Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>Resources>Application Notes>This Application Note
  Application Notes
Scientific News
Unravelling the Role of Key Genes and DNA Methylation in Blood Cell Malignancies
Researchers from the University of Nebraska Medical Center have demonstrated the role of Dnmt3a in safeguarding normal haematopoiesis.
Genes Help Track Odd Migrations of Zika Mosquitoes
Study shows that mosquitoes carrying Zika virus or Dengue fever a genetically distinct around the world.
Editing Gene Mutations in Anemia
Researchers successfully use a new gene editing strategy to correct mutations that cause a form of anemia.
Lab-on-a-Chip to Help Detect Cancer
In this podcast, we speak to Gustavo Stolovitsky to learn about his career and the work he is doing at IBM Research.
Rare Immunodeficiency Yields Unexpected Insights
Scientists uncover previously unknown gene mutation revealing the role of a key molecule involved in immune cell development.
Driving Mosquito Evolution to Fight Malaria
Researchers propose insect repellent in conjunction with insecticides to extend current insecticide lifetime.
Tumor Markers Reveal Lethality Of Bladder Cancers
Researchers found that detection of certain tumor cells in early stage cancers helps identify high-risk cancers.
Gene Editing Corrects Sickle Cell Mutation
Researchers demonstrate a potential pathway to developing gene-editing treatments for sickle cell disease.
ALS Study Reveals Role of RNA-Binding Proteins
The findings are a significant step forward in validating RNA-based therapy as a treatment for ALS.
Observing Direct Inheritance of Gene-Silencing RNA
Research has allowed for the observation of double-stranded RNA molecule being passed from parent to offspring in roundworms.
Scroll Up
Scroll Down

A global abstract analysis of selected histone-modifying enzymes using AKS
Bookmark and Share

Active Motif

With over 8.4 million PubMed abstracts and with 1000s of new abstracts added daily, it is physically impossible for any conscientious researcher to keep current with all of the newly published research. Most scientists rely on simple information-retrieval techniques to obtain scientific articles pertaining to a topic of interest. However, new sophisticated software programs have been developed to try to understand how biological concepts in scientific literature are used and how these concepts correspond to the query term provided by the user. When searching PubMed abstracts, most life science researchers do not want to be experts in text mining techniques, but simply want to have an all-encompassing understanding of the published information about a biomolecule and its relationship to disease or other biological entities. Therefore, global abstract analysis (GAA) is a novel approach for examining the complexity of information described in PubMed abstracts.

GAA was employed to illustrate how this technique can help uncover additional biological relationships, scientific information, and overall publication trends of a particular collection of biomolecules. In this study we selected twelve histone-modifying enzymes (1). They are important because several common post-translational modifications are driven by these types of histone-modifying enzymes. These resulting modifications influence the structure of chromatin and the dynamic interaction of transcriptional machinery. The modifications include: methylation, demethylation, acetylation, deacetylation, ubiquitination, sumoylation and phosphorylation. Methylation and acetylation are the typical control points between switching from gene silencing to active transcription, whereas hyperacetylated histone tails are associated with active transcription. In addition, ubiquitination is implicated in transcriptional regulation by polycomb silencing and regulation of chromatin structure, while phosphorylated residues on histone tails can be markers for chromatin condensation in mitosis, DNA repair, or apoptosis.

Distinct from traditional simple text search methods, the technique of GAA gives an extensive overview and historical synopsis of the published knowledge of these fascinating histone-modifying enzymes. In this report we describe the application of GAA to a group of disease-associated enzymes and demonstrate how a complete GAA can be developed for any targeted collection of biomolecules for pathway construction, biomarker discovery, or early investigative studies.

Further Information

Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,200+ scientific videos