Genotyping and Gene Expression - The Online Scientific Community

Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression
The transcription factors that control YAP gene expression are unknown. This study demonstrates that ß-catenin/TCF4 complexes bind a DNA enhancer element within the first intron of the YAP gene to drive YAP expression in CRC cells.

Launch of DIRECT - An Innovative Medicines Initiative Project for Personalized Medicine in Diabetes
Academia and the pharmaceutical industry working together in the fight against diabetes.

Estimation of drug-metabolizing capacity by CYP-genotyping and CYP-expression
The lack of therapeutic effect of drugs or the appearance of undesired side-effects is partly caused by differences or changes in drug metabolism. This work aims to introduce an approach of combining CYP-genotyping and CYP-phenotyping tools to estimate patients’ drug-metabolizing capacity.

Case Study Demonstrates Importance of MIQE for qPCR Data Analysis
Published by Bio-Rad Laboratories, Inc. this case study demonstrates how real-time PCR can lead to erroneous conclusions if the key steps set out in the MIQE guidelines are not followed.

Transformational Fruit Fly Genome Catalog Completed
Scientists now have a reference manual that should speed gene discoveries in everything from pest control to personalized medicine.

FDA Approves KALYDECO™ (ivacaftor), the First Medicine to Treat the Underlying Cause of Cystic Fibrosis
Vertex Pharmaceuticals announces KALYDECO approved to treat people with CF who have a specific genetic mutation.

Body Clock Receptor Linked to Diabetes in New Genetic Study
Study found that people who carry rare genetic mutations in the receptor for melatonin have higher risk of type 2 diabetes.

Pinpoint Genomics Announces Publication of Clinical Study Results in Lung Cancer
The Pinpoint Dx Lung(TM) Assay is a molecular diagnostic assay that assesses the likelihood of death after lung cancer surgery.

OGT Releases New Whitepaper for Aiding Biomarker Discovery
The new document explores the need for biomarkers as indicators of disease, and discusses the vast potential of autoantibodies as markers of early disease development.

Scripps Research Scientists Create Novel RNA Repair Technology
Discovery could aid search for Huntington’s, Spinocerebellar Ataxia, and Kennedy Disease treatments.

Biobanking - Collaborating for Global R&D and Investment 19 May 2011 With unquestionable commercial growth opportunities, biobanks need to deliver quality samples to create value for biomarker discovery and personalised medicine. However who should implement quality control; should biobanks be self regulating or should an independent certified organisation develop a system of accreditation? SMi's inaugural Biobanking conference is the perfect opportunity to network with the industry's leading figures and contribute to the successful future of drug discovery. Join us at the Crowne Plaza - The City, London, on the 11th - 12th July to discuss the latest developments in the biobanking arena. Take part in this brilliant forum which aims to bridge the gap between the worlds' leading academia and the pharma industry. One of the focal points at this conference will be the impact of drug discovery on neurology disorders. Dr Rivka Ravid, Senior Scientist, Royal Dutch Academy of Sciences, Brain Bank Consultants, will use her wealth of knowledge to inform delegates of the pitfalls and practicalities in the daily practice of Brain Banks for biomedical research. Dr Sven Kili, Global Medical Director - Cell Therapy & Regenerative Medicine, Genzyme, provides a thorough insight regarding the application of regenerative medicine. Like most strands of medical research, the value and ultimate success of regenerative medicine in tissue engineering relies heavily on the ability to maintain quality standards in a sample collection. The forum will also look at the operational considerations within biobanking and the need for standardisation within the various networks. George Tokiwa, Associate Scientific Director at Merck will spearhead a panel-led debate regarding the most suitable system of accreditation with use of case studies to highlight best practice between biobanks. These are just a few of the reasons why you should attend SMi's Biobanking conference. For further information please visit the website: http://www.smi-online.co.uk/bio-banking-event63.asp Keep an eye on this blog, updates to follow!
Posted By: awilliamson@smi-online.co.uk	4 Comments

Welcome To Our Blog 17 May 2011 Firstly hello and welcome to the new Technology Networks Blog. The blog section on all Technology Networks communities allows you to share your latest research, product developments and experiences with researchers and scientific professionals in your chosen field. So why not share your views and experiences with our global subscribers? Happy Blogging!!
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