Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
Become a Member | Sign in
Home>News>This Article

Oscillation of Gene Activity May Underlie How Embryos Grow in Proportion

Published: Wednesday, January 09, 2013
Last Updated: Wednesday, January 09, 2013
Bookmark and Share
The size of pre-vertebrae in a mammalian embryo is controlled by a wave-like gene expression pattern along its back.

From a single-cell egg to a fully functional body: as embryos develop and grow, they must form organs that are in proportion to the overall size of the embryo. The exact mechanism underlying this fundamental characteristic, called scaling, is still unclear. However, a team of researchers from EMBL Heidelberg is now one step closer to understanding it. They have discovered that scaling of the future vertebrae in a mouse embryo is controlled by how the expression of some specific genes oscillates, in a coordinated way, between neighbouring cells. Published today in Nature, their findings highlight how important this oscillatory pattern, and its regulation, is to ensure that embryos grow up to become well-proportioned animals.

Neighbouring cells in the future vertebral column of an embryo coordinate to turn specific genes on and off in turn, thus generating a wave of gene expression similar to the ‘Slide to unlock’ animation on your smart phone. To study this process, and determine its impact on how the relative sizes of the future vertebrae are maintained, the researchers developed a new technique.

“Using this new assay, we were able to film this wave of gene expression in real time with high precision, and to identify whether this pattern could change according to the overall size,” explains Alexander Aulehla who coordinated the study at EMBL Heidelberg. “There is a clear link: when the embryo is smaller, the number of segments formed remains the same, but each segment is smaller and the expression waves are proportionally slower.”

The speed of the wave seems to be the essential characteristic to predict the size of the future vertebra: the faster the wave, the bigger the vertebra. Similar expression waves have been observed in several vertebrates and also in insect species, so this communication pattern amongst embryonic cells seems to be very wide-spread. However, scientists haven’t yet elucidated how the speed of the wave is controlled at a molecular level.

The technique developed in this study might be the key to helping the team understand this complex and fundamental mechanism. In order to make observation easier, the scientists grew only one layer of embryonic stem cells to which a specific marker was added, to follow the expression of the Notch genes. The combination of the monolayer and marking made real-time observation of gene expression possible. In the future this new technique might help researchers understand the details of how embryonic cells sync to grow.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Measuring microRNAs in Blood to Speed Cancer Detection
A simple, ultrasensitive microRNA sensor holds promise for the design of new diagnostic strategies and, potentially, for the prognosis and treatment of pancreatic and other cancers.
Personalized Drug Screening for Multiple Myeloma Patients
A personalized method for testing the effectiveness of drugs that treat multiple myeloma may predict quickly and more accurately the best treatments for individual patients with the bone marrow cancer.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
New Way to Force Stem Cells to Become Bone Cells
Potential therapies based on this discovery could help people heal bone injuries or set hardware, such as replacement knees and hips.
Promise of Newborn Stem Cells to Revolutionize Clinical Practice
In this article Shweta Sharma, PhD, discusses the potential of an Umbilical Cord Blood bank as an untapped source of samples for research and clinical trials.
New Anti-Malarial Drug Screening Model
University of South Florida researchers demonstrate novel chemogenomic profiling to identify drug targets for the most lethal strain of malaria.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos