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Unravelling the Role of Key Genes and DNA Methylation in Blood Cell Malignancies
Researchers from the University of Nebraska Medical Center have demonstrated the role of Dnmt3a in safeguarding normal haematopoiesis.
Genes Help Track Odd Migrations of Zika Mosquitoes
Study shows that mosquitoes carrying Zika virus or Dengue fever a genetically distinct around the world.
Editing Gene Mutations in Anemia
Researchers successfully use a new gene editing strategy to correct mutations that cause a form of anemia.
Lab-on-a-Chip to Help Detect Cancer
In this podcast, we speak to Gustavo Stolovitsky to learn about his career and the work he is doing at IBM Research.
Rare Immunodeficiency Yields Unexpected Insights
Scientists uncover previously unknown gene mutation revealing the role of a key molecule involved in immune cell development.
Driving Mosquito Evolution to Fight Malaria
Researchers propose insect repellent in conjunction with insecticides to extend current insecticide lifetime.
Tumor Markers Reveal Lethality Of Bladder Cancers
Researchers found that detection of certain tumor cells in early stage cancers helps identify high-risk cancers.
Gene Editing Corrects Sickle Cell Mutation
Researchers demonstrate a potential pathway to developing gene-editing treatments for sickle cell disease.
ALS Study Reveals Role of RNA-Binding Proteins
The findings are a significant step forward in validating RNA-based therapy as a treatment for ALS.
Observing Direct Inheritance of Gene-Silencing RNA
Research has allowed for the observation of double-stranded RNA molecule being passed from parent to offspring in roundworms.
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An Integrated Solution to Simplify Library Preparation and Multiplexing for NimbleGen Sequence Capture
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Bioo Scientific

Targeted sequencing is an important tool in analyzing disease or exome mutations. In this study, we describe how Bioo Scientific’s NEXTFlex™ DNA Pre-Capture Combo Library construction kits were used in conjunction with NimbleGen Sequence Capture technology to obtain high coverage comparative genomic data from a panel of human HapMap DNA samples. We identified 96-98% of known HapMap SNPs in the NimbleGen SeqCap EZ Exome v3.0 (64 Mb) and SeqCap EZ Design – Comprehensive Cancer Design (3.9 Mb) probes with a high percentage of reads mapping to the targeted regions. This study illustrates both the ability of Bioo Scientific’s NEXTFlex library construction kit to produce high-quality material for NGS, and the robust performance of the NimbleGen Sequence Capture technology.

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