Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
Become a Member | Sign in
Home>News>This Article

Alvetex 3D Cell Culture Scaffolds Chosen by Investigators at Massachusetts General Hospital

Published: Wednesday, July 31, 2013
Last Updated: Wednesday, July 31, 2013
Bookmark and Share
Scaffolds chosen for study of bone loss during space flight.

Reinnervate Ltd announced that its Alvetex®Scaffold system has been chosen by a group at Massachusetts General Hospital for the first ever 3D osteocytic cell culture experiments in microgravity.

Assistant Prof. of Medicine Paola Divieti Pajevic‟s group has been successfully using Alvetex®Scaffold to culture murine osteocytes in 3D to better mimic in-vivo growth conditions. Their long term aim is to understand the mechanisms of bone loss during unloading as occurs during prolonged bed rest, microgravity, or in diseases such as osteoporosis. The group has received funding from NIH and NASA to perform an experiment on the International Space Station in late 2014. This will expand their ongoing studies into the effects of bone loss during space flight. The group will culture osteocytes in bioreactors that will automate the process of feeding the cells during the ISS mission. This automatic system was specially designed by their implementation partners, CALM Technologies Inc.

„We are absolutely delighted that Alvetex Scaffold has been chosen for such an important and high profile project‟ said Prof. Stefan Przyborski, CSO and founder of Reinnervate. „3D cell culture is increasingly proving its worth in a wide variety of academic research areas. The ability to re-create more natural cellular structure, organisation and function in vitro is critical to advancing our understanding of basic cellular biology‟ he added.

Richard Rowling, commercial Director at Reinnervate added, „Dr. Divieti Pajevic‟s group looked at many different systems for 3D cell culture, but ultimately needed a simple product that is compatible with histology, to visualise cell structure and reliable recovery of total RNA to study gene expression profiles. Alvetex Scaffold was one of the few commercially available products that met all these criteria. We are really pleased that Alvetex®Scaffold is being used in such a fascinating project‟.

Dr. Divieti-Pajevic‟s group will continue to run experiments with Alvetex®Scaffold at her laboratory in the Endocrine Unit, Massachusetts General Hospital in the run up to the 2014 NASA mission. These experiments act as a control for normal gravitational conditions but also use the NASA developed rotating systems that aim to mimic micro-gravity. However, the go-ahead to run these studies on the ISS now offers the only real way to test their hypotheses.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
Cell's Waste Disposal System Regulates Body Clock Proteins
New way to identify interacting proteins could identify potential drug targets.
Compound Doubles Up On Cancer Detection
Researchers have found that tagging a pair of markers found almost exclusively on a common brain cancer yields a cancer signal that is both more obvious and more specific to cancer.
Lung Repair and Regeneration Gene Discovered
New role for hedgehog gene offers better understanding of lung disease.
Mixed Up Cell Transportation Key Piece of ALS and Dementia Puzzle
Researchers from the University of Toronto are one step closer to solving this incredibly complex puzzle, offering hope for treatment.
Five New Genetic Variants Linked to Brain Cancer Identified
The biggest ever study of DNA from people with glioma – the most common form of brain cancer – has discovered five new genetic variants associated with the disease.
Predictive Model for Breast Cancer Progression
Biomedical engineers have demonstrated a proof-of-principle technique that could give women and their oncologists more personalized information to help them choose options for treating breast cancer.
New Hope for Personalized Treatment of Eczema
Pharmaceutical researchers at Oregon State University have developed a new approach to treat eczema and other inflammatory skin disorders that would use individual tests and advanced science to create personalized treatments based on each person's lipid deficiencies.
Gene Expression: A Snapshot of Stem Cell Development
New genes found that regulate development of stem cells.
Are Changes to Current Colorectal Cancer Screening Guidelines Required?
Editorial suggests more research is needed to pinpoint age to end aggressive screening.
Assessing Cancer Patient Survival and Drug Sensitivity
RNA editing events another way to investigate biomarkers and therapy targets.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos