Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Study Finds Potential to Match Tumors with Known Cancer Drugs

Published: Friday, February 08, 2013
Last Updated: Friday, February 08, 2013
Bookmark and Share
Mapping the landscape of kinases could aid in new world of personalized cancer treatment.

When it comes to gene sequencing and personalized medicine for cancer, spotting an aberrant kinase is a home run. The proteins are relatively easy to target with drugs and plenty of kinase inhibitors already exist.

Now in a new study, University of Michigan Comprehensive Cancer Center researchers assess the complete landscape of a cancer’s “kinome” expression and determine which kinases are acting up in a particular tumor. They go on to show that those particular kinases can be targeted with drugs – potentially combining multiple drugs to target multiple kinases.

“We have a small but effective inventory of ‘druggable’ mutations that we know play a role in cancer. As we are doing more sequencing, we’re coming to realize just how small that inventory is. On the one hand, it’s a limitation. On the other hand, there are numerous oncogenic kinases, and there are a lot of kinase inhibitors. Our goal is to determine how to match more of these therapies with the right patients,” says senior study author Chandan Kumar-Sinha, Ph.D., research assistant professor at the Michigan Center for Translational Pathology.

The researchers looked at RNA sequencing data from 482 samples of both cancerous and non-cancerous tissue and identified the most highly expressed kinases in individual breast cancer and pancreatic cancer samples. They found certain common themes.

“A lot of samples showed one or two kinases that showed an outstandingly high ‘outlier’ expression,” says Kumar-Sinha. It wasn’t that the researchers always found a mutation – just that one or more kinases were expressed at a far higher level than all other kinases.

“We don’t always know what’s causing it to be overexpressed. But since it’s there, we know that somehow the high expression of oncogenic kinases is advantageous to the cancer, and so we can therapeutically exploit that dependency,” Kumar-Sinha says.

Results of the study appear online in the journal Cancer Discovery.

In breast cancer, the researchers spotted outlier expression of ERBB2 kinase in HER2-positive tumors, which would be expected. HER2-positive tumors can be treated with Herceptin. But they also found another kinase, called FGFR4 – and they found that adding a drug that blocks FGFR4, in combination with Herceptin, improved the anti-cancer effect. This was done only in cells in the laboratory, but the FGFR4-inhibitor continued to be effective in cells even after they became resistant to Herceptin.

In the pancreatic cancer samples, the researchers found several different kinases that have drugs that work against them, including MET, AKT and PLK. Pancreatic cancer is one of the most deadly types of cancer, often diagnosed in its late stages when treatments are not very effective. The main driver of pancreatic cancer, a mutation in a gene called KRAS, has proven difficult to target with treatments.

In the lab, researchers blocked the outlier kinases and found it had an effect against the cancer cells. They then blocked KRAS – something that can be done in the lab but has not been achieved in patients with pancreatic cancer – and found an even larger effect.

“If in the future we could target KRAS in patients and also hit the outlier kinases, it could have a huge impact on treatment of pancreatic cancer,” Kumar-Sinha says.

These findings must still be tested in patients, but researchers are hopeful that targeting specific kinases expressed in an individual patient’s tumor could make a difference.

The U-M Comprehensive Cancer Center is currently using gene sequencing techniques to help match advanced cancer patients with potential clinical trial opportunities based on the make-up of their tumor.

“We hope kinases will represent another available avenue with whole genome sequencing. If we can identify rational multiple targets for treatment, it’s more effective. This gets us one of those targets,” Kumar-Sinha says.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Ancient Viruses Lurk in Our DNA
One whole endogenous retrovirus genome -- and bits of 17 others -- were spotted in a study of 2,500 human genomes.
Thursday, March 24, 2016
Silencing X Chromosomes
Work could lead to ways to counteract X-linked diseases in girls and women.
Tuesday, January 12, 2016
Precision Medicine for Penile Cancer
Defining the genomic landscape reveals similarities with other squamous cell cancers.
Thursday, December 17, 2015
Adrenals Run Amok
Each of your kidneys wears a little yellow cap that helps keep your blood pressure in check, and much more. But in some people, it starts running amok, pumping out a hormone that sends blood pressure sky-high.
Friday, August 14, 2015
A Roadblock to Personalized Cancer Care
Experts call for more support for tumor biomarker tests; fixing a vicious cycle will lead to tests that better predict treatment success.
Tuesday, August 06, 2013
Smallest and Fastest-Known RNA Switches Provide New Drug Targets
Researchers say these rare, fleeting structures are prime targets for the development of new antiviral and antibiotic drugs.
Monday, October 08, 2012
University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections
New study uncovers significant proportion of potential false negatives in widely used HPV DNA test which could lead to cervical cancer.
Tuesday, July 21, 2009
Confusing Risk Information may Lead to Poor Cancer Treatment Choices
Tools designed to help guide treatment decisions are too complex for most patients to understand, U-M study finds.
Wednesday, December 10, 2008
U-M Study: Herceptin Targets Breast Cancer Stem Cells
The gene, HER2, causes cancer stem cells to multiply and spread, explaining why HER2 has been linked to a more aggressive type of breast cancer.
Thursday, July 10, 2008
Cancer Drug Works by Overactivating Cancer Gene
Michigan researchers have discovered that a promising cancer drug is able to strike a blow against melanoma tumor cells by revving up the action of a cancer-promoting gene.
Friday, November 23, 2007
Researchers Use New Method to Discover Gene Rearrangements
Genes rearrangements in prostate cancer cells may play a role in the development and progression of the disease.
Tuesday, November 01, 2005
Scientific News
AACR 2016: Cancer Immunotherapy and Beyond
At this year's meeting there was a palpable buzz around subjects ranging from microbiomics to the tumor microenvironment and cancer vaccines, big data to in vitro and in vivo modeling and drug delivery (to name just a few).
New Autism Blood Biomarker Identified
Researchers at UT Southwestern Medical Center have identified a blood biomarker that may aid in earlier diagnosis of children with autism spectrum disorder, or ASD.
Shining A Light On Bladder Cancer
Researchers scrutinize patterns of mutations in bladder tumor genomes, gleaning insights into the roles of DNA repair and tobacco-related DNA damage.
Faster, Cheaper Way to Produce New Antibiotics
A novel way of synthesising a promising new antibiotic has been identified by scientists at the University of Bristol.
Monovar Drills Down Into Cancer Genome
Rice, MD Anderson develop program to ID mutations in single cancer cells.
Autism, Cancer Share a Remarkable Number of Risk Genes
Researchers with the UC Davis Comprehensive Cancer Center, MIND Institute identify more than 40 common genes.
Number Of Known Genetic Risk Factors For Endometrial Cancer Doubled
An international collaboration of researchers has identified five new gene regions that increase a woman’s risk of developing endometrial cancer, one of the most common cancers to affect women, taking the number of known gene regions associated with the disease to nine.
FNIH Launches Project to Evaluate Biomarkers in Cancer Patients
Company has announced that it has launched a new project to evaluate the effectiveness of liquid biopsies as biomarkers in colorectal cancer patients.
Genetic Risk Factors of Disparate Diseases Share Similar Biological Underpinnings
Penn Institute for Biomedical Informatics and colleagues identify "roadmap" of disease mechanisms to identify candidate drug targets.
Childhood Asthma Research Receives $2M
Research into the impact of a child’s upbringing and social and physical environments on the development of asthma will receive $2 million to tackle the condition that affects as many as one in three Canadians.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!