Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
Become a Member | Sign in
Home>News>This Article

Genome-wide DNA Methylation and Gene Expression Analyses of Monozygotic Twins Discordant for IQ Levels

Published: Wednesday, October 24, 2012
Last Updated: Wednesday, October 24, 2012
Bookmark and Share
Regarding that MZ twins are identical in genetic composition, the IQ difference could be associated with environmental factors, via epigenetic mechanisms regulations.

Human intelligence, as measured by intelligence quotient (IQ) tests, demonstrates one of the highest heritabilities among human quantitative traits. Nevertheless, studies to identify quantitative trait loci responsible for intelligence face challenges because of the small effect sizes of individual genes. Phenotypically discordant monozygotic (MZ) twins provide a feasible way to minimize the effects of irrelevant genetic and environmental factors, and should yield more interpretable results by finding epigenetic or gene expression differences between twins. Here we conducted array-based genome-wide DNA methylation and gene expression analyses using 17 pairs of healthy MZ twins discordant intelligently. ARHGAP18, related to Rho GTPase, was identified in pair-wise methylation status analysis and validated via direct bisulfite sequencing and quantitative RT-PCR. To perform expression profile analysis, gene set enrichment analysis (GSEA) between the groups of twins with higher IQ and their co-twins revealed up-regulated expression of several ribosome-related genes and DNA replication-related genes in the group with higher IQ. To focus more on individual pairs, we conducted pair-wise GSEA and leading edge analysis, which indicated up-regulated expression of several ion channel-related genes in twins with lower IQ. Our findings implied that these groups of genes may be related to IQ and should shed light on the mechanism underlying human intelligence.

This article is published online in PLoS One and is free to access.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

A Metabolomic Perspective on Coeliac Disease
Metabolomics has proved to be a useful complement for the characterization of several physiological and pathological conditions and offers promises as a clinical tool.
Monday, April 07, 2014
An Alternative Suite of Universal Primers for Genotyping in Multiplex PCR
The new set of universal primers for multiplex genotyping were proven to be efficient and reliable in varied species.
Thursday, March 27, 2014
Application of MALDI-TOF Mass Spectrometry in Clinical Virology
MS methods can be used currently for viral diagnosis but refinement of technology will be an important approach for the introduction of MALDI-TOF in routine viral diagnosis.
Monday, December 16, 2013
Identification of Plasma Lipid Biomarkers for Prostate Cancer by Lipidomics and Bioinformatics
This study explores a new approach to seeking biomarkers for prostate cancer and other diseases.
Monday, April 08, 2013
Genomic Assessment of Human Cumulus Cell Marker Genes
Study includes the investigation of the impact of technical and biological variability such as qPCR series and patients on the level of gene expression.
Thursday, August 02, 2012
Genotyping Performance Between Saliva and Blood-derived Genomic DNAs on the DMET Array
Study also evaluates possible ways to improve the saliva-derived DNA genotyping call rate.
Friday, June 15, 2012
Evaluation of Candidate Reference Genes for Gene Expression Normalization
Study performed in Brassica juncea using real time quantitative RT-PCR.
Monday, May 21, 2012
Reliable and Rapid Characterization of Functional FCN2 Gene Variants Reveals Diverse Geographical Patterns
In this study, scientists genotyped and characterized four FCN2 functional SNP variants in West Africans, South Americans, South East Asians from Vietnam and Caucasians from Germany using an available rapid, reliable and cost effective FRET-RTPCR methodology.
Monday, May 21, 2012
Study of Helicobacter pylori Genotype Status in Saliva, Dental Plaques, Stool and Gastric Biopsy Samples
This study aimed to compare H. pylori cagA and the vacA allelic status among strains isolated from saliva, dental plaque, gastric biopsies and stool samples in the same patient with dyspepsia manifestations in order to evaluate the mode of transmission of H. pylori infection.
Wednesday, May 16, 2012
Serious Bacterial Infection Biomarkers Uncovered using Transcriptomic Analysis
Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children.
Monday, May 14, 2012
Selection of Suitable Reference Genes for RT-qPCR Analyses in Cyanobacteria
In this work we have validated candidate reference genes for accurate normalization of RT-qPCR data in cyanobacteria. Several genes were selected and their transcription analyzed in three morphological distinct organisms.
Monday, April 23, 2012
DNA Methylation Analysis of Bone Marrow Cells at Diagnosis of Acute Lymphoblastic Leukemia and at Remission
The aim of this study was to identify genes that display aberrant DNA methylation independently of cytogenetic ALL subtype for further mechanistic studies of ALL.
Monday, April 16, 2012
Integrated Analyses of microRNAs Demonstrate Their Widespread Influence on Gene Expression in High-Grade Serous Ovarian Carcinoma
The Cancer Genome Atlas (TCGA) Network recently catalogued the molecular aberrations in 487 high-grade serous ovarian cancers. This study surveys the miRNAs, in the context of their predicted gene targets.
Monday, April 16, 2012
The Next Phase of Life-Sciences Spaceflight Research: Harnessing the Power of Functional Genomics
This article discusses potential applications of RNAi and GFP in spaceflight studies and the ramifications of these experiments for the future of space life-sciences research.
Monday, April 02, 2012
Keratinocyte Growth Factor Induces Gene Expression Signature Associated with Suppression of Malignant Phenotype of Cutaneous Squamous Carcinoma Cells
This study examined the effect of KGF on cutaneous SCC cells. The results show that although most SCC cell lines express KGFR, KGF does not stimulate their proliferation.
Thursday, March 22, 2012
Scientific News
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Measuring microRNAs in Blood to Speed Cancer Detection
A simple, ultrasensitive microRNA sensor holds promise for the design of new diagnostic strategies and, potentially, for the prognosis and treatment of pancreatic and other cancers.
Personalized Drug Screening for Multiple Myeloma Patients
A personalized method for testing the effectiveness of drugs that treat multiple myeloma may predict quickly and more accurately the best treatments for individual patients with the bone marrow cancer.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
New Way to Force Stem Cells to Become Bone Cells
Potential therapies based on this discovery could help people heal bone injuries or set hardware, such as replacement knees and hips.
Promise of Newborn Stem Cells to Revolutionize Clinical Practice
In this article Shweta Sharma, PhD, discusses the potential of an Umbilical Cord Blood bank as an untapped source of samples for research and clinical trials.
New Anti-Malarial Drug Screening Model
University of South Florida researchers demonstrate novel chemogenomic profiling to identify drug targets for the most lethal strain of malaria.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos