Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Lack of Sleep Alters Human Gene Activity

Published: Thursday, February 28, 2013
Last Updated: Thursday, February 28, 2013
Bookmark and Share
New research from the University of Surrey has found that as little as one week of inadequate sleep is enough to alter the activity of hundreds of human genes.

The BBSRC-funded research monitored the activity of all genes of the human genome and found that inadequate sleep (less than six hours a night) affects the activity of over 700 of our genes. These included genes which are linked to controlling inflammation, immunity, and the response to stress.

Furthermore, the research shows that inadequate sleep reduced the number of genes that normally peak and wane in expression throughout the 24-hour day from 1,855 to 1,481. The authors found that the number of genes affected by sleep deprivation was seven times higher after a week of insufficient sleep.

Sleep deficiency leads to a host of significant health conditions including obesity, heart disease, and cognitive impairment, but until now scientists were unclear how gene expression patterns were altered by insufficient sleep. These 'gene expression' patterns provide important clues on the potential molecular mechanisms linking sleep and overall health.

Derk-Jan Dijk, Director of the Sleep Research Centre at the University of Surrey, which receives funding from BBSRC, said: "This research has helped us to understand the effects of insufficient sleep on gene expression. Now that we have identified these effects we can use this information to further investigate the links between gene expression and overall health."

The research was conducted by an interdisciplinary team of researchers consisting of physiologists, sleep and circadian rhythm experts and experts in functional genomics and bioinformatics.

Colin Smith, Professor of functional genomics at the University of Surrey says: "The current interest in sleep and circadian rhythms as determinants of health and disease is a vital area of research. By combining our expertise in sleep and 'genomics' (the study of the full complement of our genes), we are starting to make breakthroughs that will have an impact on our understanding and treatment of poor health arising from insufficient sleep."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Chromosome Map Points the Way Through Campylobacter’s Genetic Controls
The Institute of Food Research has produced a new map of the Campylobacter genome, showing the points where all of this pathogenic bacteria's genes are turned on.
Wednesday, November 13, 2013
Moving Genes have Scientists Seeing Spots
An international team of scientists has perfected a way of watching genes move within a living plant cell.
Wednesday, September 11, 2013
Breaking up the Superbugs’ Party
The fight against antibiotic-resistant superbugs has taken a step forward thanks to a new discovery by scientists.
Friday, August 16, 2013
Researchers Pair Experiments with Computer Models to Peer into Cells
BBSRC-funded researchers have developed a new strategy that can give scientists a better insight into how complex molecular machineries function in living cells.
Wednesday, March 20, 2013
Collisions of Protein Machines Cause DNA Replication Derailment
Scientists have published results that will forever change the way researchers view the interplay between gene expression, DNA replication and the prevention of DNA damage.
Monday, February 28, 2011
Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Cancer Gene-Drug Combinations Ripe for Precision Medicine
The study aims to expand the number of cancer gene mutations that can be paired with a precision therapy.
New Centre Offers Ultra-Speed Protein Analysis
UW-Madison researchers to establish development centre for next-gen protein measurement technologies.
Disrupting Tumour-Promotion in Humans
Researchers have modified an existing protein to represses a specific cancer-promoting ‘message’ within cells.
Drug - Gene 'One-Two' Punch Against Cancer
Researchers identify gene-drug combinations that, together, target and kill cancer cells while not targeting healthy cells.
Drug Candidates Reduce Abnormal Protein Production
New drug candidates improve cell ability to catch miss-folded proteins that could cause deadly diseases.
Liquid Biopsies Treating Ovarian Cancer
Researchers have discovered a promising monitor and treat recurrence of ovarian cancer. Detecting cancer long before tumours reappear.
Diagnostic Thread - Weaving the Future?
Researchers have created diagnostic threads that could pave the way for next-gen implantable and wearable diagnostics.
Unravelling the Roots of Insect’s Waterproof Coating
Researchers have identified the genes that control cuticular lipid production in Drosophila, by performing an RNAi screen and using Direct Analysis in Real Time and GC-MS.
RNA Suppresses Inflammation
Researchers identify a long noncoding RNA that regulates innate immunity.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!