Corporate Banner
Satellite Banner
Technology Networks Header
Tuesday, October 21, 2014
Technology Networks
 
Register | Sign in
Home Page > Videos > Bacterial Genomic Changes Revealed through Next-generation Sequencing Data Analysis
  Videos

Return

Bacterial Genomic Changes Revealed through Next-generation Sequencing Data Analysis
SELECTBIO

Neisseria gonorrhoeae is capable of causing gonorrhoea and more complex diseases in the human host. The Correia Repeat Enclosed Element (CREE), an IS-like element, has been predicted to be mobile within the neisserial genomes. Although there is evidence of ancestral movement of these elements, no previous study has provided evidence for current mobilisation. The CREE has the ability to alter gene expression and regulation in many ways: by insertional mutagenesis; by introducing promoter elements; and by generating mRNA processing sites. Previous studies have compared the genomic locations of CREE in the Neisseria spp., demonstrating that otherwise identical regions have either the element or the target TA insertion site. We report here movement of CREE, through inversion of the element at its chromosomal location. Analysis of Ion Torrent generated genome sequence data from N. gonorrhoeae strain NCCP11945 revealed a total of 37 CREE inversions that have the capability to alter gene expression in N. gonorrhoeae through the previously determined activities of the sequence features of these elements.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
Shaking Up Cell Biology
Researchers focus in on decades old mystery.
Researchers Describe New Method for Cell Line Authentication
SNP profiling, an effective method to detect misidentification, contamination, and chromosomal abnormalities in mouse cell lines.
New Lead for Potential Parkinson’s Treatment
Effects of high-risk Parkinson’s mutation are reversible.
New Test can Help Doctors Choose Best Treatment for Ovarian Cancer
ADNEX discriminate between benign and malignant tumours with a high level of accuracy.
Novel Mutations Discovered In Cats Provide Insight Into Human Eye Diseases
99 Lives Cat Genome Sequencing Initiative makes discoveries using Maverix analytic platform.
Study Finds Link Between Neural Stem Cell Overgrowth and Autism-like Behavior in Mice
UCLA researchers demonstrates how, in pregnant mice, inflammation can trigger an excessive division of neural stem cells.
All the Cell’s a Stage
Brian Strahl, PhD, and his band of biochemists unravel the complicated mysteries of the epigenetic code to find a culprit in cancer development.
Single Gene Mutation Eliminates ISG15
Single gene links susceptibility to rare infections with predisposition to autoimmune disease.
New Cancer Drug To Begin Trials In Multiple Myeloma Patients
Scientists at Imperial College London have developed a new cancer drug which they plan to trial in multiple myeloma patients by the end of next year.
ISB Gets $6.5 Million from NCI
Company has received two-year contract to create ‘Cancer Genomics Cloud’ with partners Google and SRA International.
Scroll Up
Scroll Down
Skyscraper Banner
Skyscraper Banner
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn
Go to LabTube.tv