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"In-vitro studies on hydroxamic acid- CT DNA binding"
Rubi Khilari

In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.

Efficacy of Gene Therapy in Restoring Vision in Leber's Congenital Amaurosis
Elizabeth O'Donnell

The research reviews current knowledge of the genetic causes of Leber's congenital amaurosis (LCA) and the development of a gene therapy intervention for LCA. The efficacy as well as the limitations of this form of treatment are evaluated in detail and recommendations are made for the future directions of gene therapy for Leber's congenital amaurosis.

METHOD DEVELOPMENT FOR THE SIMULTANEOUS DETERMINATION OF METHYLMERCURY AND INORGANIC MERCURY IN SEAFOOD
Sergio Carneado, Ariane V. Zmozinski, Carmen Ibáñez-Palomino, Àngels Sahuquillo, José Fermín López-Sánchez, Márcia M. da Silva

This work reports the method development for the simultaneous determination of methylmercury (MeHg+) and inorganic mercury (iHg) species in seafood. The study focused on the extraction and quantification of MeHg+ by liquid chromatography coupled to on-line UV irradiation and cold vapour atomic fluorescence spectroscopy (LC-UV-HG-AFS), using HCl 4 mol L-1 as extractant agent.

Microextraction techniques combined with X-ray fluorescence spectrometry for determination of different metal ions in water
Karina Kocot (a), Beata Zawisza (a), Eva Marguí (b), Ignasi Queralt (c), Rafal Sitko (a)

In present work new preconcentration procedures combining microextraction techniques and X-ray fluorescence spectroscopy were developed. Proposed methodologies are promising tools for multielemental analysis enabling detection of natural pollutants in different water samples.

Recent Technical Developments in the Standardized Separation and Measurement of Extracellular Vesicles
Amy Phillips (1), Robert Vogel(2), and Murray F. Broom(1)

We present robust and practical solutions for the standardization of EV isolation and concentration measurement. EV concentration also needs to have a defined size range. With these solutions, significant improvement in the reproducibility and comparability of results between different researchers is possible.

Novel Approaches to High-throughput Measurements of Replicative Lifespan in Yeast by Microfluidic Size Sorting and Genetic Engineering
Ilka Lewrenz, Stephanie Wälter, Jacqueline Franke

Development of a high-throughput screen utilizing a microfluidic device and a linearly growing yeast strain to simultaneously test the influence of various drugs on the replicative lifespan of yeast.

Automated Fluorescence Detection and Imaging of RNA Species in Live Cells
Paul Held, Victor Koong, Don Weldon, Peter Banks

This poster describes the detection and quantification of RNA species in Live cells through automated imaging.

Identification and Characterisation of Novel Positive Allosteric Modulators of the Galanin 2 Receptor
Hayley Jones

An HTS against GalR2 was carried out to find novel PAMs to treat neuropathic pain.

The Longest Way Round is the Shortest Way Home: HTS Assay Development for Complex Multi-domain Protein Kinases
Doris Hafenbrandl, Vanessa Nardese, Maria Cristina Sidoli, Valeria Wanke, Mariantonietta Rubino and Daniele Carettoni

This study strongly supports the possibility to overcome the major bottlenecks in the production of long kinase recombinant forms, in order to perform drug discovery programmes with proteins more closely preserving the structural and functional properties of the native enzymes.

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Showing Results 51 - 60 of 309
Scientific News
Gene Variant Linked to Smoking Longer, Getting Lung Cancer Sooner
Smokers with a particular variation in a nicotine receptor gene were more likely to continue smoking for four years.
Scientists Discover Protein That Boosts Immunity to Viruses and Cancer
Researchers now developing a gene therapy designed to boost the infection-fighting cells.
Paternal Sperm May Hold Clues to Autism
Tags on DNA from fathers’ sperm linked to children’s autism symptoms.
NIH Study Finds Genetic Link for Rare Intestinal Cancer
Researchers recommend screening for people with family history.
Potential For Prediction Of Progression For Early Form Of Breast Cancer
Scientists in Manchester have identified a way to potentially predict which patients with an early form of breast cancer will experience disease progression.
Systems-Wide Genetic Investigation Of Blood Pressure Regulation
A genetic investigation of individuals in the Framingham Heart Study may prove useful to identify novel targets for the prevention or treatment of high blood pressure.
Tumor-Only Genetic Sequencing May Misguide Cancer Treatment in Nearly Half of All Patients
Johns Hopkins scientists say the genetic code of tumors must be compared to patients’ noncancer genome to get a true picture.
Genetic Link For Rare Intestinal Cancer
Researchers recommend screening for people with family history.
New Genomic Research Amends Earlier Triple Negative Breast Cancer Finding
Previously reported molecular finding unable to be validated.
Understanding the Behaviour of Cells in Cancer Metastasis
LaVison BioTec report on the research of Professor Kurt I Anderson and his groups' studies of cell migration in the context of cancer metastasis at the Beatson Institute for Cancer Research.
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