Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

DNA Editor Named Runner-up Breakthrough of 2012

Published: Wednesday, February 27, 2013
Last Updated: Wednesday, February 27, 2013
Bookmark and Share
A discovery that allows life scientists to precisely edit genomes for everything from crop and livestock improvement to human gene and cell therapy was named runner-up for Science magazine's 2012 Breakthrough of the Year.

The work by Adam Bogdanove, Cornell professor of plant pathology and plant-microbe biology, joined eight other runners-up to Breakthrough of the Year -- the discovery of the Higgs boson -- in the magazine's Dec. 21 issue.

Bogdanove's breakthrough, which came in 2009 while he worked as a plant pathologist at Iowa State University, allows researchers to target and cut DNA in a living cell. Bogdanove identified a DNA targeting mechanism in proteins called TAL effectors that are used by plant pathogenic bacteria to alter gene expression in their hosts.

In 2010 he and collaborators at the University of Minnesota showed that these proteins could be used to carry an enzyme that cuts DNA, called a nuclease, that target specific DNA sequences in an organism's genome. The combination of TAL effector and nuclease is called a TALEN.

"The ability to cut DNA in living cells with TALENs allows researchers to modify DNA with higher efficiency than was previously possible," Bogdanove said. While another technology called zinc finger nucleases can also target specific genes, those nucleases are hard to make, and one company owns most of the patents. TALENs can be easily and cheaply constructed and are widely available.

TALENs give researchers the power not only to target and knock out specific gene sequences, but also to replace them with new DNA. The technology opens the door for medical applications such as gene therapy.

Depending on the nature of, say, a genetic defect, researchers may soon be able to extract a patient's cells, place them in a petri dish, remove the genetic mutation, replace that sequence with healthy code, and reintroduce the patient's own cells, now fixed, Bogdanove said.

Similarly, plant breeders may use TALENs to sidestep traditional breeding of crops by inserting new, site-specific genetic information, he added.

Bogdanove is working to further understand the basic biology of plant bacteria interactions with TAL effectors. "In that context, we expect to learn fundamental things of how these proteins interact with DNA that further inform technology development," he said.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

A ‘STAR’ is Born: Engineers Devise Genetic 'On' Switch
A new “on” switch to control gene expression has been developed by Cornell scientists.
Tuesday, February 03, 2015
Physicists Tease out Twisted Torques of DNA
Like an impossibly twisted telephone cord, DNA, the molecule that encodes genetic information, also often finds itself twisted into coils.
Monday, July 01, 2013
Gene Thought to be Linked to Alzheimer's is Marker for Only Mild Impairment
Defying the widely held belief that a specific gene is the biggest risk factor for Alzheimer's disease, report says that people with that gene are more likely to develop mild cognitive impairment -- but not Alzheimer's.
Monday, February 18, 2013
Scientific News
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Marijuana Genome Unraveled
A study by Canadian researchers is providing a clearer picture of the evolutionary history and genetic organization of cannabis, a step that could have agricultural, medical and legal implications for this valuable crop.
Growing Hepatitis C in the Lab
Recent discovery allows study of naturally occurring forms of hepatitis C virus (HCV) in the lab.
Signature of Microbiomes Linked to Schizophrenia
Studying microbiomes in throat may help identify causes and treatments of brain disorder.
Study Identifies the Off Switch for Biofilm Formation
New discovery could help prevent the formation of infectious bacterial films on hospital equipment.
Genetic Overlapping in Multiple Autoimmune Diseases May Suggest Common Therapies
CHOP genomics expert leads analysis of genetic architecture, with eye on repurposing existing drugs.
Fat in the Family?
Study could lead to therapeutics that boost metabolism.
Combo Tool
Joining molecular components expands ability to manipulate genes in specific cell types.
Team Identifies Structure of Tumor-Suppressing Protein
An international group of researchers led by Carnegie Mellon University physicists Mathias Lösche and Frank Heinrich have established the structure of an important tumor suppressing protein, PTEN.
Genes Associated With Improved Survival for Pancreatic Cancer Patients
Use of non-invasive liquid biopsies could predict in which patients the cancer could recur following surgery.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!