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Novel Nucleosomics Serum Biomarkers for the Detection of Colorectal Cancer
S Holdenrieder, Y Dharuman, J Standop, M Herzog, N Trimpop, K Hettwer, K Simon, Steffen Uhlig and Jake Micallef

As colorectal cancers are often detected at late tumor stages when prognosis of the patients is poor, powerful blood-based biomarkers are needed for earlier detection. In recent years it has become clear that epigenetic changes to chromatin and its constituent nucleosomes are associated with carcinogenesis and elevated levels of nucleosomes are present in the blood of cancer patients.

Fingerprinting analytical strategy used for authentication of honey
Oana Romina DINCAa,b, Roxana Elena IONETEa*, Raluca POPESCUa, Radu TAMAIANa, Diana COSTINELa, Gabriel Lucian RADUb

The goal of the current study is mainly to establish potential origin markers, and not to build a model for prediction. This research provides a database for comparison of honey samples from Romania with other honey samples from the world. Data on d13C, d18O and d2H of honey measured by IRMS together with the stable isotopes (deuterium by SNIF-NMR and carbon 13 - IRMS) in ethanol from fermented honeys were reported.

A novel DNA amplification method based on silicon microring resonator for rapid detection of genetic alteration in the point-of care (POC) field of cancers

Nucleic acid testing plays a critical role in molecular diagnosis[1-2]. Due to the low amounts of DNA obtained in clinical samples, the amplification of DNA is an essential step in most NAT methods [3].

Hypothesis of an Existence of a Reverse Pathway (Rp) which Passes Genetic Information from Polypeptide Antigens to Ig Genes in B-Lymphocytes
Victor J. Alexander

Results of this research will bring new more effective treatment methods of many immune related diseases, including cancer.

Oral Health Management of a Patient with 47 XYY Syndrome
Dr Altaf H Shah, Prof. Amjad H Wyne and Prof. Rita Khounganian

The 47XYY syndrome is an aneuploidy of sex chromosomes, where a human male receives an extra Y-chromosome making a total of 47 instead of the usual 46.

The Challenges of Relieving Cancer Pain: A Literature Review
Rayna Patel

This study aims to explore the discrepancy between the increasing array of treatments for cancer pain, as well as the evidence that it can be managed effectively in the majority of cases, and its persisting prevalence.

Evaluation of 2012 Bowel Cancer Awareness and Early Diagnosis Campaign at a District General Hospital
M Alkhusheh, H Asalieh, N Smith

Following the regional Be Clear on Cancer campaign, the Department of Health launched a national bowel cancer awareness campaign from 30 January 2012. The campaign ran until the end of March.

Identification and Characterization of Strain Specific Drug Target by Subtractive Genome Analysis of Methicillin Resistance Staphylococcus aureus
Kiran Saeed and Reaz Uddin

This study aimed to identify and characterize strain specific essential protein targets, which will eventually help in the identification of druggable proteins in two strains of MRSA by using different Bioinformatic tools and databases. We adopting a subtractive genome approach within the domain of Computational Biology.

Kidney Genes Expression in Hypertensive ISIAH Rats
Tatyana Pylnik

The present study was performed to detect the key genes involved in the hypertensive phenotype manifestation in the ISIAH rats with inherited stress-induced arterial hypertension.

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Scientific News
Common Cell Transformed into Master Heart Cell
By genetically reprogramming the most common type of cell in mammalian connective tissue, researchers at the University of Wisconsin—Madison have generated master heart cells — primitive progenitors that form the developing heart.
Genetic Mutation that Prevents Diabetes Complications
The most significant complications of diabetes include diabetic retinal disease, or retinopathy, and diabetic kidney disease, or nephropathy. Both involve damaged capillaries.
Could the Food we Eat Affect Our Genes?
Almost all of our genes may be influenced by the food we eat, according to new research.
Neanderthal DNA Influences Human Disease Risk
Large-scale, evolutionary analysis compares genetic data alongside electronic health records.
Improving Regenerative Medicine
Lab-created stem cells may lack key characteristics, UCLA research finds.
Tick Genome Reveals Secrets of a Successful Bloodsucker
NIH has announced that decipher the genome of the blacklegged tick which could lead to new tick control methods.
"Dark Side" of the Transcriptome
New approach to quantifying gene "read-outs" reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases.
Individuals' Medical Histories Predicted by their Noncoding Genomes
Researchers have found that analyzing mutations in regions of the genome that control genes can predict medical conditions such as hypertension, narcolepsy and heart problems.
New Source of Mutations in Cancer
Recently, a new mutation signature found in cancer cells was suspected to have been created by a family of enzymes found in human cells called the APOBEC3 family.
Advancing Synthetic Biology
Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.
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