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 | Microelectronics Meets Microfluidics: Hybrid Integration of Sensors in Microfluidic Devices Holger Becker, Microfluidic ChipShop GmbH, speaking at Lab-on-a-Chip World Congress 2012 |
 | Single Cell Analysis of Transcriptional Heterogeneity in the Early Developing Kidney Professor Steve Potter, Cincinnati Children's Hospital Medical Center, speaking at Single Cell Analysis 2012 |
qPCR Assay Trends 2013
HTStec
HTStec's qPCR Assay Trends 2013 report was published on 15 April 2013. This 63 page market report summarizes the results of HTStec's 3rd industry-wide global web-based benchmarking survey on real-time quantitative PCR (qPCR) assays and instruments carried out in March 2013.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Companion Diagnostics and Personalized Medicine
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the companion diagnostics (CDx) and personalized medicine marketplace. Personalized medicine is a broad field with several stakeholders all of which must be aligned in order to capture the immense potential value in targeting therapeutics to the correct patient population—the field of stratified medicine.
MicroRNAs and Exosomes
Select Biosciences Ltd
In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
Single Cell Technologies Trends
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on single cell technologies carried out in June 2012.
Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
GBI Research
The report provides key data, information and analysis of the major trends and issues in Personalized Medicine Market. The report provides a comprehensive insight into the role of Human Genomics and Proteomics to challenge traditional therapeutics.
Personalized Medicine for Cancer
GlobalData
The report is an essential source of information on the Personalized Medicine for Cancer . The report also provides insights on the companion diagnostics and marketed personalized drugs for cancer.
Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
High Throughput qPCR Assay Trends
HTStec
This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput real-time quantitative PCR (HT qPCR) assays carried out in January 2012.
Next-Gen Sequencing Trends 2011
HTStec
This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on next-generation sequencing (NGS) carried out in March 2011.
HTStec
HTStec's qPCR Assay Trends 2013 report was published on 15 April 2013. This 63 page market report summarizes the results of HTStec's 3rd industry-wide global web-based benchmarking survey on real-time quantitative PCR (qPCR) assays and instruments carried out in March 2013.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Companion Diagnostics and Personalized Medicine
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the companion diagnostics (CDx) and personalized medicine marketplace. Personalized medicine is a broad field with several stakeholders all of which must be aligned in order to capture the immense potential value in targeting therapeutics to the correct patient population—the field of stratified medicine.
MicroRNAs and Exosomes
Select Biosciences Ltd
In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
Single Cell Technologies Trends
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on single cell technologies carried out in June 2012.
Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
GBI Research
The report provides key data, information and analysis of the major trends and issues in Personalized Medicine Market. The report provides a comprehensive insight into the role of Human Genomics and Proteomics to challenge traditional therapeutics.
Personalized Medicine for Cancer
GlobalData
The report is an essential source of information on the Personalized Medicine for Cancer . The report also provides insights on the companion diagnostics and marketed personalized drugs for cancer.
Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
High Throughput qPCR Assay Trends
HTStec
This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput real-time quantitative PCR (HT qPCR) assays carried out in January 2012.
Next-Gen Sequencing Trends 2011
HTStec
This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on next-generation sequencing (NGS) carried out in March 2011.
Biomarkers Found for Major Depressive Disorder
New research highlights biological and genetic markers associated with improved response to adjunctive L-Methylfolate in management of depression.
Biomarkers Discovered for Inflammatory Bowel Disease
Researchers have identified a number of biomarkers for inflammatory bowel disease (IBD), which could help with earlier diagnosis and intervention.
Your Immune System: On Surveillance in the War Against Cancer
Wake Forest Baptist Research looks at gene expression profiling in breast cancer.
Agilent Technologies Announces Winner of Fifth Annual Early Career Professor Award
Assistant Professor at Northwestern Recognized for Cancer Diagnostics Research.
Gene Discoveries Give Hope Against 'Brittle Bone' Disease
Scientists pinpoint mutation that appears to cause severe forms of bone loss.
Two MIT Professors Named Howard Hughes Medical Institute Investigators
Peter Reddien and Aviv Regev are among 27 top biomedical scientists selected nationwide.
microRNA Cooperation Mutes Breast Cancer Oncogenes
Turning up a few microRNAs a little may offer as much anti-breast-cancer activity as turning up one microRNA a lot – and without the unwanted side effects.
NYSCF Scientists Create Personalized Bone Substitutes from Skin Cells
For treatment of large bone defects and traumatic injuries.
Unusual Comparison Nets New Sleep Loss Marker
Paul Shaw, PhD, a researcher at Washington University School of Medicine in St. Louis, uses what he learns in fruit flies to look for markers of sleep loss in humans.
Lucigen Corporation and Research Corporation Technologies Announce Partnership
Partnership to commercialize and distribute the CleanColi™ Expression System, the first Escherichia coli (E. coli)-based recombinant system that lacks unwanted endotoxin.
New research highlights biological and genetic markers associated with improved response to adjunctive L-Methylfolate in management of depression.
Biomarkers Discovered for Inflammatory Bowel Disease
Researchers have identified a number of biomarkers for inflammatory bowel disease (IBD), which could help with earlier diagnosis and intervention.
Your Immune System: On Surveillance in the War Against Cancer
Wake Forest Baptist Research looks at gene expression profiling in breast cancer.
Agilent Technologies Announces Winner of Fifth Annual Early Career Professor Award
Assistant Professor at Northwestern Recognized for Cancer Diagnostics Research.
Gene Discoveries Give Hope Against 'Brittle Bone' Disease
Scientists pinpoint mutation that appears to cause severe forms of bone loss.
Two MIT Professors Named Howard Hughes Medical Institute Investigators
Peter Reddien and Aviv Regev are among 27 top biomedical scientists selected nationwide.
microRNA Cooperation Mutes Breast Cancer Oncogenes
Turning up a few microRNAs a little may offer as much anti-breast-cancer activity as turning up one microRNA a lot – and without the unwanted side effects.
NYSCF Scientists Create Personalized Bone Substitutes from Skin Cells
For treatment of large bone defects and traumatic injuries.
Unusual Comparison Nets New Sleep Loss Marker
Paul Shaw, PhD, a researcher at Washington University School of Medicine in St. Louis, uses what he learns in fruit flies to look for markers of sleep loss in humans.
Lucigen Corporation and Research Corporation Technologies Announce Partnership
Partnership to commercialize and distribute the CleanColi™ Expression System, the first Escherichia coli (E. coli)-based recombinant system that lacks unwanted endotoxin.
A New European Consortium to Boost our Understanding of IBD
A multi-modal integrated biomarker study Consortium to increase diagnostic precision in detection of the diseases.
Cenix BioScience and Debiopharm Sign Research Agreement
Both Companies collaborate to identify predictive biomarkers.
Syros Pharmaceuticals Appoints Eric R. Olson, Ph.D. as Chief Scientific Officer
Dr. Olson’s extensive experience in personalized medicine will support Syros’ mission to lead in gene control.
Mayo Clinic Forms Joint Venture with Cancer Genetics
OncoSpire Genomics will seek to discover and commercialize biomarkers for multiple cancer types.
Ignyta Announces Acquisition of Actagene Oncology and Entry into Oncology Personalized Medicine
Company adds world class drug discovery and development veterans to management and advisory team.
Olink Bioscience Appoints Sigma-Aldrich as Distributor of Duolink
Olink Bioscience will continue to develop the protein biomarker market.
OGT Supports Earlier Lupus Diagnosis
Superior sensitivity and specificity compared to current laboratory tests.
CardioDx Receives CAP Accreditation
CAP accreditation is awarded to clinical laboratories meeting the highest standards of excellence in quality laboratory practices.
Selventa Strengthens Intellectual Property for SysDx™ Approach to Personalized Medicine
Patent is core to Selventa’s SysDx™ approach to mining and comparing biological data for predicting a patient’s response or non-response to a drug.
Strategic Partnership Signals New Age of Stratified Medicine
Aridhia and Pivotal™ collaborating on revolutionary solutions for chronic disease management.
A multi-modal integrated biomarker study Consortium to increase diagnostic precision in detection of the diseases.
Cenix BioScience and Debiopharm Sign Research Agreement
Both Companies collaborate to identify predictive biomarkers.
Syros Pharmaceuticals Appoints Eric R. Olson, Ph.D. as Chief Scientific Officer
Dr. Olson’s extensive experience in personalized medicine will support Syros’ mission to lead in gene control.
Mayo Clinic Forms Joint Venture with Cancer Genetics
OncoSpire Genomics will seek to discover and commercialize biomarkers for multiple cancer types.
Ignyta Announces Acquisition of Actagene Oncology and Entry into Oncology Personalized Medicine
Company adds world class drug discovery and development veterans to management and advisory team.
Olink Bioscience Appoints Sigma-Aldrich as Distributor of Duolink
Olink Bioscience will continue to develop the protein biomarker market.
OGT Supports Earlier Lupus Diagnosis
Superior sensitivity and specificity compared to current laboratory tests.
CardioDx Receives CAP Accreditation
CAP accreditation is awarded to clinical laboratories meeting the highest standards of excellence in quality laboratory practices.
Selventa Strengthens Intellectual Property for SysDx™ Approach to Personalized Medicine
Patent is core to Selventa’s SysDx™ approach to mining and comparing biological data for predicting a patient’s response or non-response to a drug.
Strategic Partnership Signals New Age of Stratified Medicine
Aridhia and Pivotal™ collaborating on revolutionary solutions for chronic disease management.
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Protein Microarrays for Characterisation of the Bacillus anthracis ‘infectome’
Health Protection Agency
These studies provide an interesting insight into the transcriptome of virulent B. anthracis in a host infection environment.
Kidney Genes Expression in Hypertensive ISIAH Rats
ICIH SO RAN
The present study was performed to detect the key genes involved in the hypertensive phenotype manifestation in the ISIAH rats with inherited stress-induced arterial hypertension.
Variation in miRNA expression between TRV-infected tobacco plants is correlated with symptom severity and TRV-16K transcripts abundance
National Research Institute, Poland
In the present work, expression of certain miRNAs and their targets were investigated in three tobacco plants infected with Tobacco rattle virus (TRV) isolate Deb57 collected from Northern Poland in 2008.
Application of the SoftFocus® Design Strategy to Epigenetics Targets
BioFocus
Epigenetics describes the regulation of gene expression that occurs through DNA methylation and post translational modification of histones. The pharmaceutical industry has shown an explosion of interest in this field with new targets emerging.
Improved Ligation Specificity with Chemically Modified Ligation Components
TriLink BioTechnologies, Inc.
Ligases are gaining utility in molecular biology applications, such as nucleotide sequence detection, single nucleotide polymorphism (SNP) detection, protein detection and “next generation” sequencing by ligation.
Gene Expression from Pseudourine and 5-Methylcytidine Modified Messenger RNA
TriLink BioTechnologies, Inc.
Study objective was to develop methodologies for gram scale synthesis of messenger RNA (mRNA) for gene therapy applications, as well as scalable purification methods that yield highly expressed, persistent and non-toxic mRNA.
Random Homozygous Gene Perturbation (RHGP) as a Tool for Target Discovery and Validation
Functional Genetics
Random homozygous gene perturbation (RHGP) can identify and validate any host (cellular) gene target that directly causes a desired phenotype without requiring prior knowledge of the target. The central feature of RHGP is a unique lentiviral-based genetic element, known as a gene search vector (GSV) designed to interrogate the entire genome and identify target genes that cause the phenotype of interest.
Simultaneous RT-qPCR Measurement of 1718 Long Non-Coding RNAs
biogazelle
Massively parallel RNA-sequencing revealed that the human genome is pervasively transcribed, resulting in the production of thousands of non-coding RNA transcripts.
Development of an Automated Platform for HT Cloning and Expression
Novartis Vaccines and Diagnostics S.R.L.
Biomolecular protocols covering the whole cloning process were implemented in liquid handler robots. When compared to the manual approach, it was found that automation significantly speeds up HT cloning.
Metal Polymers, A Glue to Immobilise Proteins Onto Synthetic Surfaces
Anteo Diagnostics
The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.
Health Protection Agency
These studies provide an interesting insight into the transcriptome of virulent B. anthracis in a host infection environment.
Kidney Genes Expression in Hypertensive ISIAH Rats
ICIH SO RAN
The present study was performed to detect the key genes involved in the hypertensive phenotype manifestation in the ISIAH rats with inherited stress-induced arterial hypertension.
Variation in miRNA expression between TRV-infected tobacco plants is correlated with symptom severity and TRV-16K transcripts abundance
National Research Institute, Poland
In the present work, expression of certain miRNAs and their targets were investigated in three tobacco plants infected with Tobacco rattle virus (TRV) isolate Deb57 collected from Northern Poland in 2008.
Application of the SoftFocus® Design Strategy to Epigenetics Targets
BioFocus
Epigenetics describes the regulation of gene expression that occurs through DNA methylation and post translational modification of histones. The pharmaceutical industry has shown an explosion of interest in this field with new targets emerging.
Improved Ligation Specificity with Chemically Modified Ligation Components
TriLink BioTechnologies, Inc.
Ligases are gaining utility in molecular biology applications, such as nucleotide sequence detection, single nucleotide polymorphism (SNP) detection, protein detection and “next generation” sequencing by ligation.
Gene Expression from Pseudourine and 5-Methylcytidine Modified Messenger RNA
TriLink BioTechnologies, Inc.
Study objective was to develop methodologies for gram scale synthesis of messenger RNA (mRNA) for gene therapy applications, as well as scalable purification methods that yield highly expressed, persistent and non-toxic mRNA.
Random Homozygous Gene Perturbation (RHGP) as a Tool for Target Discovery and Validation
Functional Genetics
Random homozygous gene perturbation (RHGP) can identify and validate any host (cellular) gene target that directly causes a desired phenotype without requiring prior knowledge of the target. The central feature of RHGP is a unique lentiviral-based genetic element, known as a gene search vector (GSV) designed to interrogate the entire genome and identify target genes that cause the phenotype of interest.
Simultaneous RT-qPCR Measurement of 1718 Long Non-Coding RNAs
biogazelle
Massively parallel RNA-sequencing revealed that the human genome is pervasively transcribed, resulting in the production of thousands of non-coding RNA transcripts.
Development of an Automated Platform for HT Cloning and Expression
Novartis Vaccines and Diagnostics S.R.L.
Biomolecular protocols covering the whole cloning process were implemented in liquid handler robots. When compared to the manual approach, it was found that automation significantly speeds up HT cloning.
Metal Polymers, A Glue to Immobilise Proteins Onto Synthetic Surfaces
Anteo Diagnostics
The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.
Purification of Genomic DNA from Saliva Using Oragene® Discover Collection Kits and the Akonni TruTip® Extraction System on the Hamilton Microlab® STAR Liquid Handling Workstation
Hamilton
In the following studies, we have demonstrated the high precision of the automated TruTip extraction technology in processing genomic DNA from low-volume saliva samples and its advantage over competitors.
Rapid, High Throughput Extraction and Purification of Genomic DNA from Whole Blood Using the Akonni TruTip® Extraction System on the Hamilton Microlab® STAR Liquid Handling System
Hamilton
This application note demonstrates the high precision of the automated extraction system in processing genomic DNA from low volume whole blood samples and its advantage over competitors.
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Hamilton
The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.
A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1)
BMG LABTECH
Post-translational histone modifications like acetylation play a pivotal role in the epigenetic regulation of transcription. Catalyzing the latter reaction HDACs affect various cellular processes especially cancerogenesis. Although the mechanism of starting cancerogenesis by epigenetic events is not clearly explained inhibition of HDACs has highlighted as a viable principle in cancer therapy.
A MIQE Case Study — Effect of RNA Sample Quality and Reference Gene Stability on Gene Expression Data
Bio-Rad Laboratories
In this study, the minichromosome maintenance (MCM) protein, MCM7, was selected as a model target gene to investigate the importance of appropriate reference gene selection and RNA sample quality as described by the MIQE guidelines.
Application of the Amplifluor® SNPs Genotyping System using a FLUOstar OPTIMA Microplate Reader
BMG Labtech
The detection of SNPs (single nucleotide polymorphisms) is an important tool for researchers in order to find mutations in DNA sequences. In this application note we describe a homogeneous fluorescence assay based on PCR. The Amplifluor® SNPs HT Genotyping System from Millipore was used to screen a number of samples with the help of the FLUOstar OPTIMA multidetection microplate reader from BMG LABTECH.
High Yield and Quality with Thermo Scientific Microtiter Deep Well 96 plates in KingFisher Flex Process
Thermo Fisher Scientific
The Thermo Scientific KingFisher Flex magnetic particle processor is specifically designed to automate the time-consuming sample preparation of proteins, nucleic acids and cells in 96-well plate formats.
Isolation and Purification of Genomic DNA and Viral RNA from Clinical Samples with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
The purification of DNA and RNA from clinical samples requires rapid and reliable processing of large quantities of samples. Automated purification of nucleic acids, proteins and cells with Thermo Scientific KingFisher Flex is a reproducible and high quality method, which produces excellent material for further analyses.
DNA Quantitation in Cuvette and TrayCell using the Thermo Scientific Multiskan GO Spectrophotometer
Thermo Fisher Scientific
This application note describes how to perform photometric DNA quantitation and qualification measurements with the Thermo Scientific Multiskan GO microplate and cuvette spectrophotometer in various cuvette formats.
Rapid and Reproducible DNA Isolation from 1 ml of Whole Blood with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
This application note shows the benefits of KingFisher Flex by using genomic DNA isolation from blood as an example.
Hamilton
In the following studies, we have demonstrated the high precision of the automated TruTip extraction technology in processing genomic DNA from low-volume saliva samples and its advantage over competitors.
Rapid, High Throughput Extraction and Purification of Genomic DNA from Whole Blood Using the Akonni TruTip® Extraction System on the Hamilton Microlab® STAR Liquid Handling System
Hamilton
This application note demonstrates the high precision of the automated extraction system in processing genomic DNA from low volume whole blood samples and its advantage over competitors.
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Hamilton
The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.
A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1)
BMG LABTECH
Post-translational histone modifications like acetylation play a pivotal role in the epigenetic regulation of transcription. Catalyzing the latter reaction HDACs affect various cellular processes especially cancerogenesis. Although the mechanism of starting cancerogenesis by epigenetic events is not clearly explained inhibition of HDACs has highlighted as a viable principle in cancer therapy.
A MIQE Case Study — Effect of RNA Sample Quality and Reference Gene Stability on Gene Expression Data
Bio-Rad Laboratories
In this study, the minichromosome maintenance (MCM) protein, MCM7, was selected as a model target gene to investigate the importance of appropriate reference gene selection and RNA sample quality as described by the MIQE guidelines.
Application of the Amplifluor® SNPs Genotyping System using a FLUOstar OPTIMA Microplate Reader
BMG Labtech
The detection of SNPs (single nucleotide polymorphisms) is an important tool for researchers in order to find mutations in DNA sequences. In this application note we describe a homogeneous fluorescence assay based on PCR. The Amplifluor® SNPs HT Genotyping System from Millipore was used to screen a number of samples with the help of the FLUOstar OPTIMA multidetection microplate reader from BMG LABTECH.
High Yield and Quality with Thermo Scientific Microtiter Deep Well 96 plates in KingFisher Flex Process
Thermo Fisher Scientific
The Thermo Scientific KingFisher Flex magnetic particle processor is specifically designed to automate the time-consuming sample preparation of proteins, nucleic acids and cells in 96-well plate formats.
Isolation and Purification of Genomic DNA and Viral RNA from Clinical Samples with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
The purification of DNA and RNA from clinical samples requires rapid and reliable processing of large quantities of samples. Automated purification of nucleic acids, proteins and cells with Thermo Scientific KingFisher Flex is a reproducible and high quality method, which produces excellent material for further analyses.
DNA Quantitation in Cuvette and TrayCell using the Thermo Scientific Multiskan GO Spectrophotometer
Thermo Fisher Scientific
This application note describes how to perform photometric DNA quantitation and qualification measurements with the Thermo Scientific Multiskan GO microplate and cuvette spectrophotometer in various cuvette formats.
Rapid and Reproducible DNA Isolation from 1 ml of Whole Blood with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
This application note shows the benefits of KingFisher Flex by using genomic DNA isolation from blood as an example.
