence their sensitivity to chemotherapy.
Secret Phenotypes: Disease Devils in Invisible Details
Algorithmic deep phenotyping exposes masses of hidden traits and possible subtle genetic connections relevant to unseen influences on disease.
Cracking the Code of a Deadly Virus
Researchers have exploited weaknesses in VEEV's genetic code, creating a far less deadly variant.
Hunting the Missing Link Between Genetics and the Environment
The International Phenome Centre Network (IPCN) works to transform healthcare through phenomics - the dynamic interactions between our genes and our environment.
Repurposing Genes for Brain Development
Mammalian bone gene may be repurposed to promote cognition in humans.
Enhancing CRISPR to Explore Further
Researchers have developed sOPTiKO, a more efficient and controllable CRISPR genome editing platform.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!