Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Identified a Key Protein in Maintaining the Identity of B Lymphocytes

Published: Monday, June 10, 2013
Last Updated: Monday, June 10, 2013
Bookmark and Share
This finding could be useful for the study of blood diseases such as lymphoma and leukemia.

Researchers of the Epigenetics and Cancer Biology Program at IDIBELL, led by researcher Maribel Parra, have identified a transcriptional repressor, histone deacetylase HDAC7, involved in the identity of B cells, the cells responsible to create antibodies in our immune system.

The results of the study, published in PLoS Genetics, show that HDAC7 is expressed specifically in B lymphocytes and do not in cells of other lineages such as macrophages.

Hematopoietic System

The blood stem cells go through a very complex system of differentiation to form the different blood cells. In the hematopoietic system, there are two main lines: the lymphoid, which results in T cells, B cells and NK cells, among others, and myeloid form erythrocytes (red blood cell) or macrophages among others.

As explained Maribel Parra, to take all the steps of differentiation, there must be changes in cell gene program. There are transcription factors that activate genes in each cell line but it also exist transcriptional repressors that impair the expression of "inappropriate" genes, characteristic of another lineage.

The lab of Maribel Parra studies the role of a family of transcriptional repressor proteins that are in the differentiation of cells of the hematopoietic system. The histone deacetylases (HDAC).
Repression of "inappropriate" genes.

In this work, researchers have shown that the role of HDAC7 protein is to suppress "inappropriate" gens characteristic of other lineages such as macrophages, in B lymphocytes.

Researchers rescheduled B lymphocyte precursor cells into macrophages (myeloid lineage), and found that the expression of HDAC7 decreased dramatically while returning to express this protein inducted blocking of key genes to macrophage biology.

Parra explained that "through this mechanism of transcriptional repression, Cell B ensures that genes characteristics of other cell types are not expressed and maintains its lymphoid identity." He also notes that "given its importance in the biology of B cells, HDAC7 function might be altered in haematological diseases such as leukaemia and lymphomas.  Our research is now going on that direction".


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,600+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Keeping Growth in Check
Ribosomal proteins RPL5 and RPL11 play an essential role in normal cell proliferation.
Friday, December 13, 2013
Discovered a Mechanism that Induces Migration of Tumor Cells in Liver Cancer
Coordinated overactivation of TGFb and CXCR4 signaling pathways confer migratory properties to the hepatocellular carcinoma cells.
Wednesday, November 06, 2013
Ángel Carracedo: ''Only 50% of First-Line Drugs are Effective''
The Professor of Legal Medicine and director of the Genomic Medicine lab at the University of Santiago de Compostela, talked of the future challenges of the field of pharmacogenetics in the clinic.
Wednesday, March 20, 2013
Scientific News
Higher Frequency of Huntington's Disease Mutations Discovered
University of Aberdeen study shows that the gene change that causes Huntington's disease is much more common than previously thought.
Revealing the Genetic Causes of Bowel Cancer
A landmark study has given the most detailed picture yet of the genetics of bowel cancer — the UK's fourth most common cancer.
Tumor Cells Develop Predictable Characteristics
Scientists have discovered that cancer cells at the edge of a tumor that are close to the surrounding environment are predictably different from the cells within the interior of the tumor.
New Imaging Method Reveals Nanoscale Details about DNA
Enhancement to super-resolution microscopy shows orientation of individual molecules, providing a new window into DNA’s structure and dynamics.
Genetic Research Can Significantly Improve Drug Development
With drug development costs topping $1.2bn (£850 million) to get a single treatment to the point it can be sold and used in the clinic, could genetic analysis save hundreds of millions of dollars?
Diagnosing Systemic Infections Quickly, Reliably
Team develop rapid and specific diagnostic assay that could help physicians decide within an hour whether a patient has a systemic infection and should be hospitalized for aggressive intervention therapy.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Scoliosis Linked to Disruptions in Spinal Fluid Flow
A new study in zebrafish suggests that irregular fluid flow through the spinal column brought on by gene mutations is linked to a type of scoliosis that can affect humans during adolescence.
A New Tool Brings Personalized Medicine Closer
Scientists from EPFL and ETHZ have developed a powerful tool for exploring and determining the inherent biological differences between individuals, which overcomes a major hurdle for personalized medicine.
Blood Test That Detects Early Alzheimer’s Disease
A research team, led by Dr. Robert Nagele from Rowan University School of Osteopathic Medicine and Durin Technologies, Inc., has announced the development of a blood test that leverages the body’s immune response system to detect an early stage of Alzheimer’s disease – referred to as the mild cognitive impairment (MCI) stage – with unparalleled accuracy.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,600+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!