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  Events - March 2013

NGS for Drugs, Patients and Clinical Trials

21 Mar 2013 - 22 Mar 2013 - San Diego, CA, USA

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Next-Generation Sequencing (NGS) is poised to revolutionize the drug discovery paradigm by offering unprecedented interrogation of the human genome at high resolution and relatively low costs. While the widespread implementation of NGS is apparent, issues specific to drug development present new challenges for developers.  Join Cambridge Healthtech Institute for NGS for Drugs, Patients and Clinical Trials and explore the unparalleled advantages and arising challenges in using NGS technologies for translational research.                                                                                                                                                           

Discussions will cover:

  • NGS for Decision Making During Drug Development and Clinical Trials
  • Developing Informatics Infrastructure & Pipelines to Handle Complex NGS Data
  • Navigating Regulatory Hurdles of Informed Consent and Data Sharing
  • Harnessing NGS Technologies for Identification of Causal Variants and "Driver" Mechanisms in Disease

Featured presentations include:

Profiling and NGS in Cancer: Challenges and Applications to Targets, Models, and Resistance

Paul Rejto, Ph.D., Director, Computational Biology, Oncology Research Unit, Pfizer, Inc.

Devising Methods for Intuitively Handling Huge Data Sets to Simplify Biomarker Discovery

Dongliang Ge, Ph.D., Director, Bioinformatics, Gilead Sciences, Inc.

Further information
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Cocoa Compound Linked to Some Cardiovascular Biomarker Improvements
The study highlights the urgent need for large, long-term RCTs that improve understanding of how the short-term benefits of cocoa flavanol intake on cardiometabolic biomarkers may be translated into clinical outcomes.
New Pathway for COPD Biomarker Development
A study from Philip Morris International has highlighted multi-lipid profiling as a potential new pathway for COPD biomarker development.
Anti-Cancer Drug Uses Tumour mRNA to Identify Responders
Phase I study of novel anti-cancer drug uses tumour mRNA expression to identify patients who will respond to the drug.
Genetic Signature Linked to Cancer Prognosis Identified
The results of the analysis of 8,161 tissue samples could in the future help clinicians decide how best to treat a patient as well as aid the development of new targeted treatments.
NIH Commits $6.7 M to Advance DNA, RNA Sequencing Technology
"Can you believe they make DNA sequencers the size of staplers?" asked Meni Wanunu, Ph.D. "Ideas that were crazy twenty years ago are now happening!"
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LABVOLUTION 2017 will have an added highlight of a simultaneous conference, "3D-Printing in Science".
Curcumin Shows Promise as Cancer Treatment
When delivered at the correct circadian phase, curcumin demonstrates sustained toxicity in cancer cells and should be considered for use in patient care.
"Junk" DNA Critical for Heart Function
Loss of noncoding elements of genome, known as enhancers, results in abnormalities of heart functions.
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