Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Discovering the Secrets of Tumour Growth

Published: Monday, January 28, 2013
Last Updated: Monday, January 28, 2013
Bookmark and Share
Scientists have identified a compound that blocks the expression of a protein without which certain tumours cannot grow.

This compound has the potential as an anticancer agent according to the research published in the journal CHBIOL: Chemistry and Biology this week.

The BLM protein is also known to be important in maintaining stability in cells when they multiply, thus preventing cancer. However, certain types of tumour need BLM to grow. This is typical of osteosarcomas - aggressive malignant tumours often seen in bone cancer – and also soft tissue sarcomas.

Now for the first time scientists have been able to turn off the BLM function in cells using an inhibitor called ML216, which stops cells that express BLM from multiplying, leaving cells without BLM alone.

Tumour treatment one step closer

Professor Ian D. Hickson, who led the research says: “Sarcomas and especially osteosarcomas are notoriously difficult to treat. This compound has the potential to lead to a treatment that could stop such tumours growing.”

Professor Hickson’s team is now working on finding derivatives of the compound that will be more potent and suitable to use as a basis for a drug.

“Once we have the compound in the right form, the next step is to test it using mice as a model and then, all being well, to move on to a clinical trial. However, we are several years off having an actual treatment.” He says.

The Nordea Center for Healthy Ageing was founded at the University of Copenhagen in 2008 thanks to funding from the Nordea Foundation. The centre focuses on interdisciplinary research into how people can live healthy lives and enjoy a robust old age.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Grants Attract Top Researchers to Copenhagen
Two international leading researchers have each been awarded a Novo Nordisk Foundation Laureate Research Grant of DKK 40 million (€ 5.36 million).
Monday, January 28, 2013
Isolation of a new Gene Family Essential for Early Development
Researchers have identified a new gene family essential for embryonic development that may contribute to the understanding of the development of cancer.
Thursday, August 23, 2007
Scientific News
Breast Cancer Cells Found To Switch Molecular Characteristics
Spontaneous interconversion between HER2-positive and HER2-negative states could contribute to progression, treatment resistance in breast cancer.
Some Breast Cancer Patients With Low Genetic Risk Could Skip Chemotherapy
Genetic test can help predict survival and guide treatment options.
LncRNAs Maintain Immune Health
Long non-coding RNAs are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders.
Enzyme that Triggers Cell Demise in ALS Identified
Scientists from Harvard have identified a key instigator of nerve cell damage in people with amyotrophic lateral sclerosis (ALS).
Molecular Alarm Clock Wakes Resting Ovules
Study of fruit flies yields discovery of a molecular "alarm clock" that activates resting ovules.
Improved Immunity in Older Age
A study from Oxford and Basel universities may point the way to maintaining our immune systems as we get older.
Neurodvelopmental Disorder Cause Linked to SON Gene
A genetic link has been discovered for a previously unxplained neurodevelopmental disorder.
Russian TB Thrives Within Macrophages
MIPT researchers have identified features of mycobacterium tuberculosis strains that may explain their success.
Gene Linked to Hearing Loss Identified
Researchers have identifed a gene associated with age-related hearing loss.
World's Most In-Depth Study to Detect Alzheimer's Disease
A multisite team will see the most thorough and vigorous testing for Alzheimer's ever performed on volunteers.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!