Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Princeton University Selects Thermo Scientific MALDI LTQ Orbitrap to Enable Proteomics and Genomics Research on Viruses

Published: Friday, August 22, 2008
Last Updated: Friday, August 22, 2008
Bookmark and Share
The University is utilizing the MALDI LTQ Orbitrap XL™ mass spectrometer for research on virus-host protein interactions in the laboratory of Ileana Cristea.

Thermo Fisher Scientific Inc. has announced that Princeton University is utilizing the MALDI LTQ Orbitrap XL™ mass spectrometer for research on virus-host protein interactions in the laboratory of Ileana Cristea, Ph.D.

Dr. Cristea’s work on chromatin and its modulation by viruses promises to further scientists’ understanding about how viruses manipulate their host to their advantage.

The laboratory employs a multidisciplinary approach, incorporating methodologies from modern proteomics, biochemistry, molecular biology and virology. The research, while preliminary, holds implications for improved therapies for the treatment of viral infections, from the common cold to HIV.

Because the samples required for the studies are difficult to obtain and the elements of interest are frequently present at very low levels, Dr. Cristea began exploring the benefits of combining MALDI with mass spectrometry (MS) instrumentation.

Interested in novel MS developments, she believed there would be significant benefit with the integration of the Thermo Scientific LTQ Orbitrap with a MALDI interface.

“I am quite impressed that I have in my laboratory the first configuration of its kind in the MALDI LTQ Orbitrap XL,” said Dr. Cristea, Assistant Professor with Princeton University’s Department of Molecular Biology.

“Its performance has already proven to be terrific. This instrument combines the robustness and high throughput capabilities of MALDI with the sensitivity of the linear trap and the high mass accuracy and resolution of the Orbitrap. The MALDI LTQ Orbitrap XL is perfectly suited for characterizing protein complexes. After the initial MS and MS/MS analyses and identifications, the samples can be preserved on the MALDI target to pursue new interesting directions revealed by the first analyses,” Dr. Cristea continued.

The MALDI option is available for both the LTQ Orbitrap Discovery and LTQ Orbitrap XL platforms. The addition of the new MALDI source on the LTQ Orbitrap is suited for proteomics and metabolism applications. Other applications include high-throughput in-gel digest, de novo sequencing, quantitation based on isobaric labeling strategies (TMT® Tags, iTRAQ™), tissue imaging and small molecule analysis.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,400+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Thermo Scientific Signs Agreement with Novartis, Pfizer
Universal test designed for non-small cell lung cancer supports multiple drug development programs.
Thursday, November 26, 2015
Ebola Sequencing Data Released to Global Research Community Online
To curb further spread of Ebola in Sierra Leone, a team of scientists that is part of an international, multi-organizational effort has released their first dataset of the virus’ genetic structure online.
Wednesday, June 03, 2015
Thermo's NGS Platform Selected for Nationwide Clinical Research Program
National Cancer Institute-MATCH trial to sequence thousands of tumor samples using Ion Torrent targeted sequencing technology.
Monday, June 01, 2015
Thermo Fisher Q3 Revenues up 31 Percent
Thermo Fisher announced that revenues grew 31% to $4.17 billion for the third quarter ended September 27, 2014.
Thursday, October 23, 2014
Thermo Scientific Announces Listing of the Ion PGM Dx System
Company has completed the listing with the U.S. FDA as class II medical device.
Saturday, September 20, 2014
ATCC, CDC and Thermo Partner on Public Health RT-PCR Assay
New technology supports HIV-1 drug resistance surveillance in resource-limited countries.
Wednesday, June 25, 2014
Thermo Reports 22% Revenue Rise in Q1 2014
Results include the addition of Life Technologies as of February 4, 2014, and exclude the previously announced related divestitures as of March 22, 2014.
Wednesday, April 23, 2014
Thermo Completes Life Tech Acquisition
The completion of the transaction follows the receipt of all required regulatory approvals.
Tuesday, February 04, 2014
Thermo Reports 6% Q4 Revenue Growth
Thermo Fisher Scientific Inc. reported its financial results for the fourth quarter and full year ended December 31, 2013.
Friday, January 31, 2014
Thermo Receives EC Clearance for Life Tech Acquisition
Thermo Fisher Scientific announced that it has received approval from the European Commission (EC) for its pending acquisition of Life Technologies Corporation.
Tuesday, November 26, 2013
Thermo Fisher Scientific Opens Its First Dry Powder Media Facility in APAC Region
Singapore facility delivers manufacturing redundancy and increases supply assurance for global biologic drug discovery and production.
Tuesday, August 06, 2013
Record Revenues for Thermo Fisher Scientific
Revenue for the quarter grew 6% to $3.26 billion in 2012, versus $3.09 billion in 2011.
Thursday, January 31, 2013
Thermo Fisher Scientific Announces Application Deadlines for Life Sciences Scholarships
Thermo Scientific Pierce Scholarship Winter/Spring semester applications due December 14, 2012.
Wednesday, November 14, 2012
Thermo Fisher Scientific Expands Scientific Advisory Board
Dr. Klaus Lindpaintner to lead strategic development of innovative analytical technologies.
Thursday, November 08, 2012
Thermo Fisher Scientific Improves Cancer Diagnostics for West of Scotland Regional Cytogenetics Service
Thermo Scientific products improve automation and efficiency for cytogenetics department.
Tuesday, February 23, 2010
Scientific News
Probing How CRISPR-Cas9 Works
New study in Journal of Cell Biology examines DNA targeting dynamics in live cells.
Diagnosing Tumors of Unknown Origin
EPICUP® test is a tool that helps to identify up to 87% of cancers of unknown origin (COD).
Genome Editing Without Cleaving DNA
A team involving Kobe University researchers has succeeded in developing ‘Target-AID’, a genome editing technique that does not cleave the DNA.
New Possibilities Tumor Research
Grazer researchers say gene activity of the tumor from the analysis of circulating DNA in blood ahead.
Controlling Genome Editing with Light
New technique offers precise manipulation of when and where genes are targeted.
Breast Cancer Cells Found To Switch Molecular Characteristics
Spontaneous interconversion between HER2-positive and HER2-negative states could contribute to progression, treatment resistance in breast cancer.
Some Breast Cancer Patients With Low Genetic Risk Could Skip Chemotherapy
Genetic test can help predict survival and guide treatment options.
Lose Weight, Escape the Eight: Weight-Based Cancer Risk
IARC has identified eight additional cancer sites linked to overweight and obesity.
Coffee Consumption Linked to Genes
Researchers have identified a gene that influences coffee consumption. The gene is thought to relate to caffeine breakdown.
Emerging Model of Cancer
Cancer acts cooperatively, making individual decisions but acting in unison; this insight is being used to create a computer model of cancer.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!