Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Sequentially Expressed Genes in Neural Progenitors Create Neural Diversity

Published: Monday, June 24, 2013
Last Updated: Monday, June 24, 2013
Bookmark and Share
Scientists found that a series of genes sequentially expressed in brain stem cells control the generation of neural diversity in visual system of fruit flies.

In order for the brain to properly develop and function, a vast array of different types of neurons and glia must be generated from a small number of progenitor cells. By better understanding the details of this process, scientists can develop ways to recognize and remedy a range of neural afflictions such as microcephaly or neurodegeneration.

The research, conducted in the laboratory of NYU Biology Professor Claude Desplan, examined this process by studying the neurons in the visual centers of the fruit fly Drosophila. Drosophila is a powerful model for studying neural diversity because of its relative simplicity, although the studied brain structure, termed the medulla, contains approximately 40,000 neurons, belonging to more than 70 cell types.

Specifically, they examined the genes expressed in neuroblasts—dividing neural stem cells that generate neurons—in the medulla and how and when they are expressed. Their findings revealed that five genes encoding five different transcription factors—proteins that bind to specific DNA sequences—are expressed in a specified order in each of the medulla neuroblasts as they age. The five genes form a temporal cascade: one gene can activate the next gene and repress the previous gene, thus ensuring the progression of the temporal sequence.

It is this process, the researchers found, that controls the sequential generation of different neural types in the Drosophila medulla. These results, together with other studies in the field, suggest that a similar mechanism is utilized to generate neural diversity in the brains of humans and other mammals.

The study’s lead authors were Xin Li and Ted Erclik, post-doctoral fellows in the Desplan lab.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Minor Flu Strains Pack a Bigger Punch
Minor variants of flu strains, which are not typically targeted in vaccines, carry a bigger viral punch than previously realized, a team of scientists has found.
Tuesday, January 05, 2016
Researchers Find “Decoder Ring” Powers in microRNA
MicroRNA can serve as a "decoder ring" for understanding complex biological processes, a team of New York Univ. chemists has found.
Wednesday, May 27, 2015
Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
New Centre Offers Ultra-Speed Protein Analysis
UW-Madison researchers to establish development centre for next-gen protein measurement technologies.
Disrupting Tumour-Promotion in Humans
Researchers have modified an existing protein to represses a specific cancer-promoting ‘message’ within cells.
Drug - Gene 'One-Two' Punch Against Cancer
Researchers identify gene-drug combinations that, together, target and kill cancer cells while not targeting healthy cells.
Drug Candidates Reduce Abnormal Protein Production
New drug candidates improve cell ability to catch miss-folded proteins that could cause deadly diseases.
Liquid Biopsies Treating Ovarian Cancer
Researchers have discovered a promising monitor and treat recurrence of ovarian cancer. Detecting cancer long before tumours reappear.
Diagnostic Thread - Weaving the Future?
Researchers have created diagnostic threads that could pave the way for next-gen implantable and wearable diagnostics.
Unravelling the Roots of Insect’s Waterproof Coating
Researchers have identified the genes that control cuticular lipid production in Drosophila, by performing an RNAi screen and using Direct Analysis in Real Time and GC-MS.
RNA Suppresses Inflammation
Researchers identify a long noncoding RNA that regulates innate immunity.
Competition to Decipher RNA-Cancer Link
DREAM challenge aims to find the best algorithms for detecting abnormal RNA molecules in cancer cells.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!