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Genomic Assessment of Human Cumulus Cell Marker Genes

Published: Thursday, August 02, 2012
Last Updated: Thursday, August 02, 2012
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Study includes the investigation of the impact of technical and biological variability such as qPCR series and patients on the level of gene expression.

Background

Single embryo transfer (SET) is the most successful way to reduce the frequency of multiple pregnancies following in vitro fertilisation. However, selecting the embryo for SET with the highest chances of pregnancy remains a difficult challenge since morphological and kinetics criteria provide poor prediction of both developmental and implantation ability. Partly through the expression of specific genes, the oocyte-cumulus interaction helps the oocyte to acquire its developmental competence. Our aim was therefore to identify at the level of cumulus cells (CCs) genes related to oocyte developmental competence.

This study is published online in PLoS ONE and is free to access.


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