Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

"Land of the Ever-Young" Gene Reprogrammes Cells

Published: Monday, June 19, 2006
Last Updated: Thursday, June 22, 2006
Bookmark and Share
A team of scientists at the Institute for Stem Cell Research investigated the switching of adult cell types into embryonic stem cells after cell fusion.

University of Edinburgh scientists have discovered that the "ever-young" gene Nanog can cause adult cells to switch back to an embryonic state.

The finding, to be published in the journal Nature, is the first to show that a specific gene affects the reprogramming of a mature cell type into a native state.

The Edinburgh team believe this is a promising step towards understanding how to promote regeneration of damaged tissues and organs using a person's own cells.

The team of scientists, lead by Austin Smith at the Institute for Stem Cell Research, investigated the switching of adult cell types into embryonic stem cells after cell fusion.

Fusion is the combination of two cells to form a single hybrid cell. Like nuclear transfer, the cloning process used to create Dolly the sheep, cell fusion can reprogramme the genetic information in a specialised cell to a native embryonic state. But this occurs very rarely.

Says Austin Smith, "We set out to identify genes that could make reprogramming more efficient -our first candidate was Nanog because of its special role in formation of the early embryo and embryonic stem cells."

The Edinburgh scientists fused mouse embryonic stem cells with brain stem cells, a type of adult stem cell.

They found that the addition of Nanog resulted in a massive increase in the numbers of hybrid cells, all of which behaved like embryonic stem cells.

Most importantly the hybrid cells showed the capacity to make many different cell types, such as heart and gut.

"This means that the genetic programme of the brain cells has been erased and replaced by the unspecialised programme of an early embryo cell," says Jose Silva, first author of this study.

Jose adds, "The effect of Nanog is remarkable. All of the hybrid cells become fully converted to embryonic stem cells. If we can figure out how Nanog does this, it may become possible to switch cell types without fusion or cloning."

However, the Edinburgh team must also identify at least one other key gene. "Nanog has great power," says Austin Smith, "but it does not work in isolation, only in partnership with other genes present in embryonic stem cells."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Salt Gene Could Help Cut Heart Disease
Scientists from the University of Edinburgh find that removal of a gene linked with high blood pressure causes a strong appetite for salt.
Wednesday, March 30, 2016
Risk of Brain Injury is Genetic
Link between injury to the developing brain and common variation in genes identified.
Tuesday, May 20, 2014
University of Edinburgh Purchases Arrayjet Microarray Spotter
The spotter increases throughput capacity and performance essential to meet the increasing demand for high quality microarrays.
Tuesday, June 20, 2006
Scientific News
World’s Largest Coral Gene Database
‘Genetic toolkit’ will help shed light on which species survive climate change.
Early Genetic Changes in Premalignant Colorectal Tissue Identified
Findings point to drivers of early cancer development, targets for cancer prevention therapies.
Scientists Find Evidence That Cancer Can Arise Changes
Researchers at Rockefeller University have found a mutation that affects the proteins that package DNA without changing the DNA itself can cause a rare form of cancer.
Modified Microalgae Converts Sunlight into Valuable Medicine
A special type of microalgae can soon produce valuable chemicals such as cancer treatment drugs and much more just by harnessing energy from the sun.
Breakthrough Approach to Breast Cancer Treatment
Scripps scientists have designed a drug candidate that decreases growth of breast cancer cells.
Loss Of Y Chromosome Increases Risk Of Alzheimer’s
Men with blood cells that do not carry the Y chromosome are at greater risk of being diagnosed with Alzheimer’s disease. This is in addition to an increased risk of death from other causes, including many cancers. These new findings by researchers at Uppsala University could lead to a simple test to identify those at risk of developing Alzheimer’s disease.
A Guide to CRISPR Gene Activation
A comparison of synthetic gene-activating Cas9 proteins can help guide research and development of therapeutic approaches.
Gene That Lowers Heart Attack Risk Identified
Individuals with a rare twelve-letter deletion from a gene on chromosome 17 have significantly reduced non-HDL cholesterol levels and a 35% lower than average risk of heart disease.
Testing Non-Breast/Ovarian Cancer Genes
Researchers have found that expanding gene panel beyond breast/ovarian cancer genes in these patients does not add any clinical benefit. Instead, testing has produced more questions than answers.
Myeloid-Derived Suppressor Cells Play Role in Tumor Growth
Researchers at Baylor College of Medicine have reported a new mechanism that helps cancer cells engage myeloid-derived suppressor cells.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!