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Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Genetics Control Regenerative Properties Of Stem Cells
Researchers define how genetic factors control regenerative properties of blood-forming stem cells.
Diabetes Missing Link Discovered
Researchers from the University of Auckland have shown that beta catenin plays a vital role in the control of insulin release from the pancreas.
Study Reveals New Role for Hippo Pathway in Suppressing Cancer Immunity
Hippo pathway signaling regulates organ size by moderating cell growth, apoptosis and stem cell renewal, but dysregulation contributes to cancer development.
Gene-Editing Improves Vision in Blind Rats
Scientists developed a targeted gene-replacement technique that can modify genes in both dividing and non-dividing cells in living animals.
Gene Editing Yields Tomatoes That Ripen Weeks Earlier
Research team develop method to make tomato plants flower and ripen fruit two weeks faster than current growth rates.
Exploring the Genome of the River Blindness Parasite
Researchers have decoded the genome of the parasite that causes the skin and eye infection known as river blindness.
Gene Therapy Maintains Clotting Factor for Hemophilia Patients
Following a single gene therapy dose, the highest levels of an essential blood clotting factor IX were observed in hemophilia B patients.
Unexpected Role for Epigenetic Enzymes in Cancer
Researchers use epigenetics to identify the role of an enzyme family as regulators of genetic message interpretation in yeast.
Genetic Links to Brain Cancer Cell Growth
Researchers discover clues to tumour behaviour from genetic differences between brain cancer cells and normal tissue cells.
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An Integrated Solution to Simplify Library Preparation and Multiplexing for NimbleGen Sequence Capture
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Bioo Scientific

Targeted sequencing is an important tool in analyzing disease or exome mutations. In this study, we describe how Bioo Scientific’s NEXTFlex™ DNA Pre-Capture Combo Library construction kits were used in conjunction with NimbleGen Sequence Capture technology to obtain high coverage comparative genomic data from a panel of human HapMap DNA samples. We identified 96-98% of known HapMap SNPs in the NimbleGen SeqCap EZ Exome v3.0 (64 Mb) and SeqCap EZ Design – Comprehensive Cancer Design (3.9 Mb) probes with a high percentage of reads mapping to the targeted regions. This study illustrates both the ability of Bioo Scientific’s NEXTFlex library construction kit to produce high-quality material for NGS, and the robust performance of the NimbleGen Sequence Capture technology.

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