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Integrated In Silico Analysis of NGS Prostate Cancer Data via High-Resolution RNA-Seq Analysis
Sandeep Sanga , Antoaneta Vladimirova, Aubree Hoover

The goal: To get novel insights into the mechanisms of prostate adenocarcinoma by leveraging next generation sequencing (NGS) data, particularly human transcriptome data, through in silico data analysis and interpretation by Ingenuity’s IPA® software. CLC Genomics Workbench and CLC Genomics Server helped us assess short read RNA-Seq data.

DNA Methylation as a Marker of the Intra Uterine Environment
Carolyn Banister, Devin Koestler, Matthew A. Maccani, E. Andres Houseman, James F. Padbury and Carmen J. Marsit

The placenta functions not only as a conduit for nutrient and waste exchange between mother and fetus, but also as a regulator of the intrauterine environment. Recent work has identified changes in the expression of candidate genes, often through epigeneticalteration, which alter the placenta’s function and impact fetal growth.

Prognostic Factors for Refeeding Syndrome in Head and Neck Cancer Patients
James Hare, Rachel Skelly, Samit Ghosh, Terry Jones

Head and neck cancer sufferers are inherently at risk of refeeding syndrome, which had a prevalence of 9.5% in our series. Our results suggest that site of tumour (but not tumour or nodal staging) is a prognostic indicator for developing refeeding syndrome.

SuperNatural: A Database of Available Natural Compounds
Melanie Füllbeck, Mathias Dunkel and Robert Preissner

The majority of marketed drugs are natural compounds or derivatives thereof. The compounds availability is often unclear. Therefore we have compiled a database of ~50,000 natural compounds. Starting point for in silico screenings are about 2,500 well-known, classified natural compounds or imported molecules. Possible medical applications can be detected and about three million conformers computed to account for the flexibility during usage of the 3D-superposition algorithm.

Nucleic Acid Reagents and Experimental Results in the NCBI Probe Database
Svetlana Iazvovskaia, Ilene Karsch Mizrachi, Kirill Rotmistrovsky, and Savani Tatake

Five years ago, the NCBI Probe database (ProbeDB) was established to provide a centralized archive of molecular probes used in biomedical applications. Currently ProbeDB contains around 10 million probes of 65 types including gene silencing agents, in situ hybridization probes, and probes for variation analysis and genome mapping. Presently, ProbeDB is the largest and most extensive database of this type available in public domain.

Development of a Test Battery for Epigenetic Non-genotoxic Carcinogens
Haroon Rashid

The main objective of this sudy is to obtain an increased insight into the mechanisms of action of epigenetic carcinogens. Although the expected number of non-genotoxic carcinogens among newly registered compounds is unknown, there is a growing concern that when numbers of 2-year cancer bioassays are significantly reduced, non-genotoxic carcinogens may go undetected. Therefore there is a need for the development of alternative methods for their detection.

Digital Volumetric Imaging of Angiogenesis in Tissue Engineered Constructs
Marc M. Takeno, Kip D. Hauch

Accurate identification of functional vasculature is of critical importance in evaluating construct integration. Digital volumetric imaging (DVI) is an automated serial sectioning and microscopic imaging technique that can bridge the resolution gap between micro-computed tomography and conventional histology. We use DVI to study in vivo vascularization of tissue engineering constructs in a variety of settings.

Optical Imaging of Cerebellar Dysfunction in SCA1 Mice
Nathan Jorgensen, Gang Chen, Wangcai Gao, Timothy Ebner, Harry Orr

Spinocerebellar ataxia type 1(SCA1) is an inherited cerebellar neurodegenerative disorder caused by a polyglutamine tract expansion in the ataxin-1 protein.

Training rural Guatemalan midwives to assess newborn gestational age
KC Bly, Christina Ha, Teresa Keirns, Amy Levi, Lisa Thompson

Half of rural Guatemala's population is indigenous; most births are attended at home by traditional midwives. Perinatal mortality is 2nd highest in Latin America. We administered a survey and implemented a training aimed at reducing perinatal mortality.

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Showing Results 121 - 130 of 270
Scientific News
Diagnosing Cancer with Help from Bacteria
Engineered probiotics can detect tumors in the liver.
Sperm Motility Gene Linked to Height
A team of scientists believe they have identified the association between human height and a specific gene found in sperm.
Tumor Microenvironment Impacts Cancer Subtype Progression
Scientists report that two different mouse models of breast cancer progressed differently based on characteristics of the tumor microenvironment, which is the area of tissue in which the tumor is embedded.
Scientists Win Grant to Expand Study of Innovative Obesity Therapy
The grant is to advance an innovative approach to the treatment of obesity, a serious health problem that affects more than one-third of all Americans.
‘Rosetta Stone’ for Prostate Cancer Mutations
Scientists have produced a comprehensive genetic map of the mutations in prostate cancer that have spread across the body.
From Worker to Queen at the Drop of a Gene
Biologists have found that the hierarchical fate of one of nature's most important pollinators comes down to which genes are "turned on or off".
Researchers use Nanoparticle Tracking Analysis to Study Extracellular Vesicles
Scientists are working to find a way deliver a specific microRNA species capable of retarding the growth of tumor cells.
Two New and Very Large Classes of RNAs Linked to a Cancer Biomarker Identified
Study shows two new classes of RNAs could play a role in progression of prostate cancer.
Master Gene Regulator Could Be New Target For Schizophrenia Treatment
Researchers at MIT’s Picower Institute for Learning and Memory have identified a master genetic regulator that could account for faulty brain functions that contribute to schizophrenia.
DNA Mutations get Harder to Hide
Rice University researchers have developed a method to detect rare DNA mutations with an approach hundreds of times more powerful than current methods.
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