Thursday, May 17, 2012
Technology Networks
Technology Networks
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 | Chemical Restriction Length Polymorphism (CLFP) for Detection and Characterization of Bacterial Pathogens Byron Brehm-Stecher, Iowa State University, speaking at Advances in Biosensors and Biotedection 2011. |
 | Applied Molecular Diagnostics in Solid Tumours: Past, Present and Future Dr Brendan Pang, National University Health System, speaking at Molecular Diagnostics Asia 2011. |
Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
GBI Research
The report provides key data, information and analysis of the major trends and issues in Personalized Medicine Market. The report provides a comprehensive insight into the role of Human Genomics and Proteomics to challenge traditional therapeutics.
Personalized Medicine for Cancer
GlobalData
The report is an essential source of information on the Personalized Medicine for Cancer . The report also provides insights on the companion diagnostics and marketed personalized drugs for cancer.
Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
High Throughput qPCR Assay Trends
HTStec
This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput real-time quantitative PCR (HT qPCR) assays carried out in January 2012.
Next-Gen Sequencing Trends 2011
HTStec
This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on next-generation sequencing (NGS) carried out in March 2011.
Biochips - Products, Applications, Technologies and End-Use Markets Growth Analysis, 2009-2015
Axis Research Mind
The report reviews the latest biochips market trends with a perceptive attempt to disclose the near-future growth prospects. An in-depth analysis on a geographic basis provides strategic business intelligence for life science sector investments. The study reveals profitable investment strategies for pharmaceutical manufacturers, biotechnology companies, laboratories, Contract Research Organizations (CROs), government organizations and many more in preferred locations.
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights
Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Epigenetics Market Trends 2011
Select Biosciences Ltd
Epigenetics research efforts are growing around the world driven by the numerous documented associations of epigenetic modifications with diseases—especially various types of cancers.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Advances in the Use of Biomarkers in Biochip and Microarray Testing: Innovative Technologies, Growth Opportunities and the Future Market Outlook
Business Insights
The microarray market (estimated at $788m for 2008, including about $130m in protein arrays) is forecast to grow by 9% per annum to $1322m in 2013. Diagnostic microarrays, currently with just $39m (5% of the total), are expected to reach $187m (14%) by 2013. The leading diagnostic application at present is cancer.
GBI Research
The report provides key data, information and analysis of the major trends and issues in Personalized Medicine Market. The report provides a comprehensive insight into the role of Human Genomics and Proteomics to challenge traditional therapeutics.
Personalized Medicine for Cancer
GlobalData
The report is an essential source of information on the Personalized Medicine for Cancer . The report also provides insights on the companion diagnostics and marketed personalized drugs for cancer.
Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
High Throughput qPCR Assay Trends
HTStec
This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput real-time quantitative PCR (HT qPCR) assays carried out in January 2012.
Next-Gen Sequencing Trends 2011
HTStec
This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on next-generation sequencing (NGS) carried out in March 2011.
Biochips - Products, Applications, Technologies and End-Use Markets Growth Analysis, 2009-2015
Axis Research Mind
The report reviews the latest biochips market trends with a perceptive attempt to disclose the near-future growth prospects. An in-depth analysis on a geographic basis provides strategic business intelligence for life science sector investments. The study reveals profitable investment strategies for pharmaceutical manufacturers, biotechnology companies, laboratories, Contract Research Organizations (CROs), government organizations and many more in preferred locations.
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights
Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Epigenetics Market Trends 2011
Select Biosciences Ltd
Epigenetics research efforts are growing around the world driven by the numerous documented associations of epigenetic modifications with diseases—especially various types of cancers.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Advances in the Use of Biomarkers in Biochip and Microarray Testing: Innovative Technologies, Growth Opportunities and the Future Market Outlook
Business Insights
The microarray market (estimated at $788m for 2008, including about $130m in protein arrays) is forecast to grow by 9% per annum to $1322m in 2013. Diagnostic microarrays, currently with just $39m (5% of the total), are expected to reach $187m (14%) by 2013. The leading diagnostic application at present is cancer.
Study of Helicobacter pylori Genotype Status in Saliva, Dental Plaques, Stool and Gastric Biopsy Samples
This study aimed to compare H. pylori cagA and the vacA allelic status among strains isolated from saliva, dental plaque, gastric biopsies and stool samples in the same patient with dyspepsia manifestations in order to evaluate the mode of transmission of H. pylori infection.
Serious Bacterial Infection Biomarkers Uncovered using Transcriptomic Analysis
Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children.
Genetic Predictor of Breast Cancer Response to Chemotherapy
Gene expression 'signatures' to measure the susceptibility of tumor cells to chemotherapy.
New Biomarkers Could Offer Vital Clues for Cancer Research
European funding for cancer research has led to some interesting results in recent years, says Carl-Johan Ivarsson, CEO at Qlucore.
National Data Center for Cancer Genome Research
In the wake of personalized medicine, scientists at the University of California, Santa Cruz, make progress in the management and analysis of large data sets.
Using the Sequenced Genome to Tackle Disease
UMass Amherst geneticist develops tool to identify genes important in disease and for tailoring individual treatment.
Selection of Suitable Reference Genes for RT-qPCR Analyses in Cyanobacteria
In this work we have validated candidate reference genes for accurate normalization of RT-qPCR data in cyanobacteria. Several genes were selected and their transcription analyzed in three morphological distinct organisms.
DNA Methylation Analysis of Bone Marrow Cells at Diagnosis of Acute Lymphoblastic Leukemia and at Remission
The aim of this study was to identify genes that display aberrant DNA methylation independently of cytogenetic ALL subtype for further mechanistic studies of ALL.
Integrated Analyses of microRNAs Demonstrate Their Widespread Influence on Gene Expression in High-Grade Serous Ovarian Carcinoma
The Cancer Genome Atlas (TCGA) Network recently catalogued the molecular aberrations in 487 high-grade serous ovarian cancers. This study surveys the miRNAs, in the context of their predicted gene targets.
Enzo Biochem Launches Test for Measuring Risk of Colorectal Cancer
Company developing pipeline of new platforms and assays for molecular diagnostic use.
This study aimed to compare H. pylori cagA and the vacA allelic status among strains isolated from saliva, dental plaque, gastric biopsies and stool samples in the same patient with dyspepsia manifestations in order to evaluate the mode of transmission of H. pylori infection.
Serious Bacterial Infection Biomarkers Uncovered using Transcriptomic Analysis
Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children.
Genetic Predictor of Breast Cancer Response to Chemotherapy
Gene expression 'signatures' to measure the susceptibility of tumor cells to chemotherapy.
New Biomarkers Could Offer Vital Clues for Cancer Research
European funding for cancer research has led to some interesting results in recent years, says Carl-Johan Ivarsson, CEO at Qlucore.
National Data Center for Cancer Genome Research
In the wake of personalized medicine, scientists at the University of California, Santa Cruz, make progress in the management and analysis of large data sets.
Using the Sequenced Genome to Tackle Disease
UMass Amherst geneticist develops tool to identify genes important in disease and for tailoring individual treatment.
Selection of Suitable Reference Genes for RT-qPCR Analyses in Cyanobacteria
In this work we have validated candidate reference genes for accurate normalization of RT-qPCR data in cyanobacteria. Several genes were selected and their transcription analyzed in three morphological distinct organisms.
DNA Methylation Analysis of Bone Marrow Cells at Diagnosis of Acute Lymphoblastic Leukemia and at Remission
The aim of this study was to identify genes that display aberrant DNA methylation independently of cytogenetic ALL subtype for further mechanistic studies of ALL.
Integrated Analyses of microRNAs Demonstrate Their Widespread Influence on Gene Expression in High-Grade Serous Ovarian Carcinoma
The Cancer Genome Atlas (TCGA) Network recently catalogued the molecular aberrations in 487 high-grade serous ovarian cancers. This study surveys the miRNAs, in the context of their predicted gene targets.
Enzo Biochem Launches Test for Measuring Risk of Colorectal Cancer
Company developing pipeline of new platforms and assays for molecular diagnostic use.
KineMed and CHDI Foundation Collaborate
KineMed’s isotopic labeling technology and analytical expertise will be applied to measure in vivo production rates of huntingtin protein as a potential biomarker of disease state.
BIOCRATES Goes Spain and Turkey
Austrian diagnostic expert in personalized medicine continues to expand its European distribution network.
Eureka Genomics Launches a Novel Custom Genotyping Service
This platform addresses the gap between traditional array technologies and multiplex PCR.
Horizon and H3 Biomedicine to Collaborate
H3 Biomedicine to employ Horizon’s unique gene editing technology and isogenic cell lines to validate genetically defined drug targets for development of cancer therapeutics.
Dr Alan Schafer to head Population Genetics as CEO
Schafer brings deep experience in research, “big pharma” management and building new businesses.
Ezose Sciences and Hirosaki University to Collaborate in Glycomics Research
International study will focus on urologic cancers through use of Ezose’s GlycanMap® platform.
QIAGEN and Cardinal Health Collaborate to Offer Molecular Diagnostic Products to Smaller and Mid-Sized U.S. Hospitals
Collaboration creates distribution channel to previously underserved market segment.
Vermillion Resolves Non-Contingent Claims with Bio-Rad
Vermillion to be returned more than $1 million from escrow.
NHGRI to Develop Revolutionary Technologies for Exploring Genome Function
NHGRI has awarded 10 grants, totaling $10.5 million, to develop revolutionary technologies that will help researchers identify millions of genomic elements that play a role in determining what genes are expressed and at what levels in different cells.
Denator-led Research Project Aims to Develop New Biomarker Discovery Platform for Cancer Diagnostics
Project awarded funding from the EU Eurostars programme.
KineMed’s isotopic labeling technology and analytical expertise will be applied to measure in vivo production rates of huntingtin protein as a potential biomarker of disease state.
BIOCRATES Goes Spain and Turkey
Austrian diagnostic expert in personalized medicine continues to expand its European distribution network.
Eureka Genomics Launches a Novel Custom Genotyping Service
This platform addresses the gap between traditional array technologies and multiplex PCR.
Horizon and H3 Biomedicine to Collaborate
H3 Biomedicine to employ Horizon’s unique gene editing technology and isogenic cell lines to validate genetically defined drug targets for development of cancer therapeutics.
Dr Alan Schafer to head Population Genetics as CEO
Schafer brings deep experience in research, “big pharma” management and building new businesses.
Ezose Sciences and Hirosaki University to Collaborate in Glycomics Research
International study will focus on urologic cancers through use of Ezose’s GlycanMap® platform.
QIAGEN and Cardinal Health Collaborate to Offer Molecular Diagnostic Products to Smaller and Mid-Sized U.S. Hospitals
Collaboration creates distribution channel to previously underserved market segment.
Vermillion Resolves Non-Contingent Claims with Bio-Rad
Vermillion to be returned more than $1 million from escrow.
NHGRI to Develop Revolutionary Technologies for Exploring Genome Function
NHGRI has awarded 10 grants, totaling $10.5 million, to develop revolutionary technologies that will help researchers identify millions of genomic elements that play a role in determining what genes are expressed and at what levels in different cells.
Denator-led Research Project Aims to Develop New Biomarker Discovery Platform for Cancer Diagnostics
Project awarded funding from the EU Eurostars programme.
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Metal Polymers, A Glue to Immobilise Proteins Onto Synthetic Surfaces
Anteo Diagnostics
The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.
Gene Expression Profiling: qPCR Toolkit for Quality Control
TATAA Biocenter
TATAA Biocenter explain how they developedand optimized high-throughput gene expression qPCR with ValidPrime quality control, compensating for inter-run variations.
Antigen Determination in Autoimmune Hepatitis Type1
Institute of Liver and Biliary Sciences
Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.
Is it possible to quantify and rank the quality of several lists of significant genes found with gene expression profiling by different methods?
(1) Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, Germany; (2) Rheumatology, Charité CCM Berlin Germany
High Performance Chip Data Analysis (HPCDA) improves expression profiling of Affymetrix chips via Bioretis database: you can easily use the default parameters and are sure to get the optimum of true positive results, independant of number of significant genes in your dataset. Gene List Significance Index (GLSI) quantifies quality of gene lists. With GLSI its easily judged which normalization/analyzing method gives better results. HPCDA score ranks by relevance.
Identification of novel autoantigensin patients with liver autoimmune diseases by Protein MicroArray
1Fondazione INGM, Istituto Nazionale Genetica Molecolare, Milan; 2Fondazione IRCCS Ospedale Maggiore Policlinico, Milano; 3Policlinico Sant’Orsola, Bologna; 4Azienda Ospedaliera Universitaria Pisana,
The characterization of autoimmune disease-specific biomarkers are of primary importance for the development of diagnostic tools and the comprehension of pathogenetic mechanisms leading to autoimmunity. To this aim a protein microarray was employed to analyze serum samples from patients with autoimmune hepatitis (e.g. AIH & PBC) and of healthy as controls. A panel of autoantigens able to discriminate among the groups of patients was identified for potential use as biomarkers.
Intronic polymorphisms in Daucus carota AOX2b generate putative genotype specific miRNA
University of Évora
A study in the carrot alternative oxidase gene DcAOX2b from several individual plant genotypes of D. carota cv. Rotin revealed the frequent occurrence of intron length polymorphisms (ILPs). Here we will present an in silico analysis performed in order to identify putative miRNA sites at three different sizes of intron 1. The overall research approach aims to develop functional marker candidates for carrot plant breeding.
Gene expression analysis of CD14+ monocytes immunomagnetically separated directly from whole blood: adaptation of protocols towards clinical trial requirements
1Miltenyi Biotec GmbH
Peripheral blood is widely used as starting material for biomarker discovery and validation using molecular biology technologies. The vast majority of currently published transcriptome data is based on RNA derived either from stabilized whole blood or peripheral blood mononuclear cells (PBMCs). Here, gene expression profiling studies and SOPs for fast, easy and specific manual or automated isolation of monocytes directly from whole blood are being described.
Integrated In Silico Analysis of NGS Prostate Cancer Data via High-Resolution RNA-Seq Analysis
Ingenuity Systems, CLC Bio
The goal: To get novel insights into the mechanisms of prostate adenocarcinoma by leveraging next generation sequencing (NGS) data, particularly human transcriptome data, through in silico data analysis and interpretation by Ingenuity’s IPA® software. CLC Genomics Workbench and CLC Genomics Server helped us assess short read RNA-Seq data.
Gene Expression Profiling of Archived FFPE Samples
Miltenyi Biotech
According to the BBMRI (Biobanking and Biomolecular Resources Research Infrastructure) about 8,000,000 formalin-fixed paraffin-embedded (FFPE) samples derived from a multitude of different diseases have been collected in medical centers and biobanks all over Europe during the last decades.
Differential Expression and Localization of Dicer1 and Ovarian Steroid Hormone Receptors in Human Fallopian Tubes
Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Dicer1 expression is upregulated in cell-specific fashion in human Fallopian tubes during ovulation. The stage-dependent expression of Dicer1 and its correlation with ERa, ERß2, and PRB mRNA suggests that tubal Dicer1 helps regulate tubal expression of steroid hormone receptors in a cycle-dependent manner and may contribute to tubal transport in humans.
Anteo Diagnostics
The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.
Gene Expression Profiling: qPCR Toolkit for Quality Control
TATAA Biocenter
TATAA Biocenter explain how they developedand optimized high-throughput gene expression qPCR with ValidPrime quality control, compensating for inter-run variations.
Antigen Determination in Autoimmune Hepatitis Type1
Institute of Liver and Biliary Sciences
Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.
Is it possible to quantify and rank the quality of several lists of significant genes found with gene expression profiling by different methods?
(1) Deutsches Rheuma-Forschungszentrum (DRFZ) Berlin, Germany; (2) Rheumatology, Charité CCM Berlin Germany
High Performance Chip Data Analysis (HPCDA) improves expression profiling of Affymetrix chips via Bioretis database: you can easily use the default parameters and are sure to get the optimum of true positive results, independant of number of significant genes in your dataset. Gene List Significance Index (GLSI) quantifies quality of gene lists. With GLSI its easily judged which normalization/analyzing method gives better results. HPCDA score ranks by relevance.
Identification of novel autoantigensin patients with liver autoimmune diseases by Protein MicroArray
1Fondazione INGM, Istituto Nazionale Genetica Molecolare, Milan; 2Fondazione IRCCS Ospedale Maggiore Policlinico, Milano; 3Policlinico Sant’Orsola, Bologna; 4Azienda Ospedaliera Universitaria Pisana,
The characterization of autoimmune disease-specific biomarkers are of primary importance for the development of diagnostic tools and the comprehension of pathogenetic mechanisms leading to autoimmunity. To this aim a protein microarray was employed to analyze serum samples from patients with autoimmune hepatitis (e.g. AIH & PBC) and of healthy as controls. A panel of autoantigens able to discriminate among the groups of patients was identified for potential use as biomarkers.
Intronic polymorphisms in Daucus carota AOX2b generate putative genotype specific miRNA
University of Évora
A study in the carrot alternative oxidase gene DcAOX2b from several individual plant genotypes of D. carota cv. Rotin revealed the frequent occurrence of intron length polymorphisms (ILPs). Here we will present an in silico analysis performed in order to identify putative miRNA sites at three different sizes of intron 1. The overall research approach aims to develop functional marker candidates for carrot plant breeding.
Gene expression analysis of CD14+ monocytes immunomagnetically separated directly from whole blood: adaptation of protocols towards clinical trial requirements
1Miltenyi Biotec GmbH
Peripheral blood is widely used as starting material for biomarker discovery and validation using molecular biology technologies. The vast majority of currently published transcriptome data is based on RNA derived either from stabilized whole blood or peripheral blood mononuclear cells (PBMCs). Here, gene expression profiling studies and SOPs for fast, easy and specific manual or automated isolation of monocytes directly from whole blood are being described.
Integrated In Silico Analysis of NGS Prostate Cancer Data via High-Resolution RNA-Seq Analysis
Ingenuity Systems, CLC Bio
The goal: To get novel insights into the mechanisms of prostate adenocarcinoma by leveraging next generation sequencing (NGS) data, particularly human transcriptome data, through in silico data analysis and interpretation by Ingenuity’s IPA® software. CLC Genomics Workbench and CLC Genomics Server helped us assess short read RNA-Seq data.
Gene Expression Profiling of Archived FFPE Samples
Miltenyi Biotech
According to the BBMRI (Biobanking and Biomolecular Resources Research Infrastructure) about 8,000,000 formalin-fixed paraffin-embedded (FFPE) samples derived from a multitude of different diseases have been collected in medical centers and biobanks all over Europe during the last decades.
Differential Expression and Localization of Dicer1 and Ovarian Steroid Hormone Receptors in Human Fallopian Tubes
Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Dicer1 expression is upregulated in cell-specific fashion in human Fallopian tubes during ovulation. The stage-dependent expression of Dicer1 and its correlation with ERa, ERß2, and PRB mRNA suggests that tubal Dicer1 helps regulate tubal expression of steroid hormone receptors in a cycle-dependent manner and may contribute to tubal transport in humans.
A MIQE Case Study — Effect of RNA Sample Quality and Reference Gene Stability on Gene Expression Data
Bio-Rad Laboratories
In this study, the minichromosome maintenance (MCM) protein, MCM7, was selected as a model target gene to investigate the importance of appropriate reference gene selection and RNA sample quality as described by the MIQE guidelines.
Application of the Amplifluor® SNPs Genotyping System using a FLUOstar OPTIMA Microplate Reader
BMG Labtech
The detection of SNPs (single nucleotide polymorphisms) is an important tool for researchers in order to find mutations in DNA sequences. In this application note we describe a homogeneous fluorescence assay based on PCR. The Amplifluor® SNPs HT Genotyping System from Millipore was used to screen a number of samples with the help of the FLUOstar OPTIMA multidetection microplate reader from BMG LABTECH.
High Yield and Quality with Thermo Scientific Microtiter Deep Well 96 plates in KingFisher Flex Process
Thermo Fisher Scientific
The Thermo Scientific KingFisher Flex magnetic particle processor is specifically designed to automate the time-consuming sample preparation of proteins, nucleic acids and cells in 96-well plate formats.
Isolation and Purification of Genomic DNA and Viral RNA from Clinical Samples with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
The purification of DNA and RNA from clinical samples requires rapid and reliable processing of large quantities of samples. Automated purification of nucleic acids, proteins and cells with Thermo Scientific KingFisher Flex is a reproducible and high quality method, which produces excellent material for further analyses.
DNA Quantitation in Cuvette and TrayCell using the Thermo Scientific Multiskan GO Spectrophotometer
Thermo Fisher Scientific
This application note describes how to perform photometric DNA quantitation and qualification measurements with the Thermo Scientific Multiskan GO microplate and cuvette spectrophotometer in various cuvette formats.
Rapid and Reproducible DNA Isolation from 1 ml of Whole Blood with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
This application note shows the benefits of KingFisher Flex by using genomic DNA isolation from blood as an example.
Validated Luminometric DLR™ Reporter Gene Assay with Thermo Scientific Varioskan® Flash
Thermo Fisher Scientific
One of the most common luminometric assays is Dual Luciferase® Reporter Assay from Promega corp. This application note shows how this assay is performed with Varioskan Flash multitechnology microplate reader. The note includes the performance of the normal DLR assay and results from some tests showing important aspects of the basic behaviour and performance of the DLR™ chemistry. This paper describes the overall efficiency of the Varioskan Flash in the measurement of DLR assay.
Simultaneous Detection of Copy Number and Copy-Neutral LOH Using a Single Microarray
Agilent Technologies
Application note describing the Agilent SurePrint G3 CGH+SNP microarray platform for the simultaneous detection of copy number and copy-neutral genetic aberrations.
Novel ProteoPrep® 20 Immunoaffinity Depletion Resin for Human Plasma
Sigma Aldrich
Sigma’s ProteoPrep® 20 Plasma Immunodepletion Kit specifically removes 20 of the most abundant proteins from human plasma or serum in preparation for two-dimensional electrophoresis. The technology specifically removes twenty of the top high abundance proteins utilizing conventional antibodies coupled with small recombinant immunoaffinity ligands. The ProteoPrep 20 technology is advancing the frontier of biomarker discovery.
Bio-Rad Laboratories
In this study, the minichromosome maintenance (MCM) protein, MCM7, was selected as a model target gene to investigate the importance of appropriate reference gene selection and RNA sample quality as described by the MIQE guidelines.
Application of the Amplifluor® SNPs Genotyping System using a FLUOstar OPTIMA Microplate Reader
BMG Labtech
The detection of SNPs (single nucleotide polymorphisms) is an important tool for researchers in order to find mutations in DNA sequences. In this application note we describe a homogeneous fluorescence assay based on PCR. The Amplifluor® SNPs HT Genotyping System from Millipore was used to screen a number of samples with the help of the FLUOstar OPTIMA multidetection microplate reader from BMG LABTECH.
High Yield and Quality with Thermo Scientific Microtiter Deep Well 96 plates in KingFisher Flex Process
Thermo Fisher Scientific
The Thermo Scientific KingFisher Flex magnetic particle processor is specifically designed to automate the time-consuming sample preparation of proteins, nucleic acids and cells in 96-well plate formats.
Isolation and Purification of Genomic DNA and Viral RNA from Clinical Samples with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
The purification of DNA and RNA from clinical samples requires rapid and reliable processing of large quantities of samples. Automated purification of nucleic acids, proteins and cells with Thermo Scientific KingFisher Flex is a reproducible and high quality method, which produces excellent material for further analyses.
DNA Quantitation in Cuvette and TrayCell using the Thermo Scientific Multiskan GO Spectrophotometer
Thermo Fisher Scientific
This application note describes how to perform photometric DNA quantitation and qualification measurements with the Thermo Scientific Multiskan GO microplate and cuvette spectrophotometer in various cuvette formats.
Rapid and Reproducible DNA Isolation from 1 ml of Whole Blood with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
This application note shows the benefits of KingFisher Flex by using genomic DNA isolation from blood as an example.
Validated Luminometric DLR™ Reporter Gene Assay with Thermo Scientific Varioskan® Flash
Thermo Fisher Scientific
One of the most common luminometric assays is Dual Luciferase® Reporter Assay from Promega corp. This application note shows how this assay is performed with Varioskan Flash multitechnology microplate reader. The note includes the performance of the normal DLR assay and results from some tests showing important aspects of the basic behaviour and performance of the DLR™ chemistry. This paper describes the overall efficiency of the Varioskan Flash in the measurement of DLR assay.
Simultaneous Detection of Copy Number and Copy-Neutral LOH Using a Single Microarray
Agilent Technologies
Application note describing the Agilent SurePrint G3 CGH+SNP microarray platform for the simultaneous detection of copy number and copy-neutral genetic aberrations.
Novel ProteoPrep® 20 Immunoaffinity Depletion Resin for Human Plasma
Sigma Aldrich
Sigma’s ProteoPrep® 20 Plasma Immunodepletion Kit specifically removes 20 of the most abundant proteins from human plasma or serum in preparation for two-dimensional electrophoresis. The technology specifically removes twenty of the top high abundance proteins utilizing conventional antibodies coupled with small recombinant immunoaffinity ligands. The ProteoPrep 20 technology is advancing the frontier of biomarker discovery.
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