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TFAP2B is Associated with WNT/ß-catenin Pathway in Luminal Breast Cancer
Benjamin Otto1,2, Kristin Klätschke2, Thomas Streichert3, Christoph Wagener2, Genrich Tolstonog4

Here we aimed to investigate which molecular mechanisms are associated with TFAP2B expression in luminal breast cancer.

Transcription Factors to Classify Tumor Types and Subtypes
Benjamin Otto 1,2, Kristin Klätschke 2, Thomas Streichert 3, Christoph Wagener 2, Genrich Tolstonog 4

Here we introduce the use of the unsupervised approach to identify transcription factors (TFs) that are specific for different tumor types.

Expression Profiling of Circulating Tumor Cells: a Prognostic and Predictive Biomarker in Cancer.
Mikael Kubista, Robert Sjöback,Marie Jindrichova, Eva Rohlova, Vendula Novosadová, Siegfrid Hauch, Bahriye Aktas, Mitra Tewes,Maren Bredemeier, and SabineKasimir-Bauer

We show non-responders to treatment among breast cancer patients can be identified by expression profiling of circulating tumor cells

LC-MS/MS METHOD FOR THE QUANTIFICATION OF PITOFENONE IN HUMAN PLASMA
B.M. Gurupadayya, S. Sharfuddin and R.S. Chandan

We developed LCMS/MS bioanalytical method for quantitative estimation of Pitofenone HCl in plasma is simple, sensitive, accurate, precise, and selective. Percentage recovery shows that the method is free from interference of matrix. The analytical method presented here has proved to be useful for investigation of the characteristics of Pitofenone in human plasma in pharmacokinetic and pharmacogenetic studies.

Experimental Evolution in Diatoms - Thermal longterm acclimation in two model diatom species
Katrin Schmidt1, Sinéad Collins2, Thomas Mock1

Experimental Evolution in two model Diatoms

Antioxidant and Free Radicals Scavenging Activity of Biomolecules: Hydroxamic Acids
Bharati Verma and Rama Pande

In the present poster attention is focused towards the investigation of antioxidant and free radicals scavenging activity of N-aryl substituted hydroxamic acids by DPPH method which is based on the reduction of alcoholic DPPH solutions in presence of a hydrogen donating antioxidant, hydroxamic acids.

"In-vitro studies on hydroxamic acid- CT DNA binding"
Rubi Khilari

In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.

Efficacy of Gene Therapy in Restoring Vision in Leber's Congenital Amaurosis
Elizabeth O'Donnell

The research reviews current knowledge of the genetic causes of Leber's congenital amaurosis (LCA) and the development of a gene therapy intervention for LCA. The efficacy as well as the limitations of this form of treatment are evaluated in detail and recommendations are made for the future directions of gene therapy for Leber's congenital amaurosis.

METHOD DEVELOPMENT FOR THE SIMULTANEOUS DETERMINATION OF METHYLMERCURY AND INORGANIC MERCURY IN SEAFOOD
Sergio Carneado, Ariane V. Zmozinski, Carmen Ibáñez-Palomino, Àngels Sahuquillo, José Fermín López-Sánchez, Márcia M. da Silva

This work reports the method development for the simultaneous determination of methylmercury (MeHg+) and inorganic mercury (iHg) species in seafood. The study focused on the extraction and quantification of MeHg+ by liquid chromatography coupled to on-line UV irradiation and cold vapour atomic fluorescence spectroscopy (LC-UV-HG-AFS), using HCl 4 mol L-1 as extractant agent.

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Showing Results 21 - 30 of 286
Scientific News
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UMMS sequences hookworm genome; may lead to new treatments for tropical disease.
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New evidence shows wheat reached Britain 2,000 years before the arrival of wheat farming.
A Gene For Brain Size - Only Found In Humans
Following the traces of evolution: Max Planck Researchers find a key to the reproduction of brain stem cells.
New Nanodevice Defeats Drug Resistance
Tiny particles embedded in gel can turn off drug-resistance genes, then release cancer drugs.
More DNA & Extra Copies of Disease Gene in Alzheimer’s Brain Cells
Scientists at The Scripps Research Institute (TSRI) have found diverse genomic changes in single neurons from the brains of Alzheimer’s patients, pointing to an unexpected factor that may underpin the most common form of the disease.
Epigenetic Study Highlights Drug Targets for Allergies and Asthma
Scientists have discovered over 30 new genes that predispose people to allergies and asthma, some of which could be targets for new drugs.
Partek Milestone: Cited in Over 3,000 Peer-reviewed Articles
Topics include differential gene expression, gene-annotation enrichment analysis, and copy number analysis studies.
Acetate Supplements Shown to Speed Up Cancer Growth
A major compound produced in the gut by host bacteria.
Bacterial Defense Mechanism Targets Duchenne Muscular Dystrophy
Gene therapy approach could treat 60 percent of Duchenne Muscular Dystrophy patients.
Researchers Map Epigenome of More Than 100 Tissue and Cell Types
Researchers provide new insight into which parts of the genome are used to make a particular type of cell.
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