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Featured Products
Featured Product - Phosphoramidites and Solid Supports for Oligonucleotide Synthesis
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Webcasts
Webcast - The Lipidyzer™ Platform: A Revolutionary Tool for Understanding the Role of Lipids in DiseaseThe Lipidyzer™ Platform: A Revolutionary Tool for Understanding the Role of Lipids in Disease
Join us to learn about the key challenges in lipid analysis and how the Lipidyzer platform can help you overcome them.
Webcast - Walk-Away Monitoring of Cytotoxicity, Viability and ApoptosisWalk-Away Monitoring of Cytotoxicity, Viability and Apoptosis
Join us to learn how to simplify and automate cell viability and cytotoxicity assessment for your cell analysis workflows.

Market Reports
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Companion Diagnostics and Personalized Medicine
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the companion diagnostics (CDx) and personalized medicine marketplace. Personalized medicine is a broad field with several stakeholders all of which must be aligned in order to capture the immense potential value in targeting therapeutics to the correct patient population—the field of stratified medicine.
MicroRNAs and Exosomes
Select Biosciences Ltd

In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights

Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Epigenetics Market Trends 2011
Select Biosciences Ltd

Epigenetics research efforts are growing around the world driven by the numerous documented associations of epigenetic modifications with diseases—especially various types of cancers.
Advances in the Use of Biomarkers in Biochip and Microarray Testing: Innovative Technologies, Growth Opportunities and the Future Market Outlook
Business Insights

The microarray market (estimated at $788m for 2008, including about $130m in protein arrays) is forecast to grow by 9% per annum to $1322m in 2013. Diagnostic microarrays, currently with just $39m (5% of the total), are expected to reach $187m (14%) by 2013. The leading diagnostic application at present is cancer.
The Future of Molecular Diagnostics: Innovative technologies driving market opportunities in personalized medicine
Business Insights

This report analyzes the current and potential world markets for molecular diagnostics, including advances in the field. This report generally forecasts future growth to 2015. The report breaks down market forecasts by type of test and by geography. It indicates which companies have key products in the market place. It also analyzes key drivers of this market.
Impact of Pharmacogenomics on Public Healthcare Policy: Educating patients, payors and healthcare providers
Business Insights

Impact of Pharmacogenomics on Public Healthcare Policy: Educating patients, payors and regulators is a report that examines how PGx implementations can help to improve efficiency and productivity within the industry, across the fields of pharma, biotech and diagnostics. The PGx strategies of major companies are profiled and recent alliances and licensing opportunities are highlighted.
Multiplexed Diagnostics 2010
Select Biosciences Ltd

The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights

There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
Scientific News
Contagious Cancers Are Spreading in Shellfish
Direct transmission of cancer among some marine animals may be more common than once thought, suggests a new study published in Nature by researchers at Columbia University Medical Center (CUMC).
Contagious Cancers Are Spreading in Shellfish
Direct transmission of cancer among some marine animals may be more common than once thought, suggests a new study published in Nature by researchers at Columbia University Medical Center (CUMC).
Fix for 3-Billion-Year-Old Genetic Error
Researchers at The University of Texas at Austin have developed a fix that allows RNA to accurately proofread for the first time.
“Amazing Protein Diversity” Discovered in Maize
The genome of the corn plant – or maize, as it’s called almost everywhere except the US – “is a lot more exciting” than scientists have previously believed. So says the lead scientist in a new effort to analyze and annotate the depth of the plant’s genetic resources.
Higher Frequency of Huntington's Disease Mutations Discovered
University of Aberdeen study shows that the gene change that causes Huntington's disease is much more common than previously thought.
Revealing the Genetic Causes of Bowel Cancer
A landmark study has given the most detailed picture yet of the genetics of bowel cancer — the UK's fourth most common cancer.
Tumor Cells Develop Predictable Characteristics
Scientists have discovered that cancer cells at the edge of a tumor that are close to the surrounding environment are predictably different from the cells within the interior of the tumor.
New Imaging Method Reveals Nanoscale Details about DNA
Enhancement to super-resolution microscopy shows orientation of individual molecules, providing a new window into DNA’s structure and dynamics.
Genetic Research Can Significantly Improve Drug Development
With drug development costs topping $1.2bn (£850 million) to get a single treatment to the point it can be sold and used in the clinic, could genetic analysis save hundreds of millions of dollars?
Diagnosing Systemic Infections Quickly, Reliably
Team develop rapid and specific diagnostic assay that could help physicians decide within an hour whether a patient has a systemic infection and should be hospitalized for aggressive intervention therapy.
Business News
Thermo Fisher, West China Hospital Announce Partnership
Partnership aims to develop a joint platform to research precision medicine.
Notable Labs, IntelliCyt Announce Collaboration
Collaboration aims to develop a phenotypic personalized medicine platform for cancer patients.
Waters Collaborates with Singapore’s Bioprocessing Technology Institute
Organizations partner to enhance the development of analytical methods and glycan libraries for cancer glycobiology, focusing on glycosphingolipids.
£18m Lab Opens to Discover the Clues to Individuals’ Illnesses
The Centre will identify biomarkers – the molecular clues that indicate the presence of a disease or condition.
Celgene Announces $50M in Cancer Collaborations
Pioneering public-private cancer initiative with unified leadership committed to changing the course of cancer care.
Strata Completes Series A Financing
The financing will fuel Strata's tumor sequencing operation and implementation of the Strata trial.
MRC Technology, AstraZeneca Collaborate
Companies launching an initiative to find new epigenetic drug targets in respiratory disease.
Protagen Announces CE Mark for its Proprietary Multilisa® BICD2 Test
BICD2 is the first proprietary biomarker discovered by Protagen employing the SeroTag® technology platform, and provides significant added value to standard diagnostics for Systemic Sclerosis (SSc).
BMS, MD Anderson Announce Immuno-Oncology Collaboration
Bristol-Myers Squibb and The University of Texas MD Anderson Cancer Center have announced a new clinical research collaboration to evaluate innovative strategies for the potential use of Bristol-Myers Squibb’s immuno-oncology (I-O) agents Opdivo (nivolumab) and Yervoy (ipilimumab) to treat early- and advanced-stage lung cancer patients.
Zero Childhood Cancer Program Receives $20M Funding
Australian Prime Minister announces major funding commitment for Zero Childhood Cancer.

Events
Extracellular Vesicles 2016
12 Jul 2016
Extracellular Vesicles 2016 ...
The Lipidyzer™ Platform: A Rev
19 Jul 2016
The Lipidyzer™ Platform: A Rev ...
EMC 2016 - The 16th European M
28 Aug 2016
EMC 2016 - The 16th European M ...
Event - Liquid Biopsies & Minimally-In
29 Sep 2016
Liquid Biopsies & Minimally-In ...

ePosters
Molecular Abnormalities in Schizophrenia: Neurotransmission, Oxidative Stress, and Apoptosis
1Section of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London SW7 2AZ, U.K. 2

A multi-platform approach was employed to analyse distinct brain regions implicated in schizophrenia.
Accurate Mass Spectral Database: Harnessing the Power of High Performance Mass Spectrometry at Long Last
LECO Corporation, Moscow State University

Standard mixtures comprising of alkanes, PAHs, semivolatiles, and pesticides were analyzed using a high resolution time-of-flight (HRTOF) mass spectrometer—Pegasus GC-HRT (LECO Corporation, Saint Joseph,MI)—at 10 spectra-per-second (m/z40–300) in high resolution mode (25,000 at FWHH). The resulting chromatographic peaks were automatically found, deconvoluted, and curated into an Accurate Mass Library (AML).
Automated Sample Preparation of Whole Blood for Therapeutic Drug Monitoring and Diagnostics by LC-MS using a Commercial Autosampler
1 University of Applied Sciences and Arts Northwestern Switzerland FHNW, Institute for Chemistry and Bioanalytics , Gründenstrasse 40, 4132 Muttenz; 2 CTC Analytics AG; Industriestrasse 20, CH-4222 Zw

In this poster the parameters necessary to automatically prepare whole blood samples for online LC-MS applications in the field of diagnostics and TDM have been investigated. A strategy and the most important parameters are shown for the optimization of a PAL RTC autosampler
for the preparation of whole blood samples.
Development and Application of Quantitative Immunoassays for Major Milk Allergens Bos d 5 (β-lactoglobulin) and Bos d 11 (β-casein)
1. Indoor Biotechnologies, Ltd., Cardiff, Wales, UK. 2. INRA, Gif-sur-Yvette, France

In this study, we sought to develop accurate, sensitive and reliable assays that would enable quantification of multiple milk allergens.

Diagnosing Coral disease with Metabolomic Markers
NYUAD

Application of untargeted metabolomics for the identification of disease markers in corals
Quantitative Cell-Based Bioassays for Individual and Combination Immune Checkpoint Immunotherapy Targets
Promega Corporation

Immune checkpoint receptors are promising new immunotherapy
targets for the treatment of a variety of diseases including cancer and
autoimmune-mediated disorders. We developed a suite of cell-based
bioluminescent reporter bioassays for individual and combination
immune checkpoint immunotherapy targets including: PD-1 (PD-L1 or PD-L2), CTLA-4, LAG-3, TIGIT, PD-1+TIGIT, GITR, 4-1BB, CD40, and OX40.

A Novel Set of Serum-Free, Xeno-Free Differentiation Media for Adipogenesis, Osteogenesis and Chondrogenesis of Human Mesenchymal Stem Cells from Various Tissue Sources
Biological Industries

An overview of a novel SF, XF differentiation system which enables achieving defined conditions for rapid generation of differentiated hMSCs towards tissue engineering and drug screening applications
A Synthetic CRISPR-Cas9 System for Homology-directed Repair
Dharmacon (part of GE Healthcare)

Synthetic, dual-RNA-encoded Cas9 is used for precise homology-directed repair (HDR) gene engineering. Both short and long (GFP) inserts are covered.
CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
Dharmacon (part of GE Healthcare)

CRISPR-Cas9 gene editing using synthetic crRNA:tracrRNA or sgRNA is highly efficient and easy to use. Synthetic crRNA:tracrRNA is uniquely suited to in vitro and in vivo applications, in particular, DNA-free approach with Cas9 mRNA. Chemical synthesis of guide RNAs allows accurate and rapid production of arrayed crRNA libraries for high-confidence, loss-of-function screens.
Deep Phenotyping - Harnessing Data Richness for Unsupervised High-Content Analysis
Institute of high performance Computing, Astar

Recognising the key challenges, we develop an end-to-end computational framework for HCA dubbed “Deep Phenotyping” that perform unsupervised analysis to leverage on the data richness for the discovery of unknown sub-phenotypes with minimal labeling cost.
Application Notes
SNP Genotyping of Field Corn Samples with LGC Genomics Chemistry on the Nexar® System
Douglas Scientific

A recent study demonstrated that the Nexar® System can be successfully used to produce repeatable and easily scored SNP genotyping results with crude preps from field corn using either KASP or probe-based SNP genotyping assays in miniaturized reaction volumes. This platform also provides significant cost savings in the form of reduced PCR reaction volumes.
Genotyping of Human Reference DNA Samples with Pharmacologically Important Single Nucleotide Polymorphisms using KASP™ Genotyping Chemistry on the Nexar® System
Douglas Scientific

Five pharmacologically important SNPs were analyzed with a miniaturized PCR-based SNP genotyping method using KASP™ genotyping reagents and the Douglas Scientific® Nexar®. The Nexar along with Array Tape® significantly reduces reaction volumes, hands-on effort and over-all cost of SNP genotyping, leading to a reliable and economical alternative to traditional PCR-based SNP genotyping techniques.
Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
Douglas Scientific

A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.
Evaluation of a New Accurate, Automated and Cost-effective Approach for the Analysis of Pharmacologically Important Copy Number Variation
Douglas Scientific

The IntelliQube® from Douglas Scientific® is designed to address the need for accurate and reliable results for studies such as CNV determination.
Directional qRNA-Seq: Combining the Power of Stranded RNA-Seq with the Quantitative Precision of Molecular Labels
Bioo Scientific

Bioo Scientific introduces a novel product for advanced RNA-Seq library preparation that features strand-specific RNA sequencing and correction of PCR amplification bias by molecular indexing: the NEXTflex™ Rapid Directional qRNA-Seq™ Kit.
Automating ELISAs on Tecan’s Freedom EVO® using Optimiser™ technology from Siloam Biosciences
Tecan Group Ltd.

One of the challenges in life sciences research today is to discover methods for running key assays more quickly, more reliably and using lower volumes of reagents and sample, but still with improved sensitivity. One area where this particularly holds true is for traditional enzyme-linked immunosorbent assays (ELISAs), whose application provides a useful measurement of antigens, including cytokines and a host of other biomarkers.
Molecular indexing for improved RNA-Seq analysis
Bioo Scientific

Most modern methods for nucleic acid analysis require the use of enzyme processing, such as DNA polymerase reactions, in the sample preparation or measurement steps. Although necessary, these enzymatic steps introduce errors in the form of incorrect sequence and misrepresented copy number. NEXTflex™ qRNA-Seq™ Kit from Bioo Scientific adds no additional steps to the work flow, costs no more than a conventional library preparation kit and increases the precision of downstream analysis.
Purification of Genomic DNA from Saliva Using Oragene® Discover Collection Kits and the Akonni TruTip® Extraction System on the Hamilton Microlab® STAR Liquid Handling Workstation
Hamilton

In the following studies, we have demonstrated the high precision of the automated TruTip extraction technology in processing genomic DNA from low-volume saliva samples and its advantage over competitors.
Rapid, High Throughput Extraction and Purification of Genomic DNA from Whole Blood Using the Akonni TruTip® Extraction System on the Hamilton Microlab® STAR Liquid Handling System
Hamilton

This application note demonstrates the high precision of the automated extraction system in processing genomic DNA from low volume whole blood samples and its advantage over competitors.
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Hamilton

The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.
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