Corporate Banner
Satellite Banner
Genotyping & Gene Expression
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

BioRealm Receives $1 Million NIDA Award

Published: Friday, August 02, 2013
Last Updated: Friday, August 02, 2013
Bookmark and Share
Contract awarded to launch the Smokescreen® Genotyping Array for research on tobacco dependence and treatment approaches.

BioRealm, LLC announced it was awarded a $1 million Small Business Innovative Research (SBIR) Phase II contract from the National Institute on Drug Abuse (NIDA) to develop and launch the Smokescreen® genotyping array for research on tobacco dependence and treatment approaches. The array uses Affymetrix’ Axiom® genotyping technology to screen over 600,000 genetic variants to support research related to nicotine addiction, smoking cessation therapies, and consequences of tobacco use.

Smoking continues to be a leading preventable cause of disease, disability and death in the United States and worldwide. According to a recent report from the Centers for Disease Control and Prevention, smoking was estimated to be responsible for $96 billion in healthcare costs and an additional $97 billion in lost productivity in the United States annually. Due to the highly addictive properties of nicotine, people attempting to quit smoking often fail. Genetics is known to play a role in how strongly tobacco users become addicted and how they respond to different cessation therapies.

The Smokescreen product will be a targeted genotyping and software solution for scientists studying the genetics of nicotine addiction and smoking behavior, including those conducting clinical trials of smoking cessation therapies. The array will have excellent coverage of genomic regions associated with addiction, as well as biological pathways related to the metabolism of nicotine and the brain’s reward system. “Large-scale, disease-specific genotyping arrays have had a lot of success following up on prior research and discovering new risk loci”, stated Christopher Edlund, Bioinformatics Principal at BioRealm. "Tobacco addiction scientists will now have a unified genotyping array designed specifically for their research domain."

According to BioRealm, customers of Smokescreen will access their study data via a secure software application, built using the team’s statistical computing and genetics expertise. The software will feature automated quality control, data analysis pipelines, and the ability for researchers from different institutions to combine their data for powerful analyses.

During the two-year project, BioRealm will collaborate with top addiction researchers to develop a roadmap for future clinical products. "An important part of this project will be building a framework for biomarker development, which may classify smokers and suggest smoking cessation therapies based on individual characteristics, including genetics," said Dr. James Baurley, Co-founder of BioRealm. "Our team will be developing state-of-the-art statistical methods that combine all available data to build predictive models. This includes biological information, existing study data, and Smokescreen data as it becomes available."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Drug - Gene 'One-Two' Punch Against Cancer
Researchers identify gene-drug combinations that, together, target and kill cancer cells while not targeting healthy cells.
Drug Candidates Reduce Abnormal Protein Production
New drug candidates improve cell ability to catch miss-folded proteins that could cause deadly diseases.
Diagnostic Thread - Weaving the Future?
Researchers have created diagnostic threads that could pave the way for next-gen implantable and wearable diagnostics.
Unravelling the Roots of Insect’s Waterproof Coating
Researchers have identified the genes that control cuticular lipid production in Drosophila, by performing an RNAi screen and using Direct Analysis in Real Time and GC-MS.
RNA Suppresses Inflammation
Researchers identify a long noncoding RNA that regulates innate immunity.
Competition to Decipher RNA-Cancer Link
DREAM challenge aims to find the best algorithms for detecting abnormal RNA molecules in cancer cells.
Red Hair Gene Increases Cancer Mutations
Red hair gene variant drives up skin cancer mutations equivalent to that expected from 21 years of sun exposure.
Type 2 Diabetes Genetics Revealed
The largest study of its kind into type 2 diabetes has produced the most detailed picture to date of the genetics underlying the condition.
Blood Cancer Could be Prevented Before it Develops
New research suggests myeloma could be prevented before it develops out of symptomless condition in bone marrow.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!